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Current Issues in Molecular Biology, Volume 45, Issue 2

February 2023 - 63 articles

Cover Story: Red wine polyphenols include ones present in grapes as well as new polyphenols formed during the winemaking process. In red wine, the most important groups, and their representatives, are flavanols (catechin), stilbenes (trans-resveratrol), flavonols (quercetin), anthocyanins (malvidin-3-O-glucoside), and hydroxybenzoic acids (gallic acid). Many in vitro and in vivo studies have been conducted on the evaluation of the health effects of red wine polyphenols on cancer chemopreventive activities, neuroprotective effects, and their impact on cardiovascular diseases or gut microbiota in humans. In assessing the positive results of these studies, it can be concluded that there is high potential in the polyphenols of red wine; however, how to employ this potential in the most efficient way must be considered. View this paper
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Articles (63)

  • Article
  • Open Access
12 Citations
3,060 Views
14 Pages

Neuroprotective Effects of Geopung-Chunghyuldan Based on Its Salvianolic Acid B Content Using an In Vivo Stroke Model

  • Han-Gyul Lee,
  • Seungwon Kwon,
  • Sang-Kwan Moon,
  • Seung-Yeon Cho,
  • Seong-Uk Park,
  • Woo-Sang Jung,
  • Jung-Mi Park,
  • Chang-Nam Ko and
  • Ki-Ho Cho

13 February 2023

Background: Geopung-Chunghyuldan (GCD) has neuroprotective properties. Salviae miltiorrhizae Radix plays an essential role in GCD’s effect. The Salviae miltiorrhizae Radix marker compound is salvianolic acid B; however, its content is not unifo...

  • Article
  • Open Access
5 Citations
2,373 Views
12 Pages

13 February 2023

Natural and synthetic chalcones exhibit anti-inflammatory, antitumoral, antibacterial, antifungal, antimalarial, and antitubercular activities. Isodorsmanin A (IDA), a chalcone, is a well-known constituent of the dried seeds of Psoralea corylifolia L...

  • Article
  • Open Access
18 Citations
3,945 Views
14 Pages

13 February 2023

Background: Hesperetin has been reported to have anticancer properties. However, the molecular mechanisms underlying its action on leukemia cells remain unclear. This in vitro study evaluated the possible mechanisms of hesperetin in leukemia cells (H...

  • Article
  • Open Access
7 Citations
2,564 Views
17 Pages

12 February 2023

ATP-binding cassette (ABC) transporters are involved in transporting multiple substrates, such as toxins, and may be important for the survival of Trichoderma when encountering biotic toxins. In this study, genome searching revealed that there are 44...

  • Review
  • Open Access
6 Citations
6,077 Views
32 Pages

9 February 2023

Prostate cancer (PCa) remains both a global health burden and a scientific challenge. We present a review of the molecular targets driving current drug discovery to fight this disease. Moreover, the preventable nature of most PCa cases represents an...

  • Review
  • Open Access
5 Citations
3,839 Views
17 Pages

The Quest for Neurodegenerative Disease Treatment—Focusing on Alzheimer’s Disease Personalised Diets

  • Matei Palimariciuc,
  • Ioana-Miruna Balmus,
  • Bogdan Gireadă,
  • Alin Ciobica,
  • Roxana Chiriță,
  • Alin-Constantin Iordache,
  • Mihai Apostu and
  • Romeo Petru Dobrin

9 February 2023

Dementia represents a clinical syndrome characterised by progressive decline in memory, language, visuospatial and executive function, personality, and behaviour, causing loss of abilities to perform instrumental or essential activities of daily livi...

  • Article
  • Open Access
9 Citations
3,349 Views
19 Pages

Changes in the Expression Profile of Pyroptosis-Related Genes in Senescent Retinal Pigment Epithelial Cells after Lutein Treatment

  • Barbara Strzalka-Mrozik,
  • Marcel Madej,
  • Natalia Kurowska,
  • Celina Kruszniewska-Rajs,
  • Magdalena Kimsa-Dudek,
  • Jolanta Adamska and
  • Joanna Magdalena Gola

9 February 2023

Retinal pigment epithelium (RPE) is a specialized structure essential for proper vision, which is constantly exposed to oxidative damage. With aging, this damage accumulates within the RPE cells, causing various diseases, including age-related macula...

  • Article
  • Open Access
4 Citations
4,293 Views
17 Pages

Therapeutic Effects of Aloe saponaria against Ulcerative Colitis Induced by Dextran Sulfate Sodium

  • Do Yeong Kweon,
  • Hee Jin Song,
  • Ji Eun Kim,
  • You Jeong Jin,
  • Yu Jeong Roh,
  • Ayun Seol,
  • Ju Min Park,
  • Eun Suk Lee,
  • Won Sik Choi and
  • Dae Youn Hwang

9 February 2023

Aloe vera (A. vera) has been studied as a treatment option for ulcerative colitis (UC), but there is a lack of scientific evidence showing whether treatment with Aloe saponaria (A. saponaria) can also be beneficial. To investigate the therapeutic pot...

  • Communication
  • Open Access
1 Citations
3,385 Views
12 Pages

Proof-of-Concept Analysis of B Cell Receptor Repertoire in COVID-19 Patients Undergoing ECMO by Single-Cell V(D)J and Gene Expression Sequencing

  • Alessia Gallo,
  • Nicola Cuscino,
  • Claudia Carcione,
  • Rosalia Busà,
  • Pier Giulio Conaldi and
  • Matteo Bulati

9 February 2023

SARS-CoV-2, which causes COVID-19, has altered human activities all over the world and has become a global hazard to public health. Despite considerable advancements in pandemic containment techniques, in which vaccination played a key role, COVID-19...

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Curr. Issues Mol. Biol. - ISSN 1467-3045