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Int. J. Mol. Sci. 2013, 14(10), 19681-19704; doi:10.3390/ijms141019681
Review

Non-Coding RNAs in Muscle Dystrophies

1
, 1,2,*  and 3,*
Received: 5 August 2013; in revised form: 5 September 2013 / Accepted: 9 September 2013 / Published: 30 September 2013
(This article belongs to the Special Issue Regulation by non-coding RNAs)
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Abstract: ncRNAs are the most recently identified class of regulatory RNAs with vital functions in gene expression regulation and cell development. Among the variety of roles they play, their involvement in human diseases has opened new avenues of research towards the discovery and development of novel therapeutic approaches. Important data come from the field of hereditary muscle dystrophies, like Duchenne muscle dystrophy and Myotonic dystrophies, rare diseases affecting 1 in 7000–15,000 newborns and is characterized by severe to mild muscle weakness associated with cardiac involvement. Novel therapeutic approaches are now ongoing for these diseases, also based on splicing modulation. In this review we provide an overview about ncRNAs and their behavior in muscular dystrophy and explore their links with diagnosis, prognosis and treatments, highlighting the role of regulatory RNAs in these pathologies.
Keywords: microRNAs (miRNAs); long non-coding RNAs (lncRNAs); Duchenne muscular dystrophy (DMD); Becker muscular dystrophy (BMD); Myotonic dystrophies (DM1 and DM2); Facioscapulohumeral dystrophy (FSHD) microRNAs (miRNAs); long non-coding RNAs (lncRNAs); Duchenne muscular dystrophy (DMD); Becker muscular dystrophy (BMD); Myotonic dystrophies (DM1 and DM2); Facioscapulohumeral dystrophy (FSHD)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Erriquez, D.; Perini, G.; Ferlini, A. Non-Coding RNAs in Muscle Dystrophies. Int. J. Mol. Sci. 2013, 14, 19681-19704.

AMA Style

Erriquez D, Perini G, Ferlini A. Non-Coding RNAs in Muscle Dystrophies. International Journal of Molecular Sciences. 2013; 14(10):19681-19704.

Chicago/Turabian Style

Erriquez, Daniela; Perini, Giovanni; Ferlini, Alessandra. 2013. "Non-Coding RNAs in Muscle Dystrophies." Int. J. Mol. Sci. 14, no. 10: 19681-19704.



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