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Review

Cancer Stem Cell-Associated Pathways in the Metabolic Reprogramming of Breast Cancer

by 1,2 and 1,2,3,*
1
Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada
2
Ottawa Institute of Systems Biology, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada
3
Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(23), 9125; https://doi.org/10.3390/ijms21239125
Received: 6 October 2020 / Revised: 25 November 2020 / Accepted: 26 November 2020 / Published: 30 November 2020
(This article belongs to the Special Issue Breast Cancer: From Pathophysiology to Novel Therapeutic Approaches)
Metabolic reprogramming of cancer is now considered a hallmark of many malignant tumors, including breast cancer, which remains the most commonly diagnosed cancer in women all over the world. One of the main challenges for the effective treatment of breast cancer emanates from the existence of a subpopulation of tumor-initiating cells, known as cancer stem cells (CSCs). Over the years, several pathways involved in the regulation of CSCs have been identified and characterized. Recent research has also shown that CSCs are capable of adopting a metabolic flexibility to survive under various stressors, contributing to chemo-resistance, metastasis, and disease relapse. This review summarizes the links between the metabolic adaptations of breast cancer cells and CSC-associated pathways. Identification of the drivers capable of the metabolic rewiring in breast cancer cells and CSCs and the signaling pathways contributing to metabolic flexibility may lead to the development of effective therapeutic strategies. This review also covers the role of these metabolic adaptation in conferring drug resistance and metastasis in breast CSCs. View Full-Text
Keywords: breast cancer; cancer stem cells; metabolism; signaling pathways breast cancer; cancer stem cells; metabolism; signaling pathways
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MDPI and ACS Style

El-Sahli, S.; Wang, L. Cancer Stem Cell-Associated Pathways in the Metabolic Reprogramming of Breast Cancer. Int. J. Mol. Sci. 2020, 21, 9125. https://doi.org/10.3390/ijms21239125

AMA Style

El-Sahli S, Wang L. Cancer Stem Cell-Associated Pathways in the Metabolic Reprogramming of Breast Cancer. International Journal of Molecular Sciences. 2020; 21(23):9125. https://doi.org/10.3390/ijms21239125

Chicago/Turabian Style

El-Sahli, Sara, and Lisheng Wang. 2020. "Cancer Stem Cell-Associated Pathways in the Metabolic Reprogramming of Breast Cancer" International Journal of Molecular Sciences 21, no. 23: 9125. https://doi.org/10.3390/ijms21239125

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