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Open AccessArticle

Spirulina Platensis Supplementation Coupled to Strength Exercise Improves Redox Balance and Reduces Intestinal Contractile Reactivity in Rat Ileum

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Programa de Pós-graduação em Ciências (Fisiologia Humana), Instituto de Ciências Biológicas, Universidade de São Paulo, Sao Paulo/SP 05508900, Brazil
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Escola de Educação Física, Universidade de Pernambuco, Recife/PE 50740-465, Brazil
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Programa de Pós-graduação em Produtos Naturais e Sintéticos Bioativos, Centro de Ciências da Saúde, Universidade Federal da Paraíba, Joao Pessoa/PB, 58051900, Brazil
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Departamento de Educação Física, Centro de Ciências da Saúde, Universidade Federal da Paraíba, Joao Pessoa/PB 58051900, Brazil
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Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal da Paraíba, Joao Pessoa/PB 58051900, Brazil
*
Author to whom correspondence should be addressed.
Mar. Drugs 2020, 18(2), 89; https://doi.org/10.3390/md18020089
Received: 11 November 2019 / Revised: 20 December 2019 / Accepted: 27 December 2019 / Published: 29 January 2020
(This article belongs to the Special Issue Marine Natural Product and Oxidative Stress)
The blue alga Spirulina platensis has presented several pharmacological activities, highlighting its actions as an anti-inflammatory and antioxidant. In addition, there are few studies with the influence of strength training on physiological parameters, as intestinal contractility and oxidative cell damage. We evaluated the influence of S. platensis supplementation, strength training, and its association on contractile reactivity of rat ileum, as well as the balance of oxidative stress/antioxidant defenses. Methods: Male Wistar rats were divided into; sedentary (S); S + supplemented with algae at 50 (S50), 150 (S150), and 500 mg/kg (S500); trained (T); and T + supplemented (T50, T150, and T500). Contractile reactivity was analyzed by kymographs; oxidative stress on ileum by the malondialdehyde (MDA) formation; and the antioxidant capacity by 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. S. platensis supplementation reduced the reactivity of rat ileum to carbachol (CCh) and KCl, while training reduced only the CCh efficacy. In addition, association potentiated the reduction on contractile reactivity. Supplementation reduced the oxidative stress and increased oxidation inhibition; training alone did not alter this parameter, however association potentiated this beneficial effect. Therefore, this study demonstrated that both supplementation and its association with strength training promote beneficial effects regarding intestinal contractile reactivity and oxidative stress, providing new insights for intestinal disorders management. View Full-Text
Keywords: blue algae; Spirulina platensis; contractile reactivity; oxidative stress; ileum blue algae; Spirulina platensis; contractile reactivity; oxidative stress; ileum
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Araujo, L.C.C.; Brito, A.F.; Souza, I.L.L.; Ferreira, P.B.; Vasconcelos, L.H.C.; Silva, A.S.; Silva, B.A. Spirulina Platensis Supplementation Coupled to Strength Exercise Improves Redox Balance and Reduces Intestinal Contractile Reactivity in Rat Ileum. Mar. Drugs 2020, 18, 89.

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