Gold Catalyzed Multicomponent Reactions beyond A3 Coupling
Abstract
:1. Introduction
2. Gold-Catalyzed Multicomponent Reactions
2.1. Multicomponent Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones. A Biginelli Approach
2.2. Multicomponent Synthesis of 1,4-Dihydropyridines (1,4-DHPs)
2.3. Multicomponent Synthesis of Pyridines
2.4. Multicomponent Synthesis of Oxazoles
2.5. Multicomponent Synthesis of β-Alkoxy Ketones
2.6. Multicomponent Oxidative Oxyarylation of Alkenes
2.7. Multicomponent Synthesis of Thiazoloquinolines
2.8. Multicomponent Synthesis of Spirocycles
2.9. Multicomponent Synthesis of Butenolides
3. Conclusions
Author Contributions
Funding
Conflicts of Interest
References and Note
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Entry | R | Yield (%) | Entry | R | Yield (%) |
---|---|---|---|---|---|
1 | Me | 79 | 7 | 85 | |
2 | Et | 85 | 8 | 88 d.r. 1:1 | |
3 | iPr | 90 | 9 | Me(CO)- | 62 |
4 | (Me)3CCH2 | 91 | 10 | Et(CO)- | 69 |
5 | tBu | 33 | 11 | iPr(CO)- | 50 |
6 | 85 | 12 | Ph(CO)- | 48 |
Entry | R | Yield (%) | Entry | R | Yield (%) |
---|---|---|---|---|---|
1 | 4-Me | 88 | 7 | 4-MeO2C | 83 |
2 | 4-Br | 90 | 8 | 4-H(CO) | 82 |
3 | 3-F | 79 | 9 | 3,5-bis-CF3 | 77 |
Entry | R1 | R2 | Yield (%) | ||
---|---|---|---|---|---|
1 | 4-Br | 69 | |||
2 | Me | 2-CO2Me | 78 | ||
3 | Me(CO) | 4-Br | 51 | ||
4 | n = 5 | 4-Br | 76 | ||
5 | n = 5 | (Me)3CCH2 | 4-Br | 73 | |
6 | n = 9 | (Me)3CCH2 | H | 66 | |
7 | n = 5 | Me(CO) | 4-Br | 53 |
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Visbal, R.; Graus, S.; Herrera, R.P.; Gimeno, M.C. Gold Catalyzed Multicomponent Reactions beyond A3 Coupling. Molecules 2018, 23, 2255. https://doi.org/10.3390/molecules23092255
Visbal R, Graus S, Herrera RP, Gimeno MC. Gold Catalyzed Multicomponent Reactions beyond A3 Coupling. Molecules. 2018; 23(9):2255. https://doi.org/10.3390/molecules23092255
Chicago/Turabian StyleVisbal, Renso, Sara Graus, Raquel P. Herrera, and M. Concepción Gimeno. 2018. "Gold Catalyzed Multicomponent Reactions beyond A3 Coupling" Molecules 23, no. 9: 2255. https://doi.org/10.3390/molecules23092255