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Article

Hepatic Gene Expression Changes in Rats Internally Exposed to Radioactive 56MnO2 Particles at Low Doses

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Department of Pathological Anatomy and Forensic Medicine, Semey Medical University, Semey 071400, Kazakhstan
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Department of Public Health, Semey Medical University, Semey 071400, Kazakhstan
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Department of Microbiology, Semey Medical University, Semey 071400, Kazakhstan
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National Medical Research Center of Radiology, Ministry of Health of Russian Federation, 249031 Obninsk, Russia
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The Center for Peace, Hiroshima University, Hiroshima 7300053, Japan
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Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 7340037, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Asita Elengoe
Curr. Issues Mol. Biol. 2021, 43(2), 758-766; https://doi.org/10.3390/cimb43020055
Received: 18 May 2021 / Revised: 12 July 2021 / Accepted: 19 July 2021 / Published: 22 July 2021
(This article belongs to the Section Bioinformatics and Systems Biology Section)
We have studied the biological effects of the internal exposure to radioactive manganese-56 dioxide (56MnO2), the major radioisotope dust found in soil after atomic bomb explosions. Our previous study of blood chemistry indicated a possible adverse effect of 56MnO2 on the liver. In the present study, we further examined the effects on the liver by determining changes in hepatic gene expressions. Male Wistar rats were exposed to 56MnO2 particles (three groups with the whole-body doses of 41, 90, and 100 mGy), stable MnO2 particles, or external 60Co γ-rays (2 Gy), and were examined together with the non-treated control group on postexposure day 3 and day 61. No histopathological changes were observed in the liver. The mRNA expression of a p53-related gene, the cyclin-dependent kinase inhibitor 1A, increased in 56MnO2 as well as in γ-ray irradiated groups on postexposure day 3 and day 61. The expression of a stress-responsive gene, nuclear factor κB, was also increased by 56MnO2 and γ-rays on postexposure day 3. However, the expression of cytokine genes (interleukin-6 or chemokine ligand 2) or fibrosis-related TGF-β/Smad genes (Tgfb1, Smad3, or Smad4) was not altered by the exposure. Our data demonstrated that the internal exposure to 56MnO2 particles at less than 0.1 Gy significantly affected the short-term gene expressions in the liver in a similar manner with 2 Gy of external γ-irradiation. These changes may be adaptive responses because no changes occurred in cytokine or TGF-β/Smad gene expressions. View Full-Text
Keywords: residual radiation; internal radiation exposure; hepatic gene expression; radiation-sensitive genes; radiation-induced liver damages residual radiation; internal radiation exposure; hepatic gene expression; radiation-sensitive genes; radiation-induced liver damages
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MDPI and ACS Style

Ruslanova, B.; Abishev, Z.; Chaizhunussova, N.; Shabdarbayeva, D.; Tokesheva, S.; Amantayeva, G.; Kairkhanova, Y.; Stepanenko, V.; Hoshi, M.; Fujimoto, N. Hepatic Gene Expression Changes in Rats Internally Exposed to Radioactive 56MnO2 Particles at Low Doses. Curr. Issues Mol. Biol. 2021, 43, 758-766. https://doi.org/10.3390/cimb43020055

AMA Style

Ruslanova B, Abishev Z, Chaizhunussova N, Shabdarbayeva D, Tokesheva S, Amantayeva G, Kairkhanova Y, Stepanenko V, Hoshi M, Fujimoto N. Hepatic Gene Expression Changes in Rats Internally Exposed to Radioactive 56MnO2 Particles at Low Doses. Current Issues in Molecular Biology. 2021; 43(2):758-766. https://doi.org/10.3390/cimb43020055

Chicago/Turabian Style

Ruslanova, Bakhyt, Zhaslan Abishev, Nailya Chaizhunussova, Dariya Shabdarbayeva, Sholpan Tokesheva, Gaukhar Amantayeva, Ynkar Kairkhanova, Valeriy Stepanenko, Masaharu Hoshi, and Nariaki Fujimoto. 2021. "Hepatic Gene Expression Changes in Rats Internally Exposed to Radioactive 56MnO2 Particles at Low Doses" Current Issues in Molecular Biology 43, no. 2: 758-766. https://doi.org/10.3390/cimb43020055

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