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Open AccessArticle

Magnetic Driven Nanocarriers for pH-Responsive Doxorubicin Release in Cancer Therapy

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CICECO-Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
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CICECO-Aveiro Institute of Materials, Department of Physics, University of Aveiro, 3810-193 Aveiro, Portugal
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Unit of Biochemistry, Department of Biomedicine, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal
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i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal
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Author to whom correspondence should be addressed.
Molecules 2020, 25(2), 333; https://doi.org/10.3390/molecules25020333 (registering DOI)
Received: 11 December 2019 / Revised: 10 January 2020 / Accepted: 10 January 2020 / Published: 14 January 2020
(This article belongs to the Special Issue Advances in Nanomaterials for Bioapplications and Water Treatment)
Doxorubicin is one of the most widely used anti-cancer drugs, but side effects and selectivity problems create a demand for alternative drug delivery systems. Herein we describe a hybrid magnetic nanomaterial as a pH-dependent doxorubicin release carrier. This nanocarrier comprises magnetic iron oxide cores with a diameter of 10 nm, enveloped in a hybrid material made of siliceous shells and ĸ-carrageenan. The hybrid shells possess high drug loading capacity and a favorable drug release profile, while the iron oxide cores allows easy manipulation via an external magnetic field. The pH responsiveness was assessed in phosphate buffers at pH levels equivalent to those of blood (pH 7.4) and tumor microenvironment (pH 4.2 and 5). The nanoparticles have a loading capacity of up to 12.3 wt.% and a release profile of 80% in 5 h at acidic pH versus 25% at blood pH. In vitro drug delivery tests on human breast cancer and non-cancer cellular cultures have shown that, compared to the free drug, the loaded nanocarriers have comparable antiproliferative effect but a less intense cytotoxic effect, especially in the non-cancer cell line. The results show a clear potential for these new hybrid nanomaterials as alternative drug carriers for doxorubicin. View Full-Text
Keywords: doxorubicin; magnetic nanoparticles; iron oxide; κ-carrageenan; drug carrier; pH-responsive doxorubicin; magnetic nanoparticles; iron oxide; κ-carrageenan; drug carrier; pH-responsive
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MDPI and ACS Style

Nogueira, J.; Soares, S.F.; Amorim, C.O.; Amaral, J.S.; Silva, C.; Martel, F.; Trindade, T.; Daniel-da-Silva, A.L. Magnetic Driven Nanocarriers for pH-Responsive Doxorubicin Release in Cancer Therapy. Molecules 2020, 25, 333.

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