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Principles of miRNA-Target Regulation in Metazoan Models
Basic Neurosciences Division, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou 4, Athens 11527, Greece
Received: 3 June 2013; in revised form: 29 July 2013 / Accepted: 31 July 2013 / Published: 7 August 2013
Abstract: MicroRNAs (miRs) are key post-transcriptional regulators that silence gene expression by direct base pairing to target sites of RNAs. They have a wide variety of tissue expression patterns and are differentially expressed during development and disease. Their activity and abundance is subject to various levels of control ranging from transcription and biogenesis to miR response elements on RNAs, target cellular levels and miR turnover. This review summarizes and discusses current knowledge on the regulation of miR activity and concludes with novel non-canonical functions that have recently emerged.
Keywords: miR; miR biogenesis; miR targets; miR turnover; isomiR; ceRNA
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Doxakis, E. Principles of miRNA-Target Regulation in Metazoan Models. Int. J. Mol. Sci. 2013, 14, 16280-16302.
Doxakis E. Principles of miRNA-Target Regulation in Metazoan Models. International Journal of Molecular Sciences. 2013; 14(8):16280-16302.
Doxakis, Epaminondas. 2013. "Principles of miRNA-Target Regulation in Metazoan Models." Int. J. Mol. Sci. 14, no. 8: 16280-16302.