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Medicina, Volume 61, Issue 2

2025 February - 197 articles

Cover Story: Nicotinamide is a derivate of vitamin B3 and is the precursor of NAD, a key coenzyme involved in several cellular reactions. NAM is often consumed daily and is endogenously produced by tryptophan. Additionally, NAM supplementation (500 mg–1 g/die) can efficiently protect cells from oxidative stress, DNA damages, inflammation and aging. Indeed, NAM inhibits two energy-demanding enzymes—PARP1 and SIRT1—leading to NAD restoration, which is fundamental for the DNA damage repair system. Moreover, NAM can reduce the release of proinflammatory cytokines and reactive oxygen species (ROS), enhancing the repair of DNA and the recovery of the cell cycle. View this paper
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Articles (197)

  • Article
  • Open Access
1 Citations
2,906 Views
12 Pages

Pulmonary Artery Pulsatility Index in Acute and Chronic Pulmonary Embolism

  • Mads Dam Lyhne,
  • Eugene Yuriditsky,
  • Vasileios Zochios,
  • Simone Juel Dragsbaek and ,
  • Jacob Valentin Hansen,
  • Mads Jønsson Andersen,
  • Søren Mellemkjær,
  • Christopher Kabrhel and
  • Asger Andersen
  • + 4 authors+ 0 author

19 February 2025

Background and Objectives: The pulmonary artery pulsatility index (PAPi) is an emerging marker of right ventricular (RV) injury but has not been well investigated in acute pulmonary embolism (PE) or chronic thromboembolic pulmonary hypertension (CTEP...

(This article belongs to the Section Pulmonology)
  • Article
  • Open Access
10 Citations
7,494 Views
15 Pages

A Comparison of the Efficacy and Safety of Denosumab and Zoledronic Acid in Patients with Bone Metastatic Breast Cancer Receiving CDK4/6 Inhibitor Therapy

  • İrem Öner,
  • Hicran Anık,
  • Bediz Kurt İnci,
  • Pınar Kubilay Tolunay and ,
  • Öztürk Ateş,
  • Ülkü Yalçıntaş Arslan and
  • Cengiz Karaçin
  • + 2 authors+ 0 author

19 February 2025

Background and Objectives: Bone metastases in patients can cause significant quality-of-life declines due to skeletal-related events (SREs). SRE is defined as the occurrence of radiotherapy for bone pain, pathologic fracture, bone surgery, spinal cor...

(This article belongs to the Section Oncology)
  • Review
  • Open Access
37 Citations
16,504 Views
18 Pages

Hypertension and Atrial Fibrillation: Bridging the Gap Between Mechanisms, Risk, and Therapy

  • Ibrahim Antoun,
  • Georgia R. Layton,
  • Ali Nizam,
  • Joseph Barker and ,
  • Ahmed Abdelrazik,
  • Mahmoud Eldesouky,
  • Abdulmalik Koya,
  • Edward Y. M. Lau,
  • Mustafa Zakkar and
  • Ghulam André Ng
  • + 6 authors+ 1 author

19 February 2025

Background and objectives: Atrial fibrillation (AF), the most prevalent sustained arrhythmia, poses a significant public health challenge due to its links with stroke, heart failure, and mortality. Hypertension, a primary modifiable cardiovascular ri...

(This article belongs to the Special Issue New Insights into Hypertension and the Cardiovascular System)
  • Review
  • Open Access
3 Citations
8,068 Views
13 Pages

Inferior Vestibular Neuritis: Diagnostic Criteria, Clinical Features, and Prognosis—A Focused Review

  • Gabriela Cornelia Musat,
  • Mihai Alexandru Preda,
  • Ionut Tanase,
  • Adina Zamfir Chiru Anton and ,
  • George G. Mitroi,
  • Ovidiu Musat,
  • Alina Lavinia Antoaneta Oancea and
  • Mihaela Roxana Mitroi
  • + 3 authors+ 0 author

19 February 2025

Purpose: This review aims to analyze the diagnostic methods used to evaluate inferior vestibular nerve neuritis. Methods: We performed an electronic search on the PubMed database for clinical studies investigating the diagnostic techniques used for i...

