Next Article in Journal
Synergistic Hypoglycemic Effects of Pumpkin Polysaccharides and Puerarin on Type II Diabetes Mellitus Mice
Next Article in Special Issue
Effect of Stereochemical Configuration on the Transport and Metabolism of Catechins from Green Tea across Caco-2 Monolayers
Previous Article in Journal
Magnetic Polyamide Nanocomposites for the Microextraction of Benzophenones from Water Samples
Review

Inhibitory Effects of (−)-Epigallocatechin-3-gallate on Esophageal Cancer

1
China-US (Henan) Hormel Cancer Institute, No. 127, Dongming Road, Zhengzhou 450008, Henan, China
2
Tea Research Institute, Zhejiang University, Hangzhou 310058, China
3
Ningbo Huangjinyun Tea Science and Technology Co. Ltd., Yuyao 315412, China
4
National Tea and Tea Product Quality Supervision and Inspection Center (Guizhou), Zunyi 563100, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Saverio Bettuzzi
Molecules 2019, 24(5), 954; https://doi.org/10.3390/molecules24050954
Received: 5 February 2019 / Revised: 24 February 2019 / Accepted: 4 March 2019 / Published: 8 March 2019
(This article belongs to the Special Issue Catechins in Human Health)
There is epidemiological evidence showing that drinking green tea can lower the risk of esophageal cancer (EC). The effect is mainly attributed to tea polyphenols and their most abundant component, (−)-epigallocatechin-3-gallate (EGCG). The possible mechanisms of tumorigenesis inhibition of EGCG include its suppressive effects on cancer cell proliferation, angiogenesis, DNA methylation, metastasis and oxidant stress. EGCG modulates multiple signal transduction and metabolic signaling pathways involving in EC. A synergistic effect was also observed when EGCG was used in combination with other treatment methods. View Full-Text
Keywords: tea polyphenols; anticancer; angiogenesis; DNA methylation; metastasis; oxidant stress tea polyphenols; anticancer; angiogenesis; DNA methylation; metastasis; oxidant stress
Show Figures

Graphical abstract

MDPI and ACS Style

Wang, L.-X.; Shi, Y.-L.; Zhang, L.-J.; Wang, K.-R.; Xiang, L.-P.; Cai, Z.-Y.; Lu, J.-L.; Ye, J.-H.; Liang, Y.-R.; Zheng, X.-Q. Inhibitory Effects of (−)-Epigallocatechin-3-gallate on Esophageal Cancer. Molecules 2019, 24, 954. https://doi.org/10.3390/molecules24050954

AMA Style

Wang L-X, Shi Y-L, Zhang L-J, Wang K-R, Xiang L-P, Cai Z-Y, Lu J-L, Ye J-H, Liang Y-R, Zheng X-Q. Inhibitory Effects of (−)-Epigallocatechin-3-gallate on Esophageal Cancer. Molecules. 2019; 24(5):954. https://doi.org/10.3390/molecules24050954

Chicago/Turabian Style

Wang, Liu-Xiang, Yun-Long Shi, Long-Jie Zhang, Kai-Rong Wang, Li-Ping Xiang, Zhuo-Yu Cai, Jian-Liang Lu, Jian-Hui Ye, Yue-Rong Liang, and Xin-Qiang Zheng. 2019. "Inhibitory Effects of (−)-Epigallocatechin-3-gallate on Esophageal Cancer" Molecules 24, no. 5: 954. https://doi.org/10.3390/molecules24050954

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop