Immune Modulation of Platelet-Derived Mitochondria on Memory CD4+ T Cells in Humans
Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(17), 6295; https://doi.org/10.3390/ijms21176295
Received: 17 July 2020 / Revised: 25 August 2020 / Accepted: 28 August 2020 / Published: 31 August 2020
(This article belongs to the Special Issue Physiology of Platelets in Humans and Animals)
CD4+ T cells are one of the key immune cells contributing to the immunopathogenesis of type 1 diabetes (T1D). Previous studies have reported that platelet-derived mitochondria suppress the proliferation of peripheral blood mononuclear cells (PBMC). To further characterize the immune modulation of platelet-derived mitochondria, the purified CD4+ T cells were treated, respectively, with platelet-derived mitochondria. The data demonstrated that MitoTracker Deep Red-labeled platelet-derived mitochondria could directly target CD4+ T cells through C-X-C motif chemokine receptor 4 (CXCR4) and its ligand stromal cell-derived factor-1 (SDF-1), regulating the anti-CD3/CD28 bead-activated CD4+ T cells. The result was an up-regulation of Naïve and central memory (TCM) CD4+ T cells, the down-regulation of effector memory (TEM) CD4+ T cells, and modulations of cytokine productions and gene expressions. Thus, platelet-derived mitochondria have a translational potential as novel immune modulators to treat T1D and other autoimmune diseases.
View Full-Text
Keywords:
platelets; mitochondria; CD4+ T cells; immune modulation; central memory T cells; effector memory T cells; type 1 diabetes; autoimmune disease
▼
Show Figures
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Yu, H.; Hu, W.; Song, X.; Zhao, Y. Immune Modulation of Platelet-Derived Mitochondria on Memory CD4+ T Cells in Humans. Int. J. Mol. Sci. 2020, 21, 6295. https://doi.org/10.3390/ijms21176295
AMA Style
Yu H, Hu W, Song X, Zhao Y. Immune Modulation of Platelet-Derived Mitochondria on Memory CD4+ T Cells in Humans. International Journal of Molecular Sciences. 2020; 21(17):6295. https://doi.org/10.3390/ijms21176295
Chicago/Turabian StyleYu, Haibo; Hu, Wei; Song, Xiang; Zhao, Yong. 2020. "Immune Modulation of Platelet-Derived Mitochondria on Memory CD4+ T Cells in Humans" Int. J. Mol. Sci. 21, no. 17: 6295. https://doi.org/10.3390/ijms21176295
Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
Search more from Scilit