(This article belongs to the Section Surgery)
  • Article
  • Open Access
1 Citations
1,702 Views
14 Pages

Can Clinical, Psychological, and Cognitive Patient-Reported Outcome Measures (PROMs) Help to Discriminate Women with Fibromyalgia from Those with Other Localized/Regional Pain Conditions? A Diagnostic Accuracy Study

  • Margarita Cigarán-Mendez,
  • Ángela Tejera-Alonso,
  • Cristina Gómez-Calero,
  • César Fernández-de-las-Peñas and ,
  • Mónica López-Redondo,
  • Juan A. Valera-Calero,
  • Francisco G. Fernández-Palacios and
  • Juan C. Pacho-Hernández
  • + 3 authors+ 0 author

19 February 2025

Background and Objectives: The heterogeneous clinical manifestations of fibromyalgia syndrome have led to the revision of diagnostic criteria in the last decade. The aim of this study was to determine the capability of clinical, psychological, and co...

(This article belongs to the Section Psychiatry)
  • Review
  • Open Access
51 Citations
15,265 Views
19 Pages

The Role of Artificial Intelligence in Obesity Risk Prediction and Management: Approaches, Insights, and Recommendations

  • Lillian Huang,
  • Ellen N. Huhulea,
  • Elizabeth Abraham,
  • Raphael Bienenstock and ,
  • Esewi Aifuwa,
  • Rahim Hirani,
  • Atara Schulhof,
  • Raj K. Tiwari and
  • Mill Etienne
  • + 4 authors+ 0 author

19 February 2025

Greater than 650 million individuals worldwide are categorized as obese, which is associated with significant health, economic, and social challenges. Given its overlap with leading comorbidities such as heart disease, innovative solutions are necess...

(This article belongs to the Section Epidemiology & Public Health)
  • Article
  • Open Access
3 Citations
2,099 Views
13 Pages

Assessment of Pain, Diet, and Analgesic Use in Orthodontic Patients: An Observational Study

  • Bianca Maria Negruțiu,
  • Claudia Elena Staniș,
  • Ligia Luminița Vaida,
  • Abel Emanuel Moca and ,
  • Cristina Paula Costea,
  • Raluca Iurcov,
  • Alexandru Nicolae Pîrvan and
  • Marius Rus
  • + 3 authors+ 0 author

19 February 2025

Background/Objectives: Orthodontic treatment offers significant functional and aesthetic benefits, but it often causes discomfort, impacting patients’ daily activities, including diet and medication use. The primary aim of this observational st...

(This article belongs to the Special Issue Recent Advances in Orthodontics and Dental Medicine)
  • Article
  • Open Access
1,879 Views
14 Pages

Evaluation of Respiratory Intensive Care Experiences and Relationships with Nutritional Status Among Patients Admitted to the Intensive Care Unit

  • Murat Yildiz,
  • Deniz Celik,
  • Tarkan Ozdemir,
  • Kerem Ensarioglu and ,
  • Melek Cakir,
  • Tugce Dondu Savur,
  • Oral Mentes and
  • Mustafa Ozgur Cirik
  • + 3 authors+ 0 author

19 February 2025

Background and Objectives: This study aimed to evaluate patients’ experiences in the intensive care unit (ICU) setting and investigate whether there was a correlation between these experiences and their nutritional status. Materials and Methods...

(This article belongs to the Section Intensive Care/ Anesthesiology)
  • Systematic Review
  • Open Access
8 Citations
14,891 Views
12 Pages

Vitamin D Supplementation and Allergic Rhinitis: A Systematic Review and Meta-Analysis

  • Kei Kawada,
  • Chiemi Sato,
  • Tomoaki Ishida,
  • Yui Nagao and ,
  • Takaaki Yamamoto,
  • Kohei Jobu,
  • Yukihiro Hamada,
  • Yuki Izawa Ishizawa,
  • Keisuke Ishizawa and
  • Shinji Abe
  • + 5 authors+ 0 author

18 February 2025

Background and Objectives: Vitamin D supplementation is effective for allergic rhinitis; however, its usefulness is unclear. We conducted a systematic review and meta-analysis to examine the conditions in which vitamin D supplementation was effective...

(This article belongs to the Section Hematology and Immunology)
  • Article
  • Open Access
3 Citations
3,845 Views
12 Pages

18 February 2025

Background and Objectives: Chronic pelvic pain (CPP) is a common complication of pelvic inflammatory disease (PID). Although acupuncture has been increasingly used for the management of CPP, there is insufficient research to support the use of laser...

