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Medicina, Volume 61, Issue 2

2025 February - 197 articles

Cover Story: Nicotinamide is a derivate of vitamin B3 and is the precursor of NAD, a key coenzyme involved in several cellular reactions. NAM is often consumed daily and is endogenously produced by tryptophan. Additionally, NAM supplementation (500 mg–1g/die) can efficiently protect cells from oxidative stress, DNA damages, inflammation and aging. Indeed, NAM inhibits two energy-demanding enzymes—PARP1 and SIRT1—leading to NAD restoration, which is fundamental for the DNA damage repair system. Moreover, NAM can reduce the release of proinflammatory cytokines and reactive oxygen species (ROS), enhancing the repair of DNA and the recovery of the cell cycle. View this paper
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Articles (197)

  • Article
  • Open Access
1 Citations
2,100 Views
12 Pages

Pulmonary Artery Pulsatility Index in Acute and Chronic Pulmonary Embolism

  • Mads Dam Lyhne,
  • Eugene Yuriditsky,
  • Vasileios Zochios,
  • Simone Juel Dragsbaek,
  • Jacob Valentin Hansen,
  • Mads Jønsson Andersen,
  • Søren Mellemkjær,
  • Christopher Kabrhel and
  • Asger Andersen

19 February 2025

Background and Objectives: The pulmonary artery pulsatility index (PAPi) is an emerging marker of right ventricular (RV) injury but has not been well investigated in acute pulmonary embolism (PE) or chronic thromboembolic pulmonary hypertension (CTEP...

  • Article
  • Open Access
3 Citations
5,313 Views
15 Pages

A Comparison of the Efficacy and Safety of Denosumab and Zoledronic Acid in Patients with Bone Metastatic Breast Cancer Receiving CDK4/6 Inhibitor Therapy

  • İrem Öner,
  • Hicran Anık,
  • Bediz Kurt İnci,
  • Pınar Kubilay Tolunay,
  • Öztürk Ateş,
  • Ülkü Yalçıntaş Arslan and
  • Cengiz Karaçin

19 February 2025

Background and Objectives: Bone metastases in patients can cause significant quality-of-life declines due to skeletal-related events (SREs). SRE is defined as the occurrence of radiotherapy for bone pain, pathologic fracture, bone surgery, spinal cor...

  • Review
  • Open Access
17 Citations
9,804 Views
18 Pages

Hypertension and Atrial Fibrillation: Bridging the Gap Between Mechanisms, Risk, and Therapy

  • Ibrahim Antoun,
  • Georgia R. Layton,
  • Ali Nizam,
  • Joseph Barker,
  • Ahmed Abdelrazik,
  • Mahmoud Eldesouky,
  • Abdulmalik Koya,
  • Edward Y. M. Lau,
  • Mustafa Zakkar and
  • Ghulam André Ng
  • + 1 author

19 February 2025

Background and objectives: Atrial fibrillation (AF), the most prevalent sustained arrhythmia, poses a significant public health challenge due to its links with stroke, heart failure, and mortality. Hypertension, a primary modifiable cardiovascular ri...

  • Review
  • Open Access
1 Citations
4,761 Views
13 Pages

Inferior Vestibular Neuritis: Diagnostic Criteria, Clinical Features, and Prognosis—A Focused Review

  • Gabriela Cornelia Musat,
  • Mihai Alexandru Preda,
  • Ionut Tanase,
  • Adina Zamfir Chiru Anton,
  • George G. Mitroi,
  • Ovidiu Musat,
  • Alina Lavinia Antoaneta Oancea and
  • Mihaela Roxana Mitroi

19 February 2025

Purpose: This review aims to analyze the diagnostic methods used to evaluate inferior vestibular nerve neuritis. Methods: We performed an electronic search on the PubMed database for clinical studies investigating the diagnostic techniques used for i...

