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Open AccessArticle

Exceptionally Long-Lived Individuals (ELLI) Demonstrate Slower Aging Rate Calculated by DNA Methylation Clocks as Possible Modulators for Healthy Longevity

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Department of Human Biology, Faculty of Natural Sciences, University of Haifa, Haifa 3498838, Israel
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Faculty of Public Health, University of Haifa, Haifa 3498838, Israel
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Department of Geriatrics and Skilled Nursing, Laniado Medical Center, Netanya 4244916, Israel
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Ruth and Bruce Rappaport Faculty of Medicine, Technion–Israel Institute of Technology, Haifa 3200003, Israel
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Department of Geriatrics, Rambam Health Care Campus, Haifa 3109601, Israel
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Departments of Genetics and Medicine, Division of endocrinology, Institute for Aging Research and the Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(2), 615; https://doi.org/10.3390/ijms21020615
Received: 25 November 2019 / Revised: 14 January 2020 / Accepted: 15 January 2020 / Published: 17 January 2020
Exceptionally long-lived individuals (ELLI) who are the focus of many healthy longevity studies around the globe are now being studied in Israel. The Israeli Multi-Ethnic Centenarian Study (IMECS) cohort is utilized here for assessment of various DNA methylation clocks. Thorough phenotypic characterization and whole blood samples were obtained from ELLI, offspring of ELLI, and controls aged 53–87 with no familial exceptional longevity. DNA methylation was assessed using Illumina MethylationEPIC Beadchip and applied to DNAm age online tool for age and telomere length predictions. Relative telomere length was assessed using qPCR T/S (Telomere/Single copy gene) ratios. ELLI demonstrated juvenile performance in DNAm age clocks and overall methylation measurement, with preserved cognition and relative telomere length. Our findings suggest a favorable DNA methylation profile in ELLI enabling a slower rate of aging in those individuals in comparison to controls. It is possible that DNA methylation is a key modulator of the rate of aging and thus the ELLI DNAm profile promotes healthy longevity. View Full-Text
Keywords: healthy aging; DNA methylation; epigenetic clocks; telomere length; centenarians healthy aging; DNA methylation; epigenetic clocks; telomere length; centenarians
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Gutman, D.; Rivkin, E.; Fadida, A.; Sharvit, L.; Hermush, V.; Rubin, E.; Kirshner, D.; Sabin, I.; Dwolatzky, T.; Atzmon, G. Exceptionally Long-Lived Individuals (ELLI) Demonstrate Slower Aging Rate Calculated by DNA Methylation Clocks as Possible Modulators for Healthy Longevity. Int. J. Mol. Sci. 2020, 21, 615.

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