(This article belongs to the Special Issue Diagnosis and Treatment of Endometriosis: Priorities, Advances and Challenges)
  • Article
  • Open Access
2,283 Views
11 Pages

Incidence of and Risk Factors for Anti-PD-1/PD-L1- Associated Diarrhea and Colitis: A Retrospective Cohort Study of the Chinese Population

  • Wei Chen,
  • Yan Wang,
  • Mengyu Zhao,
  • Hong Zhang and ,
  • Ye Zong and
  • Xinyan Zhao
  • + 1 author+ 0 author

18 February 2025

Background and Objectives: The prevalence of and risk factors for immune checkpoint inhibitor-associated diarrhea and colitis (IMDC) in the Chinese population are unclear. This study aimed to estimate IMDC incidence and identify potential risk factor...

(This article belongs to the Section Gastroenterology & Hepatology)
  • Article
  • Open Access
2 Citations
2,485 Views
15 Pages

Robot-Assisted Approach to Diabetes Care Consultations: Enhancing Patient Engagement and Identifying Therapeutic Issues

  • Yuya Asada,
  • Tomomi Horiguchi,
  • Kunimasa Yagi,
  • Mako Komatsu and ,
  • Ayaka Yamashita,
  • Ren Ueta,
  • Naoto Yamaaki,
  • Mikifumi Shikida,
  • Shuichi Nishio and
  • Michiko Inagaki
  • + 5 authors+ 0 author

17 February 2025

Background and Objectives: Diabetes is a rapidly increasing global health challenge compounded by a critical shortage of diabetes care and education specialists. Robot-assisted diabetes care offers a cost-effective and scalable alternative to traditi...

(This article belongs to the Special Issue Advances in Clinical Diabetes, Obesity, and Metabolic Diseases)
  • Article
  • Open Access
3 Citations
2,569 Views
9 Pages

17 February 2025

Background and Objectives: This study evaluated the safety and efficacy of long-term indwelling self-expandable covered metallic stents (UVENTA; Taewoong Medical Co., Ltd., Seoul, Republic of Korea) used to manage benign and malignant ureteral strict...

(This article belongs to the Section Urology & Nephrology)
  • Review
  • Open Access
14 Citations
5,738 Views
15 Pages

Advances in Metabolic Bariatric Surgeries and Endoscopic Therapies: A Comprehensive Narrative Review of Diabetes Remission Outcomes

  • Wissam Ghusn,
  • Jana Zeineddine,
  • Richard S. Betancourt,
  • Aryan Gajjar and ,
  • Wah Yang,
  • Andrew G. Robertson and
  • Omar M. Ghanem
  • + 2 authors+ 0 author

17 February 2025

Background and Objectives: Type 2 diabetes (T2D), closely associated with obesity, contributes to increased morbidity and mortality due to complications such as cardiometabolic disease. This review aims to evaluate the effectiveness of metabolic and...

(This article belongs to the Section Surgery)
  • Article
  • Open Access
5 Citations
5,224 Views
15 Pages

Aerobic-Resistance Training with Royal Jelly Supplementation Has a Synergistic Effect on Paraoxonase 1 Changes and Liver Function in Women with MASLD

  • Roya Askari,
  • Nazanin Rabani,
  • Hamid Marefati,
  • Marzie Sadat Azarnive and ,
  • Matteo Pusceddu and
  • Gian Mario Migliaccio
  • + 1 author+ 0 author

17 February 2025

Background and Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a clinical pathological syndrome characterized by steatosis and fat accumulation in liver parenchymal cells in patients without a history of excessive alco...

(This article belongs to the Section Gastroenterology & Hepatology)
  • Article
  • Open Access
1 Citations
2,673 Views
9 Pages

Tibial Tuberosity–Tibial Intercondylar Midpoint Distance Can Be Interchangeably Measured on Axial CT and MRI: Retrospective Cross-Sectional Comparative Study

  • Dinko Nizić,
  • Marko Šimunović,
  • Jure Serdar,
  • Josip Vlaić and ,
  • Mario Josipović,
  • Ivan Levaj,
  • Igor Ivić-Hofman and
  • Mislav Jelić
  • + 3 authors+ 0 author

17 February 2025

Background and Objectives: It is unknown whether the tibial tuberosity–tibial intercondylar midpoint (TT–TIM) distance can be interchangeably measured on axial computed tomography (CT) and magnetic resonance imaging (MRI). The objective o...

