Optimization of Synthesis Parameters for Mesoporous Shell Formation on Magnetic Nanocores and Their Application as Nanocarriers for Docetaxel Cancer Drug
Abstract
:1. Introduction
2. Results and Discussion
2.1. Synthesis of Fe3O4 Nanoparticles
2.2. Dense Silica Coating of Magnetic Nanoparticles
2.2.1. Effect of Ethanol Concentration
2.2.2. Effect of Ammonia Concentration
2.3. Mesoporous Shell Formation on Silica Coated Magnetic Nanoparticles
2.3.1. Dense Silica Coating Step Parameters Influencing Mesoporous Shell Formation
2.3.1.1. Effect of Ethanol
2.3.1.2. Effect of Ammonia
2.3.2. Mesoporous Shell Formation Parameters
Effect of Surfactant
3. Experimental Section
3.1. Synthesis
3.1.1. Fe3O4 Synthesis
3.1.2. Dense Silica Coating
3.1.3. Construction of Mesoporous Silica Shell by Anionic Surfactant
3.2. Docetaxel Loading and Release Study
3.3. Characterization
4. Conclusions
Supplementary Information
ijms-14-11496-s001.pdfAcknowledgments
Conflict of Interest
References
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Sample code | NH4OH-1st a g/mL | EtOH g/mL | Surfactant mmol | HCl g/mL | Shell b 1st 2nd/nm | BET cm2/g | Vp c Cc/g | Rp d /nm | Drug EE e /% | |
---|---|---|---|---|---|---|---|---|---|---|
MCMSS1 | 0.03 | 0.87 | 5 | 0.16 | 10 | 43 | 411.09 | 0.373 | 3.6 | 27.54 |
MCMSS2 | 0.03 | 0.84 | 5 | 0.16 | 21 | 36 | 352.9 | 0.311 | 3.8 | - |
MCMSS3 | 0.03 | 0.8 | 5 | 0.16 | 25 | 27 | 319.81 | 0.292 | 3.6 | 33.81 |
MCMSS4 | 0.06 | 0.8 | 5 | 0.16 | 37 | 26 | 259.62 | 0.216 | 3.6 | - |
MCMSS5 | 0.016 | 0.8 | 5 | 0.16 | 14 | 44 | 389.32 | 0.328 | 3.8 | - |
MCMSS6 | 0.008 | 0.8 | 1 | 0.16 | 8 | 37 | 621.79 | 0.443 | 3.6 | 31.03 |
MCMSS7 | 0.008 | 0.8 | 5 | 0.16 | 8 | 50 | 386.94 | 0.338 | 3.8 | 25.67 |
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El-Toni, A.M.; Ibrahim, M.A.; Labis, J.P.; Khan, A.; Alhoshan, M. Optimization of Synthesis Parameters for Mesoporous Shell Formation on Magnetic Nanocores and Their Application as Nanocarriers for Docetaxel Cancer Drug. Int. J. Mol. Sci. 2013, 14, 11496-11509. https://doi.org/10.3390/ijms140611496
El-Toni AM, Ibrahim MA, Labis JP, Khan A, Alhoshan M. Optimization of Synthesis Parameters for Mesoporous Shell Formation on Magnetic Nanocores and Their Application as Nanocarriers for Docetaxel Cancer Drug. International Journal of Molecular Sciences. 2013; 14(6):11496-11509. https://doi.org/10.3390/ijms140611496
Chicago/Turabian StyleEl-Toni, Ahmed Mohamed, Mohamed Abbas Ibrahim, Joselito Puzon Labis, Aslam Khan, and Mansour Alhoshan. 2013. "Optimization of Synthesis Parameters for Mesoporous Shell Formation on Magnetic Nanocores and Their Application as Nanocarriers for Docetaxel Cancer Drug" International Journal of Molecular Sciences 14, no. 6: 11496-11509. https://doi.org/10.3390/ijms140611496