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Current Oncology
Volume 18
Issue 3
10.3747/co.v18i3.761
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

Radiotherapy for Steroid-Resistant Laryngeal Rosai–Dorfman Disease

by
D. Toguri
1,
A.V. Louie
2,
K. Rizkalla
3,
J. Franklin
4,
G. Rodrigues
2 and
Varagur Venkatesan
2,*
1
Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada
2
Department of Radiation Oncology, London Regional Cancer Program, 790 Commissioners Road East, London, ON N6A 4L6, Canada
3
Department of Pathology, London Health Sciences Centre, London, ON, Canada
4
Department of Otolaryngology—Head and Neck Surgery, London Health Sciences Centre, London, ON, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2011, 18(3), 158-162; https://doi.org/10.3747/co.v18i3.761
Submission received: 6 May 2011 / Revised: 14 May 2011 / Accepted: 24 May 2011 / Published: 1 June 2011

Abstract

Rosai–Dorfman disease is a rare lymphoproliferative disorder that can have nodal and extranodal manifestations. In the absence of established guidelines for the management of this condition, various therapeutic modalities are used, including radiotherapy. Radiation dosages and fractionation schedules have not been reported in all instances. We present a case in which glottic and subglottic Rosai–Dorfman lesions causing airway obstruction in a frail steroid-refractory patient were put into complete remission using radiotherapy. The lesions responded transiently to a course of prednisone, but responded completely to external-beam radiation, with minimal side effects to the patient.
Keywords: Rosai–Dorfman disease; histiocytosis with massive lymphadenopathy; radiotherapy Rosai–Dorfman disease; histiocytosis with massive lymphadenopathy; radiotherapy

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MDPI and ACS Style

Toguri, D.; Louie, A.V.; Rizkalla, K.; Franklin, J.; Rodrigues, G.; Venkatesan, V. Radiotherapy for Steroid-Resistant Laryngeal Rosai–Dorfman Disease. Curr. Oncol. 2011, 18, 158-162. https://doi.org/10.3747/co.v18i3.761

AMA Style

Toguri D, Louie AV, Rizkalla K, Franklin J, Rodrigues G, Venkatesan V. Radiotherapy for Steroid-Resistant Laryngeal Rosai–Dorfman Disease. Current Oncology. 2011; 18(3):158-162. https://doi.org/10.3747/co.v18i3.761

Chicago/Turabian Style

Toguri, D., A.V. Louie, K. Rizkalla, J. Franklin, G. Rodrigues, and Varagur Venkatesan. 2011. "Radiotherapy for Steroid-Resistant Laryngeal Rosai–Dorfman Disease" Current Oncology 18, no. 3: 158-162. https://doi.org/10.3747/co.v18i3.761

APA Style

Toguri, D., Louie, A. V., Rizkalla, K., Franklin, J., Rodrigues, G., & Venkatesan, V. (2011). Radiotherapy for Steroid-Resistant Laryngeal Rosai–Dorfman Disease. Current Oncology, 18(3), 158-162. https://doi.org/10.3747/co.v18i3.761

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