• Abstract
• Full-Text PDF [250 KB]
• Full-Text XML
• Article Versions Notes

• Article Statistics
• PubMed/Medline
• Google Scholar
• Order Reprints

• Cite this article
• Export to BibTeX
• Export to EndNote

• [+] on DOAJ
• Hauptman, N
• Glavač, D
• [+] on Google Scholar
• Hauptman, N
• Glavač, D
• [+] on PubMed
• Hauptman, N
• Glavač, D

•  CiteULike
•  Facebook
•  Mendeley
•  Twitter

This article is

• freely available
• re-usable

Int. J. Mol. Sci. 2013, 14(3), 4655-4669; doi:10.3390/ijms14034655

Review

Long Non-Coding RNA in Cancer

Nina Hauptman ^†  and Damjan Glavač ^†,*

Department of Molecular Genetics, Institute of Pathology, University of Ljubljana, SI-1000 Ljubljana, Slovenia ^† These authors contributed equally to this work.

* Author to whom correspondence should be addressed.

Received: 1 November 2012; in revised form: 3 January 2013 / Accepted: 31 January 2013 / Published: 26 February 2013

(This article belongs to the Special Issue Regulation by non-coding RNAs)

Download PDF Full-Text [250 KB, uploaded 26 February 2013 13:31 CET]

Abstract: Long non-coding RNAs (lncRNAs) are pervasively transcribed in the genome and are emerging as new players in tumorigenesis due to their various functions in transcriptional, posttranscriptional and epigenetic mechanisms of gene regulation. LncRNAs are deregulated in a number of cancers, demonstrating both oncogenic and tumor suppressive roles, thus suggesting their aberrant expression may be a substantial contributor in cancer development. In this review, we will summarize their emerging role in human cancer and discuss their perspectives in diagnostics as potential biomarkers.

Keywords: long non-coding RNA; cancer; oncogenic lncRNA; tumor suppressor lncRNA

Article Statistics

Cite This Article