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MicroRNA Transcriptomes Relate Intermuscular Adipose Tissue to Metabolic Risk
Institute of Animal Genetics & Breeding, College of Animal Science & Technology, Sichuan Agricultural University, Ya'an 625014, China
College of Life and Basic Sciences, Sichuan Agricultural University, Ya'an 625014, China
Chongqing Academy of Animal Science, Chongqing 402460, China
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 20 March 2013; in revised form: 15 April 2013 / Accepted: 17 April 2013 / Published: 22 April 2013
Abstract: Intermuscular adipose tissue is located between the muscle fiber bundles in skeletal muscles, and has similar metabolic features to visceral adipose tissue, which has been found to be related to a number of obesity-related diseases. Although various miRNAs are known to play crucial roles in adipose deposition and adipogenesis, the microRNA transcriptome of intermuscular adipose tissue has not, until now, been studied. Here, we sequenced the miRNA transcriptomes of porcine intermuscular adipose tissue by small RNA-sequencing and compared it to a representative subcutaneous adipose tissue. We found that the inflammation- and diabetes-related miRNAs were significantly enriched in the intermuscular rather than in the subcutaneous adipose tissue. A functional enrichment analysis of the genes predicted to be targeted by the enriched miRNAs also indicated that intermuscular adipose tissue was associated mainly with immune and inflammation responses. Our results suggest that the intermuscular adipose tissue should be recognized as a potential metabolic risk factor of obesity.
Keywords: intermuscular adipose tissue (IMAT); metabolic risk; miRNA; pig; immune response; inflammation response; obesity; transcriptome
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Ma, J.; Yu, S.; Wang, F.; Bai, L.; Xiao, J.; Jiang, Y.; Chen, L.; Wang, J.; Jiang, A.; Li, M.; Li, X. MicroRNA Transcriptomes Relate Intermuscular Adipose Tissue to Metabolic Risk. Int. J. Mol. Sci. 2013, 14, 8611-8624.
Ma J, Yu S, Wang F, Bai L, Xiao J, Jiang Y, Chen L, Wang J, Jiang A, Li M, Li X. MicroRNA Transcriptomes Relate Intermuscular Adipose Tissue to Metabolic Risk. International Journal of Molecular Sciences. 2013; 14(4):8611-8624.
Ma, Jideng; Yu, Shuzhen; Wang, Fengjiao; Bai, Lin; Xiao, Jian; Jiang, Yanzhi; Chen, Lei; Wang, Jinyong; Jiang, Anan; Li, Mingzhou; Li, Xuewei. 2013. "MicroRNA Transcriptomes Relate Intermuscular Adipose Tissue to Metabolic Risk." Int. J. Mol. Sci. 14, no. 4: 8611-8624.