Immune Modulation of Platelet-Derived Mitochondria on Memory CD4+ T Cells in Humans
Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA
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Int. J. Mol. Sci. 2020, 21(17), 6295; https://doi.org/10.3390/ijms21176295
Received: 17 July 2020 / Revised: 25 August 2020 / Accepted: 28 August 2020 / Published: 31 August 2020
(This article belongs to the Special Issue Physiology of Platelets in Humans and Animals)
CD4+ T cells are one of the key immune cells contributing to the immunopathogenesis of type 1 diabetes (T1D). Previous studies have reported that platelet-derived mitochondria suppress the proliferation of peripheral blood mononuclear cells (PBMC). To further characterize the immune modulation of platelet-derived mitochondria, the purified CD4+ T cells were treated, respectively, with platelet-derived mitochondria. The data demonstrated that MitoTracker Deep Red-labeled platelet-derived mitochondria could directly target CD4+ T cells through C-X-C motif chemokine receptor 4 (CXCR4) and its ligand stromal cell-derived factor-1 (SDF-1), regulating the anti-CD3/CD28 bead-activated CD4+ T cells. The result was an up-regulation of Naïve and central memory (TCM) CD4+ T cells, the down-regulation of effector memory (TEM) CD4+ T cells, and modulations of cytokine productions and gene expressions. Thus, platelet-derived mitochondria have a translational potential as novel immune modulators to treat T1D and other autoimmune diseases.
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Keywords:
platelets; mitochondria; CD4+ T cells; immune modulation; central memory T cells; effector memory T cells; type 1 diabetes; autoimmune disease
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MDPI and ACS Style
Yu, H.; Hu, W.; Song, X.; Zhao, Y. Immune Modulation of Platelet-Derived Mitochondria on Memory CD4+ T Cells in Humans. Int. J. Mol. Sci. 2020, 21, 6295. https://doi.org/10.3390/ijms21176295
AMA Style
Yu H, Hu W, Song X, Zhao Y. Immune Modulation of Platelet-Derived Mitochondria on Memory CD4+ T Cells in Humans. International Journal of Molecular Sciences. 2020; 21(17):6295. https://doi.org/10.3390/ijms21176295
Chicago/Turabian StyleYu, Haibo; Hu, Wei; Song, Xiang; Zhao, Yong. 2020. "Immune Modulation of Platelet-Derived Mitochondria on Memory CD4+ T Cells in Humans" Int. J. Mol. Sci. 21, no. 17: 6295. https://doi.org/10.3390/ijms21176295
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