Int. J. Mol. Sci. 2013, 14(7), 14374-14394; doi:10.3390/ijms140714374
Review

Micromanaging Abdominal Aortic Aneurysms

1 Department of Medicine, Karolinska Institute, Stockholm SE-17176, Sweden 2 Division of Cardiovascular Medicine, Stanford University, Stanford, CA 94305-5406, USA These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 26 April 2013; in revised form: 25 June 2013 / Accepted: 26 June 2013 / Published: 11 July 2013
(This article belongs to the Special Issue Regulation by non-coding RNAs)
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Abstract: The contribution of abdominal aortic aneurysm (AAA) disease to human morbidity and mortality has increased in the aging, industrialized world. In response, extraordinary efforts have been launched to determine the molecular and pathophysiological characteristics of the diseased aorta. This work aims to develop novel diagnostic and therapeutic strategies to limit AAA expansion and, ultimately, rupture. Contributions from multiple research groups have uncovered a complex transcriptional and post-transcriptional regulatory milieu, which is believed to be essential for maintaining aortic vascular homeostasis. Recently, novel small noncoding RNAs, called microRNAs, have been identified as important transcriptional and post-transcriptional inhibitors of gene expression. MicroRNAs are thought to “fine tune” the translational output of their target messenger RNAs (mRNAs) by promoting mRNA degradation or inhibiting translation. With the discovery that microRNAs act as powerful regulators in the context of a wide variety of diseases, it is only logical that microRNAs be thoroughly explored as potential therapeutic entities. This current review summarizes interesting findings regarding the intriguing roles and benefits of microRNA expression modulation during AAA initiation and propagation. These studies utilize disease-relevant murine models, as well as human tissue from patients undergoing surgical aortic aneurysm repair. Furthermore, we critically examine future therapeutic strategies with regard to their clinical and translational feasibility.
Keywords: microRNA; aortic aneurysm; fibrosis; vascular smooth muscle cells; inflammation; biomarker

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MDPI and ACS Style

Maegdefessel, L.; Spin, J.M.; Adam, M.; Raaz, U.; Toh, R.; Nakagami, F.; Tsao, P.S. Micromanaging Abdominal Aortic Aneurysms. Int. J. Mol. Sci. 2013, 14, 14374-14394.

AMA Style

Maegdefessel L, Spin JM, Adam M, Raaz U, Toh R, Nakagami F, Tsao PS. Micromanaging Abdominal Aortic Aneurysms. International Journal of Molecular Sciences. 2013; 14(7):14374-14394.

Chicago/Turabian Style

Maegdefessel, Lars; Spin, Joshua M.; Adam, Matti; Raaz, Uwe; Toh, Ryuji; Nakagami, Futoshi; Tsao, Philip S. 2013. "Micromanaging Abdominal Aortic Aneurysms." Int. J. Mol. Sci. 14, no. 7: 14374-14394.

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