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Current Issues in Molecular Biology, Volume 45, Issue 6

June 2023 - 46 articles

Cover Story: Damage to the spinal cord is a devastating process that leads to the failure of motor, sensory and autonomic functions and for which, unfortunately, there is currently no effective treatment. One of the most promising approaches in the treatment of spinal cord injury is cell therapy. Mesenchymal stromal cells (MSCs) stand out amongst a large number of investigated cells. MSCs participate in the regeneration of damaged tissue in two main ways, directly with their ability to differentiate, so they can replace damaged cells in the tissue, or indirectly using the paracrine effect. In this case, MSCs serve as a source of bioactive molecules and growth factors, as well as extracellular vesicles, so they exhibit their immunomodulating, angiogenic, and neuroprotective effects at the site of injury. View this paper
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Articles (46)

  • Article
  • Open Access
5 Citations
3,809 Views
17 Pages

TPDM6315 is an antipyretic Thai herbal recipe that contains several herbs with anti-inflammatory and anti-obesity activities. This study aimed to investigate the anti-inflammatory effects of TPDM6315 extracts in lipopolysaccharide (LPS)-induced RAW26...

  • Article
  • Open Access
1 Citations
3,193 Views
16 Pages

Clinical prevention is of utmost importance for the management of periodontal diseases. Periodontal disease starts with an inflammatory response in the gingival tissue, and results in alveolar bone destruction and subsequent tooth loss. This study ai...

  • Article
  • Open Access
4 Citations
2,994 Views
25 Pages

Metabolic Deregulation in Pulmonary Hypertension

  • Rajamma Mathew,
  • Sanda Iacobas,
  • Jing Huang and
  • Dumitru Andrei Iacobas

The high morbidity and mortality rate of pulmonary arterial hypertension (PAH) is partially explained by metabolic deregulation. The present study complements our previous publication in “Genes” by identifying significant increases of the...

  • Brief Report
  • Open Access
2 Citations
2,404 Views
9 Pages

Interspecific hybridization is widespread for sunflowers, both in wild populations and commercial breeding. One of the most common species that can efficiently cross with Helianthus annuus is the Silverleaf sunflower—Helianthus argophyllus...

  • Review
  • Open Access
28 Citations
7,248 Views
15 Pages

Adenovirus as a Vector and Oncolytic Virus

  • Wataru Matsunaga and
  • Akinobu Gotoh

Adenoviral vectors, both oncolytic viruses and gene delivery vectors, are among the earliest approved and commercialised vectors for gene therapy. Adenoviruses have high cytotoxicity and immunogenicity. Therefore, lentiviruses or adeno-associated vir...

  • Communication
  • Open Access
1 Citations
2,809 Views
12 Pages

Molecular Detection of Nosema spp. in Three Eco Regions of Slovakia

  • Beáta Hurná,
  • Monika Sučik,
  • Martin Staroň,
  • Štefan Tutka,
  • Zuzana Maková,
  • Richard Galajda and
  • Alexandra Valenčáková

Microsporidia are unicellular obligate intracellular parasitic fungi that infect a wide range of vertebrates and invertebrates. There are two known species of microsporidia infecting honey bees in Slovakia- first Nosema apis and also Nosema ceranae....

  • Article
  • Open Access
3 Citations
2,471 Views
18 Pages

Genetic Dissection of Salt Tolerance and Yield Traits of Geng (japonica) Rice by Selective Subspecific Introgression

  • Simin Li,
  • Ting Feng,
  • Chenyang Zhang,
  • Fanlin Zhang,
  • Hua Li,
  • Yanjun Chen,
  • Lunping Liang,
  • Chaopu Zhang,
  • Wei Zeng and
  • Erbao Liu
  • + 3 authors

Salinity is a major factor limiting rice productivity, and developing salt-tolerant (ST) varieties is the most efficient approach. Seventy-eight ST introgression lines (ILs), including nine promising lines with improved ST and yield potential (YP), w...

  • Article
  • Open Access
5 Citations
3,263 Views
18 Pages

Large-Scale Production of Anti-RNase A VHH Expressed in pyrG Auxotrophic Aspergillus oryzae

  • Elif Karaman,
  • Alp Ertunga Eyüpoğlu,
  • Lena Mahmoudi Azar and
  • Serdar Uysal

Nanobodies, also referred to as VHH antibodies, are the smallest fragments of naturally produced camelid antibodies and are ideal affinity reagents due to their remarkable properties. They are considered an alternative to monoclonal antibodies (mAbs)...

  • Review
  • Open Access
7 Citations
4,573 Views
15 Pages

Kidney tumors comprise a broad spectrum of different histopathological entities, with more than 0.4 million newly diagnosed cases each year, mostly in middle-aged and older men. Based on the description of the 2022 World Health Organization (WHO) cla...

  • Review
  • Open Access
19 Citations
4,131 Views
14 Pages

Polymorphism of Genes and Their Impact on Beef Quality

  • Piotr Kostusiak,
  • Jan Slósarz,
  • Marcin Gołębiewski,
  • Grzegorz Grodkowski and
  • Kamila Puppel

The single-nucleotide polymorphism (SNP) form of genes is a valuable source of information regarding their suitability for use as specific markers of desirable traits in beef cattle breeding. For several decades, breeding work focused on improving pr...

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Curr. Issues Mol. Biol. - ISSN 1467-3045