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An Emerging Role for Long Non-Coding RNA Dysregulation in Neurological Disorders
Department of Pathophysiology and Transplantation, University of Milan, "Dino Ferrari" Center, IRCCS Cà Granda Foundation Ospedale Maggiore Policlinico, Via F.Sforza 35, Milan 20122, Italy
* Author to whom correspondence should be addressed.
Received: 14 June 2013; in revised form: 18 September 2013 / Accepted: 25 September 2013 / Published: 14 October 2013
Abstract: A novel class of transcripts, long non coding RNAs (lncRNAs), has recently emerged as key players in several biological processes, including dosage compensation, genomic imprinting, chromatin regulation, embryonic development and segmentation, stem cell pluripotency, cell fate determination and potentially many other biological processes, which still are to be elucidated. LncRNAs are pervasively transcribed in the genome and several lines of evidence correlate dysregulation of different lncRNAs to human diseases including neurological disorders. Although their mechanisms of action are yet to be fully elucidated, evidence suggests lncRNA contributions to the pathogenesis of a number of diseases. In this review, the current state of knowledge linking lncRNAs to different neurological disorders is discussed and potential future directions are considered.
Keywords: lncRNA; RNA; neurodegenerative diseases; epigenetics
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Fenoglio, C.; Ridolfi, E.; Galimberti, D.; Scarpini, E. An Emerging Role for Long Non-Coding RNA Dysregulation in Neurological Disorders. Int. J. Mol. Sci. 2013, 14, 20427-20442.
Fenoglio C, Ridolfi E, Galimberti D, Scarpini E. An Emerging Role for Long Non-Coding RNA Dysregulation in Neurological Disorders. International Journal of Molecular Sciences. 2013; 14(10):20427-20442.
Fenoglio, Chiara; Ridolfi, Elisa; Galimberti, Daniela; Scarpini, Elio. 2013. "An Emerging Role for Long Non-Coding RNA Dysregulation in Neurological Disorders." Int. J. Mol. Sci. 14, no. 10: 20427-20442.