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Int. J. Mol. Sci. 2013, 14(8), 16280-16302; doi:10.3390/ijms140816280

Principles of miRNA-Target Regulation in Metazoan Models

Received: 3 June 2013 / Revised: 29 July 2013 / Accepted: 31 July 2013 / Published: 7 August 2013
(This article belongs to the Special Issue Regulation by non-coding RNAs)
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Abstract: MicroRNAs (miRs) are key post-transcriptional regulators that silence gene expression by direct base pairing to target sites of RNAs. They have a wide variety of tissue expression patterns and are differentially expressed during development and disease. Their activity and abundance is subject to various levels of control ranging from transcription and biogenesis to miR response elements on RNAs, target cellular levels and miR turnover. This review summarizes and discusses current knowledge on the regulation of miR activity and concludes with novel non-canonical functions that have recently emerged.
Keywords: miR; miR biogenesis; miR targets; miR turnover; isomiR; ceRNA miR; miR biogenesis; miR targets; miR turnover; isomiR; ceRNA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Doxakis, E. Principles of miRNA-Target Regulation in Metazoan Models. Int. J. Mol. Sci. 2013, 14, 16280-16302.

AMA Style

Doxakis E. Principles of miRNA-Target Regulation in Metazoan Models. International Journal of Molecular Sciences. 2013; 14(8):16280-16302.

Chicago/Turabian Style

Doxakis, Epaminondas. 2013. "Principles of miRNA-Target Regulation in Metazoan Models." Int. J. Mol. Sci. 14, no. 8: 16280-16302.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert