Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Int. J. Mol. Sci. 2013, 14(8), 16226-16239; doi:10.3390/ijms140816226
Article

Involvement of miR-20a in Promoting Gastric Cancer Progression by Targeting Early Growth Response 2 (EGR2)

,
,
,
,
, *  and *
Received: 5 June 2013; in revised form: 18 July 2013 / Accepted: 18 July 2013 / Published: 6 August 2013
(This article belongs to the Special Issue Regulation by non-coding RNAs)
View Full-Text   |   Download PDF [329 KB, uploaded 19 June 2014]
Abstract: Gastric cancer (GC) is one of the most common cancers, with high incidences in East Asia. microRNAs (miRNAs) play essential roles in the carcinogenesis of GC. miR-20a was elevated in GC, while the potential function of miR-20a was poorly understood. miR-20a expression was examined in GC tissues and cell lines. The effects of miR-20a on the growth, migration, invasion, and chemoresistance of GC cells were examined. Luciferase reporter assay and Western blot were used to screen the target of miR-20a. miR-20a was increased in GC tissues and cell lines. miR-20a promoted the growth, migration and invasion of GC cells, enhanced the chemoresistance of GC cells to cisplatin and docetaxel. Luciferase activity and Western blot confirmed that miR-20a negatively regulated EGR2 expression. Overexpression of EGR2 significantly attenuated the oncogenic effect of miR-20a. miR-20a was involved in the carcinogenesis of GC through modulation of the EGR2 signaling pathway.
Keywords: gastric cancer; miR-20a; early growth response 2; carcinogenesis; chemoresistance gastric cancer; miR-20a; early growth response 2; carcinogenesis; chemoresistance
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Li, X.; Zhang, Z.; Yu, M.; Li, L.; Du, G.; Xiao, W.; Yang, H. Involvement of miR-20a in Promoting Gastric Cancer Progression by Targeting Early Growth Response 2 (EGR2). Int. J. Mol. Sci. 2013, 14, 16226-16239.

AMA Style

Li X, Zhang Z, Yu M, Li L, Du G, Xiao W, Yang H. Involvement of miR-20a in Promoting Gastric Cancer Progression by Targeting Early Growth Response 2 (EGR2). International Journal of Molecular Sciences. 2013; 14(8):16226-16239.

Chicago/Turabian Style

Li, Xiangsheng; Zhang, Zhichao; Yu, Ming; Li, Liqi; Du, Guangsheng; Xiao, Weidong; Yang, Hua. 2013. "Involvement of miR-20a in Promoting Gastric Cancer Progression by Targeting Early Growth Response 2 (EGR2)." Int. J. Mol. Sci. 14, no. 8: 16226-16239.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert