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Non-Coding RNAs and Cancer
Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 5 July 2013; in revised form: 1 August 2013 / Accepted: 8 August 2013 / Published: 19 August 2013
Abstract: The discovery of the biological relevance of non-coding RNA (ncRNAs) molecules represents one of the most significant advances in contemporary molecular biology. Expression profiling of human tumors, based on the expression of miRNAs and other short or long ncRNAs, has identified signatures associated with diagnosis, staging, progression, prognosis, and response to treatment. In this review we will discuss the recent remarkable advancement in the understanding the biological functions of human ncRNAs in cancer, the mechanisms of expression and the therapeutic potential.
Keywords: small non-coding RNAs; long non-coding RNAs; cancer
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Calore, F.; Lovat, F.; Garofalo, M. Non-Coding RNAs and Cancer. Int. J. Mol. Sci. 2013, 14, 17085-17110.
Calore F, Lovat F, Garofalo M. Non-Coding RNAs and Cancer. International Journal of Molecular Sciences. 2013; 14(8):17085-17110.
Calore, Federica; Lovat, Francesca; Garofalo, Michela. 2013. "Non-Coding RNAs and Cancer." Int. J. Mol. Sci. 14, no. 8: 17085-17110.