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Molecules 2018, 23(9), 2254; https://doi.org/10.3390/molecules23092254

Protection against UVB-Induced Wrinkle Formation in SKH-1 Hairless Mice: Efficacy of Tricin Isolated from Enzyme-Treated Zizania latifolia Extract

1
BTC Corporation, Sangnok.gu, Ansan 15588, Korea
2
Institute of Natural Science, Keimyung University, Daegu 42601, Korea
3
Department of Applied Chemistry, Kumoh National Institute of Technology, Gumi 39177, Korea
4
Department of Food Science and Technology, Keimyung University, Daegu 42601, Korea
*
Author to whom correspondence should be addressed.
Received: 22 August 2018 / Revised: 1 September 2018 / Accepted: 3 September 2018 / Published: 4 September 2018
(This article belongs to the Section Natural Products Chemistry)
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Abstract

Tricin, a flavone found mainly in rice bran and sugarcane, has various beneficial effects. It has proven to be a clinically safe and selective potent inhibitor of different cancer cell lines. In this study, we evaluated the efficacy of enzyme-treated Zizania latifolia (ETZL) and its major active compound tricin on skin photoaging in SKH-1 hairless mice. Tricin (0.3 mg/kg) and ETZL (50, 150, and 300 mg/kg) were orally administrated to mice for 14 weeks; no cytotoxicity was observed during the entire experimental period. After UVB exposure, we observed significant increases in keratinization, coarse wrinkles, loss of moisture, thickened epidermis, and collagen fiber degradation in the dorsal skin. These features of photoaging were significantly suppressed after oral administration of tricin or ETZL. In addition, the protein expression of collagen effectively increased in ETZL (150 and 300 mg/kg)-treated mice, while the increased metalloproteinase (MMP)-1 and MMP-3 expressions were reduced after exposure to tricin or ETZL, although the effects were not dose-dependent. These data indicate that ETZL may be effective for attenuation of UVB-induced skin damage and photoaging in hairless mice, possibly by inhibiting MMPs expression. View Full-Text
Keywords: MMPs; skin aging; tricin; collagen; Zizania latifolia MMPs; skin aging; tricin; collagen; Zizania latifolia
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Moon, J.-M.; Park, S.-H.; Jhee, K.-H.; Yang, S.-A. Protection against UVB-Induced Wrinkle Formation in SKH-1 Hairless Mice: Efficacy of Tricin Isolated from Enzyme-Treated Zizania latifolia Extract. Molecules 2018, 23, 2254.

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