(This article belongs to the Special Issue AI in Imaging—New Perspectives, 2nd Edition)
  • Review
  • Open Access
9 Citations
5,715 Views
13 Pages

Helicobacter pylori, Atherosclerosis, and Coronary Artery Disease: A Narrative Review

  • Angela Saviano,
  • Maria Rita Morabito Loprete,
  • Giulia Pignataro,
  • Andrea Piccioni and ,
  • Antonio Gasbarrini,
  • Francesco Franceschi and
  • Marcello Candelli
  • + 2 authors+ 0 author

16 February 2025

Coronary artery disease (CAD) is one of the leading causes of death worldwide, significantly contributing to mortality in both developed and developing nations. CAD arises from a combination of risk factors, including atherosclerosis, dyslipidemia, h...

(This article belongs to the Special Issue Editorial Board Members’ Collection Series: Gastrointestinal and Hepatic Diseases)
  • Article
  • Open Access
4 Citations
2,140 Views
19 Pages

Multidisciplinary Clinical Study on Retinal, Circulatory, and Respiratory Damage in Smoking-Dependent Subjects

  • Marcella Nebbioso,
  • Annarita Vestri,
  • Magda Gharbiya,
  • Mattia D’Andrea and ,
  • Matteo Calbucci,
  • Federico Pasqualotto,
  • Serena Esposito,
  • Alessandra D’Amico,
  • Valentina Castellani and
  • Alessandro Lambiase
  • + 7 authors+ 2 authors

16 February 2025

Background and Objectives: Cigarette smoking is a widely prevalent risk factor in the global population, despite its well-recognized systemic impact. In this pilot study, an association was hypothesized between alterations in hemorheological and resp...

(This article belongs to the Special Issue Retinopathies: A Challenge for Early Diagnosis, Innovative Treatments and Reliable Follow-Up)
  • Editorial
  • Open Access
1,134 Views
4 Pages

15 February 2025

The global burden of cardiovascular disease (CVD) continues to pose a significant challenge to healthcare systems worldwide [...]

(This article belongs to the Special Issue Novel Echocardiographic Techniques for the Assessment of Cardiovascular Disease)
  • Article
  • Open Access
4 Citations
10,691 Views
16 Pages

15 February 2025

Background and Objectives: Brain fog, characterized by cognitive difficulties such as memory impairment, lack of focus, and mental fatigue, is a common symptom reported during recovery from COVID-19, particularly in long COVID cases. This study explo...

(This article belongs to the Section Epidemiology & Public Health)
  • Review
  • Open Access
6 Citations
3,512 Views
10 Pages

Mathematical Modeling and Artificial Intelligence to Explore Connections Between Glaucoma and the Gut Microbiome

  • Madeline C. Rocks,
  • Priyanka Bhatnagar,
  • Alice Verticchio Vercellin,
  • Lorenzo Sala and ,
  • Brent Siesky,
  • Gal Antman,
  • Keren Wood,
  • Riccardo Sacco and
  • Alon Harris
  • + 4 authors+ 0 author

14 February 2025

Background and Objectives: Glaucoma is a major cause of irreversible blindness, with primary open-angle glaucoma (POAG) being the most prevalent form. While elevated intraocular pressure (IOP) is a well-known risk factor for POAG, emerging evidence s...

(This article belongs to the Section Ophthalmology)
  • Review
  • Open Access
2 Citations
6,023 Views
15 Pages

Sarcoidosis-Associated Pulmonary Hypertension

  • Yoshitaka Morimatsu,
  • Nobuhiro Tahara,
  • Masaki Okamoto,
  • Munehisa Bekki and ,
  • Atsuko Tahara,
  • Yoshiko Eto,
  • Tadahiro Kugai,
  • Yuki Koga,
  • Shoko Maeda-Ogata and
  • Yoshihiro Fukumoto
  • + 11 authors+ 6 authors

14 February 2025

Sarcoidosis is a granulomatous disorder of unknown etiology characterized by multisystem non-caseating granulomas. Pulmonary hypertension (PH) is a well-known complication of sarcoidosis and is associated with increased morbidity and mortality. The a...

