Int. J. Mol. Sci. 2013, 14(8), 15681-15694; doi:10.3390/ijms140815681
Review

Impaired Pre-mRNA Processing and Altered Architecture of 3' Untranslated Regions Contribute to the Development of Human Disorders

Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Zluty kopec 7, Brno 656 53, Czech Republic
* Author to whom correspondence should be addressed.
Received: 31 May 2013; in revised form: 21 June 2013 / Accepted: 24 June 2013 / Published: 26 July 2013
(This article belongs to the Special Issue Regulation by non-coding RNAs)
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Abstract: The biological fate of each mRNA and consequently, the protein to be synthesised, is highly dependent on the nature of the 3' untranslated region. Despite its non-coding character, the 3' UTR may affect the final mRNA stability, the localisation, the export from the nucleus and the translation efficiency. The conserved regulatory sequences within 3' UTRs and the specific elements binding to them enable gene expression control at the posttranscriptional level and all these processes reflect the actual state of the cell including proliferation, differentiation, cellular stress or tumourigenesis. Through this article, we briefly outline how the alterations in the establishment and final architecture of 3' UTRs may contribute to the development of various disorders in humans.
Keywords: 3' UTR; trinucleotide repeat expansion; polymorphism; mutation; cancer

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MDPI and ACS Style

Michalova, E.; Vojtesek, B.; Hrstka, R. Impaired Pre-mRNA Processing and Altered Architecture of 3' Untranslated Regions Contribute to the Development of Human Disorders. Int. J. Mol. Sci. 2013, 14, 15681-15694.

AMA Style

Michalova E, Vojtesek B, Hrstka R. Impaired Pre-mRNA Processing and Altered Architecture of 3' Untranslated Regions Contribute to the Development of Human Disorders. International Journal of Molecular Sciences. 2013; 14(8):15681-15694.

Chicago/Turabian Style

Michalova, Eva; Vojtesek, Borivoj; Hrstka, Roman. 2013. "Impaired Pre-mRNA Processing and Altered Architecture of 3' Untranslated Regions Contribute to the Development of Human Disorders." Int. J. Mol. Sci. 14, no. 8: 15681-15694.

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