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Current Issues in Molecular Biology, Volume 45, Issue 6

June 2023 - 46 articles

Cover Story: Damage to the spinal cord is a devastating process that leads to the failure of motor, sensory and autonomic functions and for which, unfortunately, there is currently no effective treatment. One of the most promising approaches in the treatment of spinal cord injury is cell therapy. Mesenchymal stromal cells (MSCs) stand out amongst a large number of investigated cells. MSCs participate in the regeneration of damaged tissue in two main ways, directly with their ability to differentiate, so they can replace damaged cells in the tissue, or indirectly using the paracrine effect. In this case, MSCs serve as a source of bioactive molecules and growth factors, as well as extracellular vesicles, so they exhibit their immunomodulating, angiogenic, and neuroprotective effects at the site of injury. View this paper
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Articles (46)

  • Review
  • Open Access
9 Citations
4,498 Views
17 Pages

Atopic dermatitis (AD) is a chronic inflammatory skin disease with a high prevalence in the developed countries. It is associated with atopic and non-atopic diseases, and its close correlation with atopic comorbidities has been genetically demonstrat...

  • Review
  • Open Access
6 Citations
3,293 Views
17 Pages

Heme (Fe2+-protoporphyrin IX) is a pigment of life, and as a prosthetic group in several hemoproteins, it contributes to diverse critical cellular processes. While its intracellular levels are tightly regulated by networks of heme-binding proteins (H...

  • Review
  • Open Access
2 Citations
3,318 Views
18 Pages

Spinal cord injury (SCI) is a destructive condition that results in lasting neurological damage resulting in disruption of the connection between the central nervous system and the rest of the body. Currently, there are several approaches in the trea...

  • Article
  • Open Access
16 Citations
8,327 Views
16 Pages

Cymbopogon citratus Essential Oil: Extraction, GC–MS, Phytochemical Analysis, Antioxidant Activity, and In Silico Molecular Docking for Protein Targets Related to CNS

  • Ana G. Cortes-Torres,
  • Guiee N. López-Castillo,
  • Josefina L. Marín-Torres,
  • Roberto Portillo-Reyes,
  • Felix Luna,
  • Beatriz E. Baca,
  • Jesús Sandoval-Ramírez and
  • Alan Carrasco-Carballo

This study analyzed the chemical composition of Cymbopogon citratus essential oil from Puebla, México, assessed its antioxidant activity, and evaluated in silico protein–compound interactions related to central nervous system (CNS) physi...

  • Article
  • Open Access
1 Citations
2,356 Views
19 Pages

Study of The Molecular Nature of Congenital Cataracts in Patients from The Volga–Ural Region

  • Irina Khidiyatova,
  • Indira Khidiyatova,
  • Rena Zinchenko,
  • Andrey Marakhonov,
  • Alexandra Karunas,
  • Svetlana Avkhadeeva,
  • Marat Aznzbaev and
  • Elza Khusnutdinova

Hereditary cataracts are characterized by significant clinical and genetic heterogeneity, which can pose challenges for early DNA diagnosis. To comprehensively address this problem, it is essential to investigate the epidemiology of the disease, perf...

  • Article
  • Open Access
6 Citations
4,589 Views
13 Pages

Bactericidal Mechanisms of Chlorine Dioxide against Beta-Hemolytic Streptococcus CMCC 32210

  • Huan Liu,
  • Jingju Zhang,
  • Jing Liu,
  • Guangjie Cao,
  • Fei Xu and
  • Xiubo Li

Chlorine dioxide is a globally recognized green and efficient disinfectant. This study aims to investigate the bactericidal mechanism of chlorine dioxide using beta-hemolytic Streptococcus (BHS) CMCC 32210 as a representative strain. BHS was exposed...

  • Review
  • Open Access
6 Citations
3,350 Views
14 Pages

Tezosentan is a vasodilator drug that was originally developed to treat pulmonary arterial hypertension. It acts by inhibiting endothelin (ET) receptors, which are overexpressed in many types of cancer cells. Endothelin-1 (ET1) is a substance produce...

  • Review
  • Open Access
7 Citations
3,456 Views
19 Pages

Asthma is considered a chronic inflammatory disorder associated with airway hyperresponsiveness (AHR). Increased oxidative stress (OS) is a clinical feature of asthma, which promotes the inflammatory responses in bronchial/airway epithelial cells. Sm...

  • Article
  • Open Access
9 Citations
4,116 Views
15 Pages

Potential Diagnostic Value of Salivary Tumor Markers in Breast, Lung and Ovarian Cancer: A Preliminary Study

  • Lyudmila V. Bel’skaya,
  • Elena A. Sarf,
  • Alexandra I. Loginova,
  • Dmitry M. Vyushkov and
  • En Djun Choi

The aim of the study was to determine the content of tumor markers for breast, lung and ovarian cancer in saliva, as well as for benign diseases of the corresponding organs and in the control group, and to evaluate their diagnostic significance. Stri...

  • Article
  • Open Access
7 Citations
7,467 Views
13 Pages

Hair Growth Effect of DN106212 in C57BL/6 Mouse and Its Network Pharmacological Mechanism of Action

  • Ji Yun Baek,
  • Byoung Ha Kim,
  • Dong-Wook Kim,
  • Won-Yung Lee,
  • Chang Eop Kim,
  • Hyun-Young Kim,
  • Jaesung Pyo,
  • Eun-Seok Park and
  • Ki Sung Kang

Centipeda minima (CMX) has been widely investigated using network pharmacology and clinical studies for its effects on hair growth via the JAK/STAT signaling pathway. Human hair follicle papilla cells exhibit hair regrowth through the expression of W...

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Curr. Issues Mol. Biol. - ISSN 1467-3045