Next Article in Journal
Gold Catalyzed Multicomponent Reactions beyond A3 Coupling
Previous Article in Journal
Polypyridyl Zinc(II)-Indomethacin Complexes with Potent Anti-Breast Cancer Stem Cell Activity
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessArticle
Molecules 2018, 23(9), 2254;

Protection against UVB-Induced Wrinkle Formation in SKH-1 Hairless Mice: Efficacy of Tricin Isolated from Enzyme-Treated Zizania latifolia Extract

BTC Corporation,, Ansan 15588, Korea
Institute of Natural Science, Keimyung University, Daegu 42601, Korea
Department of Applied Chemistry, Kumoh National Institute of Technology, Gumi 39177, Korea
Department of Food Science and Technology, Keimyung University, Daegu 42601, Korea
Author to whom correspondence should be addressed.
Received: 22 August 2018 / Revised: 1 September 2018 / Accepted: 3 September 2018 / Published: 4 September 2018
(This article belongs to the Section Natural Products Chemistry)
Full-Text   |   PDF [1968 KB, uploaded 4 September 2018]   |  


Tricin, a flavone found mainly in rice bran and sugarcane, has various beneficial effects. It has proven to be a clinically safe and selective potent inhibitor of different cancer cell lines. In this study, we evaluated the efficacy of enzyme-treated Zizania latifolia (ETZL) and its major active compound tricin on skin photoaging in SKH-1 hairless mice. Tricin (0.3 mg/kg) and ETZL (50, 150, and 300 mg/kg) were orally administrated to mice for 14 weeks; no cytotoxicity was observed during the entire experimental period. After UVB exposure, we observed significant increases in keratinization, coarse wrinkles, loss of moisture, thickened epidermis, and collagen fiber degradation in the dorsal skin. These features of photoaging were significantly suppressed after oral administration of tricin or ETZL. In addition, the protein expression of collagen effectively increased in ETZL (150 and 300 mg/kg)-treated mice, while the increased metalloproteinase (MMP)-1 and MMP-3 expressions were reduced after exposure to tricin or ETZL, although the effects were not dose-dependent. These data indicate that ETZL may be effective for attenuation of UVB-induced skin damage and photoaging in hairless mice, possibly by inhibiting MMPs expression. View Full-Text
Keywords: MMPs; skin aging; tricin; collagen; Zizania latifolia MMPs; skin aging; tricin; collagen; Zizania latifolia

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Moon, J.-M.; Park, S.-H.; Jhee, K.-H.; Yang, S.-A. Protection against UVB-Induced Wrinkle Formation in SKH-1 Hairless Mice: Efficacy of Tricin Isolated from Enzyme-Treated Zizania latifolia Extract. Molecules 2018, 23, 2254.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top