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Open AccessArticle

A Novel Hybrid Drug Delivery System for Treatment of Aortic Aneurysms

1
Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan
2
Graduate School of Health and Welfare, Yamaguchi Prefectural University, Yamaguchi 753-8502, Japan
3
Cardiovascular Research Institute, Kurume University, Kurume 830-0011, Japan
4
Graduate School of Medicine, Yamaguchi University, Ube 755-8611, Japan
5
Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo 156-8502, Japan
6
The Institute of Scientific and Industrial Research, Osaka University, Ibaraki 567-0047, Japan
7
Department of Applied Chemistry, Graduate School of Sciences and Technology for Innovation, Yamaguchi University, Ube 755-8611, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(15), 5538; https://doi.org/10.3390/ijms21155538
Received: 28 June 2020 / Revised: 29 July 2020 / Accepted: 31 July 2020 / Published: 2 August 2020
(This article belongs to the Special Issue Molecular Research On Abdominal Aortic Aneurysm)
Ongoing aortic wall degeneration and subsequent aneurysm exclusion failure are major concerns after an endovascular aneurysm repair with a stent-graft. An ideal solution would be a drug therapy that targets the aortic wall and inhibits wall degeneration. Here, we described a novel drug delivery system, which allowed repetitively charging a graft with therapeutic drugs and releasing them to the aortic wall in vivo. The system was composed of a targeted graft, which was labeled with a small target molecule, and the target-recognizing nanocarrier, which contained suitable drugs. We developed the targeted graft by decorating a biotinylated polyester graft with neutravidin. We created the target-recognizing nanocarrier by conjugating drug-containing liposomes with biotinylated bio-nanocapsules. We successfully demonstrated that the target-recognizing nanocarriers could bind to the targeted graft, both in vitro and in blood vessels of live mice. Moreover, the drug released from our drug delivery system reduced the expression of matrix metalloproteinase-9 in mouse aortas. Thus, this hybrid system represents a first step toward an adjuvant therapy that might improve the long-term outcome of endovascular aneurysm repair. View Full-Text
Keywords: drug delivery system; aortic aneurysm; endovascular aneurysm repair; bio-nanocapsule drug delivery system; aortic aneurysm; endovascular aneurysm repair; bio-nanocapsule
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MDPI and ACS Style

Yoshimura, K.; Aoki, H.; Teruyama, C.; Iijima, M.; Tsutsumi, H.; Kuroda, S.; Hamano, K. A Novel Hybrid Drug Delivery System for Treatment of Aortic Aneurysms. Int. J. Mol. Sci. 2020, 21, 5538. https://doi.org/10.3390/ijms21155538

AMA Style

Yoshimura K, Aoki H, Teruyama C, Iijima M, Tsutsumi H, Kuroda S, Hamano K. A Novel Hybrid Drug Delivery System for Treatment of Aortic Aneurysms. International Journal of Molecular Sciences. 2020; 21(15):5538. https://doi.org/10.3390/ijms21155538

Chicago/Turabian Style

Yoshimura, Koichi; Aoki, Hiroki; Teruyama, Chie; Iijima, Masumi; Tsutsumi, Hiromori; Kuroda, Shun’ichi; Hamano, Kimikazu. 2020. "A Novel Hybrid Drug Delivery System for Treatment of Aortic Aneurysms" Int. J. Mol. Sci. 21, no. 15: 5538. https://doi.org/10.3390/ijms21155538

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