(This article belongs to the Section Pulmonology)
  • Article
  • Open Access
3 Citations
3,994 Views
10 Pages

Evaluation of Asthma Course in Patients Hospitalized in Pediatric Intensive Care Unit Due to Severe Asthma Exacerbation

  • Ahmet Selmanoglu,
  • Hatice Irmak Celik,
  • Cankat Genis,
  • Esra Kockuzu and ,
  • Zeynep Sengul Emeksiz and
  • Emine Dibek Misirlioglu
  • + 1 author+ 0 author

14 February 2025

Background and Objectives: Childhood asthma represents a significant global public health issue and is the most common chronic disease among children. Hospitalization costs, especially for intensive care, are quite high. This study aimed to evaluate...

(This article belongs to the Section Pulmonology)
  • Article
  • Open Access
3,673 Views
18 Pages

Comparison of Standard Neoadjuvant Therapy and Total Neoadjuvant Therapy in Terms of Effectiveness in Patients Diagnosed with Locally Advanced Rectal Cancer

  • Ayberk Bayramgil,
  • Ahmet Bilici,
  • Ali Murat Tatlı,
  • Seda Kahraman and ,
  • Yunus Emre Altintas,
  • Fahri Akgul,
  • Musa Barış Aykan,
  • Jamshid Hamdard,
  • Sema Sezgin Göksu and
  • Ömer Fatih Ölmez
  • + 7 authors+ 2 authors

14 February 2025

Background/Objectives: The study aimed to compare the treatment effectiveness of patients with locally advanced rectal cancer undergoing standard neoadjuvant therapy or total neoadjuvant therapy. It also sought to identify prognostic factors for dise...

(This article belongs to the Section Oncology)
  • Case Report
  • Open Access
1 Citations
1,609 Views
5 Pages

Cutaneous Anguillulosis During Immunotherapy for Metastatic Renal Cell Carcinoma

  • Pierre Cornillon,
  • Marie Beguinot,
  • Denis Maillet,
  • Wafa Bouleftour and ,
  • Yanis Bouqallaba,
  • Pierre Flori,
  • Pauline Corbaux and
  • Guorong Li
  • + 3 authors+ 0 author

14 February 2025

Immunotherapy has been widely applied to treat metastatic renal cell cancer patients. Managing the side effects of immunotherapy can be a challenge. Here, we describe a rare presentation of cutaneous anguillulosis during immunotherapy. The patient ex...

(This article belongs to the Section Oncology)
  • Article
  • Open Access
2 Citations
3,060 Views
12 Pages

Atrial Fibrillation as an Independent Predictor of Myocardial Ischemia

  • Aris Bechlioulis,
  • Aidonis Rammos,
  • Athanassios Papadopoulos,
  • Paraskeni Zotou and ,
  • Sotiria Alexiou,
  • Areti Kekiopoulou,
  • Lampros K. Michalis,
  • Katerina K. Naka,
  • Chrissa Sioka and
  • Christos Katsouras
  • + 5 authors+ 0 author

14 February 2025

Background and Objectives: Atrial fibrillation (AF) and coronary artery disease (CAD) are highly prevalent cardiovascular conditions. This study investigated the role of AF in myocardial ischemia, as assessed with myocardial perfusion imaging (MPI),...

  • Article
  • Open Access
1 Citations
3,812 Views
14 Pages

14 February 2025

Background and Objectives: The development of acute kidney injury (AKI) in the post-cardiopulmonary resuscitation (post-CPR) period is a common pathology that has not been adequately investigated but contributes significantly to morbidity and mortali...

(This article belongs to the Section Intensive Care/ Anesthesiology)
  • Article
  • Open Access
5 Citations
3,685 Views
10 Pages

14 February 2025

Background and Objectives: Postoperative delirium (POD) is a transient but significant complication in geriatric patients following hip or femur surgery. POD occurs in 19–65% of patients after hip surgeries, with notable risks associated with a...

(This article belongs to the Special Issue Anesthesia and Analgesia in Surgical Practice)
  • Article
  • Open Access
12 Citations
3,624 Views
18 Pages

Ameliorative Effect of N-Acetylcysteine Against 5-Fluorouracil-Induced Cardiotoxicity via Targeting TLR4/NF-κB and Nrf2/HO-1 Pathways

  • Omer Abdelbagi,
  • Medhat Taha,
  • Abdullah G. Al-Kushi,
  • Mohammad Ahmad Alobaidy and ,
  • Tourki A. S. Baokbah,
  • Hatem A. Sembawa,
  • Zohor Asaad Azher,
  • Rami Obaid,
  • Omar Babateen and
  • Hesham A. Malak
  • + 7 authors+ 2 authors

14 February 2025

Background and Objectives: 5-Fluorouracil (5-FU) is a widely prescribed and effective chemotherapeutic drug, but its cardiotoxic side effects pose a significant challenge to its use. Identifying a protective agent that does not affect its anticancer...

