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Synergistic Hypoglycemic Effects of Pumpkin Polysaccharides and Puerarin on Type II Diabetes Mellitus Mice

by Xue Chen 1,†, Lei Qian 2,3,†, Bujiang Wang 1, Zhijun Zhang 2,3, Han Liu 1, Yeni Zhang 1,* and Jinfu Liu 1,*
College of Food Science and Biotechnology, Tianjin Agricultural University, Tianjin 300384, China
Tianjin Research Institute of Forestry and Pomology, Tianjin Academy of Agricultural Sciences, Tianjin 300384, China
Key Laboratory of Storage of Agro-products, Ministry of Agriculture, Tianjin 300384, China
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2019, 24(5), 955;
Received: 30 November 2018 / Revised: 7 February 2019 / Accepted: 5 March 2019 / Published: 8 March 2019
To investigate the hypoglycemic effect and potential mechanism of pumpkin polysaccharides and puerarin on type II diabetes mellitus (T2DM) mice, mice were fed a high-fat diet and injected intraperitoneally with streptozotacin to induce T2DM. After eight weeks of drug administration, blood samples were withdrawn from tail veins of mice that had been fasted overnight. The results showed that both pumpkin polysaccharides and puerarin, as well as a pumpkin polysaccharides and puerarin combination, could ameliorate T2DM. The pumpkin polysaccharides and puerarin combination had a synergetic hypoglycemic effect on T2DM mice that was greater than the pumpkin polysaccharides’ or the puerarin’s hypoglycemic effect. Both the pumpkin polysaccharides and the puerarin were found to ameliorate the blood glucose tolerance and insulin resistance of T2DM mice. They showed lipid-lowering activity by reducing the total cholesterol, triglycerides, and low-density lipoprotein levels, and improving the high-density lipoprotein level. They had beneficial effects on the oxidative stress by decreasing the reactive oxygen species and malondialdehyde levels, and increasing the glutathione level and the superoxide dismutase activity. Furthermore, the nuclear factor E2 related factor 2 (Nrf2), heme oxygenase-1, and phosphoinositide-3-kinase (PI3K) levels were upregulated, and the Nrf2 and PI3K signalling pathways might be involved in the hypoglycemic mechanism. The combined administration of pumpkin polysaccharides and puerarin could synergistically ameliorate T2DM. View Full-Text
Keywords: type II diabetes mellitus; pumpkin polysaccharides; puerarin; mechanism type II diabetes mellitus; pumpkin polysaccharides; puerarin; mechanism
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MDPI and ACS Style

Chen, X.; Qian, L.; Wang, B.; Zhang, Z.; Liu, H.; Zhang, Y.; Liu, J. Synergistic Hypoglycemic Effects of Pumpkin Polysaccharides and Puerarin on Type II Diabetes Mellitus Mice. Molecules 2019, 24, 955.

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