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Int. J. Mol. Sci. 2013, 14(3), 4655-4669; doi:10.3390/ijms14034655
Review

Long Non-Coding RNA in Cancer

 and †,*
Received: 1 November 2012; in revised form: 3 January 2013 / Accepted: 31 January 2013 / Published: 26 February 2013
(This article belongs to the Special Issue Regulation by non-coding RNAs)
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Abstract: Long non-coding RNAs (lncRNAs) are pervasively transcribed in the genome and are emerging as new players in tumorigenesis due to their various functions in transcriptional, posttranscriptional and epigenetic mechanisms of gene regulation. LncRNAs are deregulated in a number of cancers, demonstrating both oncogenic and tumor suppressive roles, thus suggesting their aberrant expression may be a substantial contributor in cancer development. In this review, we will summarize their emerging role in human cancer and discuss their perspectives in diagnostics as potential biomarkers.
Keywords: long non-coding RNA; cancer; oncogenic lncRNA; tumor suppressor lncRNA long non-coding RNA; cancer; oncogenic lncRNA; tumor suppressor lncRNA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Hauptman, N.; Glavač, D. Long Non-Coding RNA in Cancer. Int. J. Mol. Sci. 2013, 14, 4655-4669.

AMA Style

Hauptman N, Glavač D. Long Non-Coding RNA in Cancer. International Journal of Molecular Sciences. 2013; 14(3):4655-4669.

Chicago/Turabian Style

Hauptman, Nina; Glavač, Damjan. 2013. "Long Non-Coding RNA in Cancer." Int. J. Mol. Sci. 14, no. 3: 4655-4669.



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