Int. J. Mol. Sci. 2013, 14(5), 9487-9496; doi:10.3390/ijms14059487

The Role of microRNA in Gastric Malignancy

1 Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan 2 Division of Gastroenterology, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo 152-8902, Japan
* Author to whom correspondence should be addressed.
Received: 27 March 2013; in revised form: 19 April 2013 / Accepted: 25 April 2013 / Published: 29 April 2013
(This article belongs to the Special Issue Regulation by non-coding RNAs)
PDF Full-text Download PDF Full-Text [421 KB, uploaded 29 April 2013 11:08 CEST]
Abstract: Helicobacter pylori (H. pylori) infection is the main cause of gastritis, gastro-duodenal ulcer, and gastric cancer. MicroRNAs (miRNAs) are small noncoding RNAs that function as endogenous silencers of numerous target genes. Many miRNA genes are expressed in a tissue-specific manner and play important roles in cell proliferation, apoptosis, and differentiation. Recent discoveries have shed new light on the involvement of miRNAs in gastric malignancy. However, at the same time, several miRNAs have been associated with opposing events, leading to reduced inflammation, inhibition of malignancy, and increased apoptosis of transformed cells. The regulation of miRNA expression could be a novel strategy in the chemoprevention of human gastric malignancy. In this article, the biological importance of miRNAs in gastric malignancy is summarized.
Keywords: microRNA; Helicobacter pylori; gastric cancer

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Nishizawa, T.; Suzuki, H. The Role of microRNA in Gastric Malignancy. Int. J. Mol. Sci. 2013, 14, 9487-9496.

AMA Style

Nishizawa T, Suzuki H. The Role of microRNA in Gastric Malignancy. International Journal of Molecular Sciences. 2013; 14(5):9487-9496.

Chicago/Turabian Style

Nishizawa, Toshihiro; Suzuki, Hidekazu. 2013. "The Role of microRNA in Gastric Malignancy." Int. J. Mol. Sci. 14, no. 5: 9487-9496.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert