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Non-Coding RNAs in Muscle Dystrophies
Department of Pharmacy and Biotechnology, University of Bologna, Bologna 40126, Italy
Health Sciences and Technologies–Interdepartmental Center for Industrial Research, University of Bologna, Bologna 40064, Italy
Section of Microbiology and Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara 44100, Italy
* Authors to whom correspondence should be addressed.
Received: 5 August 2013; in revised form: 5 September 2013 / Accepted: 9 September 2013 / Published: 30 September 2013
Abstract: ncRNAs are the most recently identified class of regulatory RNAs with vital functions in gene expression regulation and cell development. Among the variety of roles they play, their involvement in human diseases has opened new avenues of research towards the discovery and development of novel therapeutic approaches. Important data come from the field of hereditary muscle dystrophies, like Duchenne muscle dystrophy and Myotonic dystrophies, rare diseases affecting 1 in 7000–15,000 newborns and is characterized by severe to mild muscle weakness associated with cardiac involvement. Novel therapeutic approaches are now ongoing for these diseases, also based on splicing modulation. In this review we provide an overview about ncRNAs and their behavior in muscular dystrophy and explore their links with diagnosis, prognosis and treatments, highlighting the role of regulatory RNAs in these pathologies.
Keywords: microRNAs (miRNAs); long non-coding RNAs (lncRNAs); Duchenne muscular dystrophy (DMD); Becker muscular dystrophy (BMD); Myotonic dystrophies (DM1 and DM2); Facioscapulohumeral dystrophy (FSHD)
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Erriquez, D.; Perini, G.; Ferlini, A. Non-Coding RNAs in Muscle Dystrophies. Int. J. Mol. Sci. 2013, 14, 19681-19704.
Erriquez D, Perini G, Ferlini A. Non-Coding RNAs in Muscle Dystrophies. International Journal of Molecular Sciences. 2013; 14(10):19681-19704.
Erriquez, Daniela; Perini, Giovanni; Ferlini, Alessandra. 2013. "Non-Coding RNAs in Muscle Dystrophies." Int. J. Mol. Sci. 14, no. 10: 19681-19704.