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Non-Melanoma Skin Cancers: Biological and Clinical Features

1
Section of Medical Oncology, Department of Biomedical Sciences and Clinical Oncology (DIMO), University of Bari ‘Aldo Moro’, 70121 Bari, Italy
2
National Cancer Center, Tumori Institute Giovanni Paolo II, 70121 Bari, Italy
3
Section of Dermatology, Azienda Ospedaliero-Universitaria Policlinico di Bari, 70121 Bari, Italy
4
Section of Pathology, University of Bari ‘Aldo Moro’, 70121 Bari, Italy
5
Section of Plastic and Reconstructive Surgery, Department of Emergency and Organ Transplantation (DETO), University of Bari ‘Aldo Moro’, 70121 Bari, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(15), 5394; https://doi.org/10.3390/ijms21155394
Received: 8 July 2020 / Revised: 24 July 2020 / Accepted: 27 July 2020 / Published: 29 July 2020
(This article belongs to the Special Issue Skin Cancer: From Pathophysiology to Novel Therapeutic Approaches)
Non-melanoma skin cancers (NMSCs) include basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and Merkel cell carcinoma (MCC). These neoplasms are highly diverse in their clinical presentation, as well as in their biological evolution. While the deregulation of the Hedgehog pathway is commonly observed in BCC, SCC and MCC are characterized by a strikingly elevated mutational and neoantigen burden. As result of our improved understanding of the biology of non-melanoma skin cancers, innovative treatment options including inhibitors of the Hedgehog pathway and immunotherapeutic agents have been recently investigated against these malignancies, leading to their approval by regulatory authorities. Herein, we review the most relevant biological and clinical features of NMSC, focusing on innovative treatment approaches. View Full-Text
Keywords: skin cancer; basal cell carcinoma; squamous cell carcinoma; Merkel cell carcinoma; Hedgehog pathway; immunotherapy; anti-PD1 monoclonal antibodies skin cancer; basal cell carcinoma; squamous cell carcinoma; Merkel cell carcinoma; Hedgehog pathway; immunotherapy; anti-PD1 monoclonal antibodies
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MDPI and ACS Style

Cives, M.; Mannavola, F.; Lospalluti, L.; Sergi, M.C.; Cazzato, G.; Filoni, E.; Cavallo, F.; Giudice, G.; Stucci, L.S.; Porta, C.; Tucci, M. Non-Melanoma Skin Cancers: Biological and Clinical Features. Int. J. Mol. Sci. 2020, 21, 5394. https://doi.org/10.3390/ijms21155394

AMA Style

Cives M, Mannavola F, Lospalluti L, Sergi MC, Cazzato G, Filoni E, Cavallo F, Giudice G, Stucci LS, Porta C, Tucci M. Non-Melanoma Skin Cancers: Biological and Clinical Features. International Journal of Molecular Sciences. 2020; 21(15):5394. https://doi.org/10.3390/ijms21155394

Chicago/Turabian Style

Cives, Mauro; Mannavola, Francesco; Lospalluti, Lucia; Sergi, Maria C.; Cazzato, Gerardo; Filoni, Elisabetta; Cavallo, Federica; Giudice, Giuseppe; Stucci, Luigia S.; Porta, Camillo; Tucci, Marco. 2020. "Non-Melanoma Skin Cancers: Biological and Clinical Features" Int. J. Mol. Sci. 21, no. 15: 5394. https://doi.org/10.3390/ijms21155394

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