(This article belongs to the Section Pharmacology)
  • Article
  • Open Access
4 Citations
2,772 Views
8 Pages

Telehealth—An Environmentally Friendly Way to Take Care of Patients with Inflammatory Bowel Disease

  • Srdjan Marković,
  • Djordje Kralj,
  • Tamara Knežević Ivanovski and
  • Petar Svorcan

14 February 2025

Background and Objectives: On 11 March 2020, our hospital adapted to the COVID-19 pandemic by becoming a temporary COVID-19 facility, leading to the suspension or delegation of non-COVID-19 services. Among the international IBD community, there were...

  • Article
  • Open Access
5 Citations
2,643 Views
14 Pages

Echocardiographic Left Ventricular Function in the Third Year After COVID-19 Hospitalization: A Follow-Up Pilot Study in South-East of Romania

  • Constantin-Marinel Vlase,
  • Cristian Gutu,
  • Roxana Elena Bogdan Goroftei,
  • Andreea Boghean and ,
  • Traian Florin Daniel Iordachi,
  • Anca-Adriana Arbune and
  • Manuela Arbune
  • + 2 authors+ 0 author

14 February 2025

Background and Objectives: Cardiac involvement in COVID-19 has been confirmed during the acute stage of the infection. However, the prevalence and spectrum of post-infectious cardiac dysfunction remain incompletely clarified. The objective of our stu...

(This article belongs to the Special Issue New Insights into Heart Failure)
  • Case Report
  • Open Access
3,780 Views
13 Pages

14 February 2025

Nasopharyngeal carcinoma (NPC) with paraneoplastic dermatomyositis (DM) is an exceptionally rare clinical phenomenon, particularly among European populations. This case report details a 46-year-old woman initially diagnosed with DM, later confirmed t...

(This article belongs to the Section Dermatology)
  • Systematic Review
  • Open Access
8 Citations
11,443 Views
17 Pages

13 February 2025

Background and Objective: According to international guidelines, glucosamine and chondroitin, regarded as slow-acting drugs for osteoarthritis (SYSADOAs), have been first-line treatments for knee osteoarthritis (OA); however, their efficacies remain...

(This article belongs to the Special Issue Updates on Risk Factors, Prevention and Treatment of Knee Disease)
  • Article
  • Open Access
1,826 Views
18 Pages

Immunological Landscape of Non-Melanoma Skin Neoplasms: Role of CTLA4+IFN-γ+ Lymphocytes in Tumor Microenvironment Suppression

  • Silvana Karabatić Knezović,
  • Dora Knezović,
  • Jelena Ban,
  • Antonela Matana and ,
  • Neira Puizina Ivić,
  • Merica Glavina Durdov,
  • Mladen Merćep and
  • Irena Drmić Hofman
  • + 3 authors+ 0 author

13 February 2025

Background and Objectives: This study explores the immunological landscapes of non-melanoma skin neoplasms (NMSNs), specifically keratoacanthoma (KA), squamous cell carcinoma (SCC), and common warts (VV). Although benign, KA shares histological simil...

(This article belongs to the Section Oncology)
  • Article
  • Open Access
5 Citations
3,248 Views
15 Pages

Inhibiting MiR-33a-3p Expression Fails to Enhance ApoAI-Mediated Cholesterol Efflux in Pro-Inflammatory Endothelial Cells

  • Kun Huang,
  • Achala Pokhrel,
  • Jing Echesabal-Chen,
  • Justin Scott and ,
  • Terri Bruce,
  • Hanjoong Jo and
  • Alexis Stamatikos
  • + 2 authors+ 0 author

13 February 2025

Background and Objectives: Atherosclerosis is an inflammatory condition that results in cholesterol accumulating within vessel wall cells. Atherosclerotic cardiovascular disease is the leading cause of mortality worldwide due to this disease being a...

