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Int. J. Mol. Sci. 2013, 14(4), 8179-8187; doi:10.3390/ijms14048179

Advances in the Techniques for the Prediction of microRNA Targets

, 3,†
, 4
, 5
, 6,*  and 2,*
Received: 7 January 2013 / Revised: 1 April 2013 / Accepted: 2 April 2013 / Published: 15 April 2013
(This article belongs to the Special Issue "Regulation by non-coding RNAs (special issue))
View Full-Text   |   Download PDF [155 KB, uploaded 19 June 2014]
Abstract: MicroRNAs (miRNAs) are small, non-coding, endogenous RNA molecules that play important roles in a variety of normal and diseased biological processes by post-transcriptionally regulating the expression of target genes. They can bind to target messenger RNA (mRNA) transcripts of protein-coding genes and negatively control their translation or cause mRNA degradation. miRNAs have been found to actively regulate a variety of cellular processes, including cell proliferation, death, and metabolism. Therefore, their study is crucial for the better understanding of cellular functions in eukaryotes. To better understand the mechanisms of miRNA: mRNA interaction and their cellular functions, it is important to identify the miRNA targets accurately. In this paper, we provide a brief review for the advances in the animal miRNA target prediction methods and available resources to facilitate further study of miRNAs and their functions.
Keywords: prediction; microRNA; feature selection prediction; microRNA; feature selection
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zheng, H.; Fu, R.; Wang, J.-T.; Liu, Q.; Chen, H.; Jiang, S.-W. Advances in the Techniques for the Prediction of microRNA Targets. Int. J. Mol. Sci. 2013, 14, 8179-8187.

AMA Style

Zheng H, Fu R, Wang J-T, Liu Q, Chen H, Jiang S-W. Advances in the Techniques for the Prediction of microRNA Targets. International Journal of Molecular Sciences. 2013; 14(4):8179-8187.

Chicago/Turabian Style

Zheng, Hao; Fu, Rongguo; Wang, Jin-Tao; Liu, Qinyou; Chen, Haibin; Jiang, Shi-Wen. 2013. "Advances in the Techniques for the Prediction of microRNA Targets." Int. J. Mol. Sci. 14, no. 4: 8179-8187.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert