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Review

Biopolymer-Based Microcarriers for Three-Dimensional Cell Culture and Engineered Tissue Formation

by 1,†, 2,†, 2,* and 2,*
1
Hubei Key Laboratory of Purification and Application of Plant Anti-Cancer Active Ingredients, School of Chemistry and Life Sciences, Hubei University of Education, Wuhan 430205, China
2
Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan 430074, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(5), 1895; https://doi.org/10.3390/ijms21051895
Received: 7 February 2020 / Revised: 1 March 2020 / Accepted: 8 March 2020 / Published: 10 March 2020
The concept of three-dimensional (3D) cell culture has been proposed to maintain cellular morphology and function as in vivo. Among different approaches for 3D cell culture, microcarrier technology provides a promising tool for cell adhesion, proliferation, and cellular interactions in 3D space mimicking the in vivo microenvironment. In particular, microcarriers based on biopolymers have been widely investigated because of their superior biocompatibility and biodegradability. Moreover, through bottom-up assembly, microcarriers have opened a bright door for fabricating engineered tissues, which is one of the cutting-edge topics in tissue engineering and regeneration medicine. This review takes an in-depth look into the recent advancements of microcarriers based on biopolymers—especially polysaccharides such as chitosan, chitin, cellulose, hyaluronic acid, alginate, and laminarin—for 3D cell culture and the fabrication of engineered tissues based on them. The current limitations and potential strategies were also discussed to shed some light on future directions. View Full-Text
Keywords: biopolymer; polysaccharide; microcarrier; 3D cell culture; engineered tissue; bottom-up assembly biopolymer; polysaccharide; microcarrier; 3D cell culture; engineered tissue; bottom-up assembly
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MDPI and ACS Style

Huang, L.; Abdalla, A.M.E.; Xiao, L.; Yang, G. Biopolymer-Based Microcarriers for Three-Dimensional Cell Culture and Engineered Tissue Formation. Int. J. Mol. Sci. 2020, 21, 1895. https://doi.org/10.3390/ijms21051895

AMA Style

Huang L, Abdalla AME, Xiao L, Yang G. Biopolymer-Based Microcarriers for Three-Dimensional Cell Culture and Engineered Tissue Formation. International Journal of Molecular Sciences. 2020; 21(5):1895. https://doi.org/10.3390/ijms21051895

Chicago/Turabian Style

Huang, Lixia; Abdalla, Ahmed M.E.; Xiao, Lin; Yang, Guang. 2020. "Biopolymer-Based Microcarriers for Three-Dimensional Cell Culture and Engineered Tissue Formation" Int. J. Mol. Sci. 21, no. 5: 1895. https://doi.org/10.3390/ijms21051895

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