(This article belongs to the Special Issue Early Diagnosis and Treatment of Cardiovascular Disease)
  • Review
  • Open Access
2 Citations
9,821 Views
18 Pages

An Updated Review on the Use of Noninvasive Respiratory Supports in the Management of Severe Asthma Exacerbations

  • Giuseppe Cuttone,
  • Luigi La Via,
  • Federico Pappalardo,
  • Massimiliano Sorbello and ,
  • Daniele Salvatore Paternò,
  • Matteo Piattoli,
  • Cesare Gregoretti and
  • Giovanni Misseri
  • + 3 authors+ 0 author

13 February 2025

Asthma is a reversible clinical condition characterized by airway obstruction due to bronchial smooth muscle contraction, inflammation and a hypersecretive state. Severe asthma exacerbations (SAE) may be a part of the natural history of this conditio...

(This article belongs to the Section Intensive Care/ Anesthesiology)
  • Article
  • Open Access
4 Citations
3,083 Views
11 Pages

Is the Neutrophil-to-Lymphocyte Ratio a Predictive Factor of Pathological Complete Response in Egyptian Breast Cancer Patients Treated with Neoadjuvant Chemotherapy?

  • Naglaa F. Ebaid,
  • Khaled S. Abdelkawy,
  • Amira S. A. Said,
  • Mohamad M. Al-Ahmad and ,
  • Mohamed A. Shehata,
  • Heba F. Salem and
  • Raghda R. S. Hussein
  • + 2 authors+ 0 author

13 February 2025

Background and Objectives: The role of the neutrophil-to-lymphocyte ratio (NLR) as a predictor of response in breast cancers after neoadjuvant chemotherapy is controversial. This study aims to explore the relationship of NLR with pathological complet...

(This article belongs to the Special Issue Future Trends in Breast Cancer Management)
  • Review
  • Open Access
4 Citations
7,718 Views
17 Pages

The Role of Medical Therapies in the Management of Cervical Intraepithelial Neoplasia: A Narrative Review

  • Ioana Cristina Rotar,
  • Dan Boitor Borza,
  • Adelina Staicu,
  • Iulian Gabriel Goidescu and ,
  • Georgiana Irina Nemeti,
  • Popa Iulia,
  • Melinda Ildiko Mitranovici,
  • Mureșan Daniel and
  • Petca Aida
  • + 4 authors+ 0 author

13 February 2025

Cervical cancer and its precursors (cervical intraepithelial neoplasia (CIN)) represent a current major public health concern. Currently, the treatment of choice for patients with HSILs (high-grade intraepithelial lesions) is surgical treatment&mdash...

(This article belongs to the Special Issue Diagnosis and Treatment of Cervical Cancer)
  • Review
  • Open Access
17 Citations
18,881 Views
22 Pages

Management of Deep Neck Infection Associated with Descending Necrotizing Mediastinitis: A Scoping Review

  • Bogdan Mihail Cobzeanu,
  • Liliana Moisii,
  • Octavian Dragos Palade,
  • Mihai Ciofu and ,
  • Florentina Severin,
  • Mihai Dumitru,
  • Luminita Radulescu,
  • Cristian Martu,
  • Mihail Dan Cobzeanu and
  • Geanina Bandol
  • + 5 authors+ 0 author

12 February 2025

Deep neck infection is a pathology at the border of two specialties, otorhinolaryngology and maxillofacial surgery, and represents a medico-surgical emergency. In terms of its evolution, it can extend to the level of the thorax and result in mediasti...

(This article belongs to the Special Issue Current Trends in Otorhinolaryngology and Head and Neck Pathology: 2nd Edition)
  • Article
  • Open Access
2 Citations
1,827 Views
11 Pages

12 February 2025

Background and Objectives: An atrial high-rate episode (AHRE) is defined according to the European Society of Cardiology (ESC) guidelines as a heart rate of ≥175 bpm lasting at least 5 min. This study aimed to evaluate whether neuron-specific enol...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
2 Citations
4,713 Views
11 Pages

12 February 2025

Background and Objectives: Added sugar usage has become an important public health issue nowadays. Therefore, the interest in studying the cognitive and emotional effects associated with sugar consumption has increased. The present study aimed to inv...

