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Int. J. Mol. Sci. 2013, 14(8), 15386-15422; doi:10.3390/ijms140815386
Review

Long Non-Coding RNAs in Haematological Malignancies

1
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1,2
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3,*
Received: 31 May 2013 / Revised: 28 June 2013 / Accepted: 9 July 2013 / Published: 24 July 2013
(This article belongs to the Special Issue Regulation by non-coding RNAs 2013)
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Abstract

Long non-coding RNAs (lncRNAs) are functional RNAs longer than 200 nucleotides in length. LncRNAs are as diverse as mRNAs and they normally share the same biosynthetic machinery based on RNA polymerase II, splicing and polyadenylation. However, lncRNAs have low coding potential. Compared to mRNAs, lncRNAs are preferentially nuclear, more tissue specific and expressed at lower levels. Most of the lncRNAs described to date modulate the expression of specific genes by guiding chromatin remodelling factors; inducing chromosomal loopings; affecting transcription, splicing, translation or mRNA stability; or serving as scaffolds for the organization of cellular structures. They can function in cis, cotranscriptionally, or in trans, acting as decoys, scaffolds or guides. These functions seem essential to allow cell differentiation and growth. In fact, many lncRNAs have been shown to exert oncogenic or tumor suppressor properties in several cancers including haematological malignancies. In this review, we summarize what is known about lncRNAs, the mechanisms for their regulation in cancer and their role in leukemogenesis, lymphomagenesis and hematopoiesis. Furthermore, we discuss the potential of lncRNAs in diagnosis, prognosis and therapy in cancer, with special attention to haematological malignancies.
Keywords: lncRNAs; leukemia; hematologic malignancies lncRNAs; leukemia; hematologic malignancies
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Garitano-Trojaola, A.; Agirre, X.; Prósper, F.; Fortes, P. Long Non-Coding RNAs in Haematological Malignancies. Int. J. Mol. Sci. 2013, 14, 15386-15422.

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