Disease-Specific Expression of Conjunctiva Associated Lymphoid Tissue (CALT) in Mouse Models of Dry Eye Disease and Ocular Allergy
Abstract
1. Introduction
2. Results
2.1. Ocular Allergy and Dry Eye Disease Changes the Appearance of CALT in Mice
2.2. Antigen-Presenting Cells in CALT
2.3. Antigen-Presenting Cells Are Crucial for the Development of CALT
2.4. Antigen-Uptake and Presentation in CALT
3. Discussion
4. Methods
4.1. Animal Experiments
4.2. Immunohistochemistry
4.3. Flow Cytometry
4.4. Statistics
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
APC | Antigen-presenting cell |
CALT | Conjunctiva-associated lymphoid tissue |
CtB | Choleratoxin B |
EDE | Experimental Dry-Eye |
MALT | Mucosa-associated lymphoid tissue |
MHC | Major-histocompatibility complex |
MFI | Mean fluorescence intensity |
OSD | Ocular surface disease |
OVA | Ovalbumine |
PBS | Phosphate-buffered saline |
SRW | Short ragweed |
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Steven, P.; Schwab, S.; Kiesewetter, A.; Saban, D.R.; Stern, M.E.; Gehlsen, U. Disease-Specific Expression of Conjunctiva Associated Lymphoid Tissue (CALT) in Mouse Models of Dry Eye Disease and Ocular Allergy. Int. J. Mol. Sci. 2020, 21, 7514. https://doi.org/10.3390/ijms21207514
Steven P, Schwab S, Kiesewetter A, Saban DR, Stern ME, Gehlsen U. Disease-Specific Expression of Conjunctiva Associated Lymphoid Tissue (CALT) in Mouse Models of Dry Eye Disease and Ocular Allergy. International Journal of Molecular Sciences. 2020; 21(20):7514. https://doi.org/10.3390/ijms21207514
Chicago/Turabian StyleSteven, Philipp, Sebastian Schwab, Anne Kiesewetter, Daniel R. Saban, Michael E. Stern, and Uta Gehlsen. 2020. "Disease-Specific Expression of Conjunctiva Associated Lymphoid Tissue (CALT) in Mouse Models of Dry Eye Disease and Ocular Allergy" International Journal of Molecular Sciences 21, no. 20: 7514. https://doi.org/10.3390/ijms21207514
APA StyleSteven, P., Schwab, S., Kiesewetter, A., Saban, D. R., Stern, M. E., & Gehlsen, U. (2020). Disease-Specific Expression of Conjunctiva Associated Lymphoid Tissue (CALT) in Mouse Models of Dry Eye Disease and Ocular Allergy. International Journal of Molecular Sciences, 21(20), 7514. https://doi.org/10.3390/ijms21207514