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Sensors, Volume 20, Issue 2 (January-2 2020) – 251 articles
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Cover Story (view full-size image) The planar Hall resistance (PHR) magnetic biosensor detects the magnetically labeled biomolecules [...] Read more. The planar Hall resistance (PHR) magnetic biosensor detects the magnetically labeled biomolecules or cells, immobilized on the sensor’s surface. Magnetic nanoparticles are used as a molecular tag, converting the biomolecular concentrations into the magnetic stray field, which can be detected by PHR magnetoresistive element as a change of its output voltage signal. In this work, the concentration of magnetic nanoparticles, immobilized on the surface of the sensor, has been successfully detected by the self-field technique, excluding the external magnetic field. In addition, the antibody–antigen sandwich model structure was used to detect β-amyloid, which is a well-known biomarker of Alzheimer’s disease. The developed biosensor, based on PHR magnetoresistive element working in 2f harmonics mode, can be considered a portable and lower-cost alternative to the existing biosensors for point-of-care diagnostics devices. View this paper