  • Article
  • Open Access
1,245 Views
14 Pages

Can Clinical, Psychological, and Cognitive Patient-Reported Outcome Measures (PROMs) Help to Discriminate Women with Fibromyalgia from Those with Other Localized/Regional Pain Conditions? A Diagnostic Accuracy Study

  • Margarita Cigarán-Mendez,
  • Ángela Tejera-Alonso,
  • Cristina Gómez-Calero,
  • César Fernández-de-las-Peñas,
  • Mónica López-Redondo,
  • Juan A. Valera-Calero,
  • Francisco G. Fernández-Palacios and
  • Juan C. Pacho-Hernández

19 February 2025

Background and Objectives: The heterogeneous clinical manifestations of fibromyalgia syndrome have led to the revision of diagnostic criteria in the last decade. The aim of this study was to determine the capability of clinical, psychological, and co...

  • Review
  • Open Access
22 Citations
11,058 Views
19 Pages

The Role of Artificial Intelligence in Obesity Risk Prediction and Management: Approaches, Insights, and Recommendations

  • Lillian Huang,
  • Ellen N. Huhulea,
  • Elizabeth Abraham,
  • Raphael Bienenstock,
  • Esewi Aifuwa,
  • Rahim Hirani,
  • Atara Schulhof,
  • Raj K. Tiwari and
  • Mill Etienne

19 February 2025

Greater than 650 million individuals worldwide are categorized as obese, which is associated with significant health, economic, and social challenges. Given its overlap with leading comorbidities such as heart disease, innovative solutions are necess...

  • Article
  • Open Access
2 Citations
1,545 Views
13 Pages

Assessment of Pain, Diet, and Analgesic Use in Orthodontic Patients: An Observational Study

  • Bianca Maria Negruțiu,
  • Claudia Elena Staniș,
  • Ligia Luminița Vaida,
  • Abel Emanuel Moca,
  • Cristina Paula Costea,
  • Raluca Iurcov,
  • Alexandru Nicolae Pîrvan and
  • Marius Rus

19 February 2025

Background/Objectives: Orthodontic treatment offers significant functional and aesthetic benefits, but it often causes discomfort, impacting patients’ daily activities, including diet and medication use. The primary aim of this observational st...

  • Article
  • Open Access
981 Views
14 Pages

Evaluation of Respiratory Intensive Care Experiences and Relationships with Nutritional Status Among Patients Admitted to the Intensive Care Unit

  • Murat Yildiz,
  • Deniz Celik,
  • Tarkan Ozdemir,
  • Kerem Ensarioglu,
  • Melek Cakir,
  • Tugce Dondu Savur,
  • Oral Mentes and
  • Mustafa Ozgur Cirik

19 February 2025

Background and Objectives: This study aimed to evaluate patients’ experiences in the intensive care unit (ICU) setting and investigate whether there was a correlation between these experiences and their nutritional status. Materials and Methods...

  • Systematic Review
  • Open Access
3 Citations
9,487 Views
12 Pages

Vitamin D Supplementation and Allergic Rhinitis: A Systematic Review and Meta-Analysis

  • Kei Kawada,
  • Chiemi Sato,
  • Tomoaki Ishida,
  • Yui Nagao,
  • Takaaki Yamamoto,
  • Kohei Jobu,
  • Yukihiro Hamada,
  • Yuki Izawa Ishizawa,
  • Keisuke Ishizawa and
  • Shinji Abe

18 February 2025

Background and Objectives: Vitamin D supplementation is effective for allergic rhinitis; however, its usefulness is unclear. We conducted a systematic review and meta-analysis to examine the conditions in which vitamin D supplementation was effective...

  • Article
  • Open Access
2,481 Views
12 Pages

18 February 2025

Background and Objectives: Chronic pelvic pain (CPP) is a common complication of pelvic inflammatory disease (PID). Although acupuncture has been increasingly used for the management of CPP, there is insufficient research to support the use of laser...

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Medicina - ISSN 1648-9144