(This article belongs to the Section Epidemiology & Public Health)
  • Article
  • Open Access
4 Citations
4,623 Views
13 Pages

MOTS-c Levels and Sarcopenia Risk in Chronic Peritoneal Dialysis Patients: A Pilot Study

  • Mariateresa Zicarelli,
  • Marta Greco,
  • Stefanos Roumeliotis,
  • Maria Elisa Lo Vasco and ,
  • Francesco Dragone,
  • Christodoula Kourtidou,
  • Ioannis Alekos,
  • Roberta Misiti,
  • Daniela Patrizia Foti and
  • Davide Bolignano
  • + 8 authors+ 3 authors

12 February 2025

Background and Objectives: Sarcopenia is exceedingly frequent in end-stage kidney disease (ESKD) patients on dialysis, including those undergoing peritoneal dialysis (PD), and is of multifactorial origin. MOTS-c is a mitochondrial-derived peptide tha...

(This article belongs to the Section Urology & Nephrology)
  • Article
  • Open Access
10 Citations
3,551 Views
9 Pages

12 February 2025

Background and Objectives: The use of additional biomarkers to predict clinical course in diabetic ketoacidosis (DKA) is becoming increasingly important. The aim of this study was to investigate the relationship between interleukin-6 (IL-6) levels an...

(This article belongs to the Section Intensive Care/ Anesthesiology)
  • Correction
  • Open Access
736 Views
1 Page

12 February 2025

In the original publication [...]

  • Article
  • Open Access
4 Citations
3,845 Views
13 Pages

12 February 2025

Objectives: Spondyloarthritis (SpA) is a chronic inflammatory arthritis that mainly affects the sacroiliac joints and spine. Despite effective biological treatments, persistent pain is common in SpA patients, potentially due to central sensitization...

(This article belongs to the Section Hematology and Immunology)
  • Article
  • Open Access
9 Citations
3,075 Views
16 Pages

The Relationship Between Thrombophilia and Modifications in First-Trimester Prenatal Screening Markers

  • Viorela Romina Murvai,
  • Casandra-Maria Radu,
  • Radu Galiș,
  • Timea Claudia Ghitea and ,
  • Anca-Florina Tătaru-Copos,
  • Alexandra-Alina Vesa and
  • Anca Huniadi
  • + 2 authors+ 0 author

12 February 2025

Background and Objective: Thrombophilia significantly increases the risk of complications like recurrent pregnancy loss, preeclampsia, IUGR, and stillbirth. Objective: This study aimed to evaluate the impact of inherited thrombophilic mutations on fi...

(This article belongs to the Section Obstetrics and Gynecology)
  • Article
  • Open Access
3 Citations
3,889 Views
17 Pages

Correlation Between the Clinical and Histopathological Results in Experimental Sciatic Nerve Defect Surgery

  • Andrei Marin,
  • Vlad Herlea,
  • Alice Bancu,
  • Carmen Giuglea and ,
  • Dana Antonia Țăpoi,
  • Ana Maria Ciongariu,
  • Georgiana Gabriela Marin,
  • Silviu Adrian Marinescu,
  • Nicoleta Amalia Dobrete and
  • Maria Sajin
  • + 8 authors+ 3 authors

11 February 2025

Background and Objectives: Peripheral nerve defect regeneration is subject to ongoing research regarding the use of conduits associated with various cells or molecules. This article aims to correlate histopathological and clinical outcomes at the end...

(This article belongs to the Special Issue Recent Advances in Plastic and Reconstructive Surgery)
  • Article
  • Open Access
1,921 Views
10 Pages

11 February 2025

Background and Objectives: This study aims to evaluate neurosurgery consultations for elderly patients during and following the COVID-19 pandemic. Materials and Methods: This study included patients aged 65 and older who were hospitalized in non-neur...

(This article belongs to the Section Surgery)
  • Article
  • Open Access
1 Citations
1,885 Views
16 Pages

Echocardiographic Findings in Jordanian Atrial Fibrillation Patients: Analysis from Jo-Fib Study

  • Zaid A. Abdulelah,
  • Kais Al Balbissi,
  • Mohammad Al-Dqour,
  • Ayman Hammoudeh and
  • Ahmed A. Abdulelah

11 February 2025

Background and Objectives: Atrial fibrillation (AF) carries a huge socioeconomic burden as it is the most encountered cardiac arrhythmia with a significant morbidity. Echocardiographic (Echo) imaging is of monumental value in providing insight into a...

(This article belongs to the Special Issue Clinical Cardiology in a New Era: Navigating Challenges and Embracing Opportunities)

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Medicina - ISSN 1648-9144