MicroRNA: Mechanisms of Action, Physio-Pathological Implications, and Disease Biomarkers

Dear Colleagues,

MicroRNAs (miRNAs) are known to be one of the most widespread non-coding RNAs, contributing to a wide range of biological processes including disease development. Thus, it is critically important to understand the mechanisms by which various miRNAs mediate the post-transcriptional regulation of gene expression. miRNA functions have been extensively investigated in experiments and clinical studies. The exploration of miRNA disease or diagnosis biomarkers has become a popular research topic in recent years. In addition to investigating miRNA biomarkers and miRNA mechanisms, miRNA-based therapeutics such as treatment targeting miRNAs or miRNA drug discovery present potentially challenging tasks for researchers. Diagnosis using miRNA biomarkers and treatment targeting miRNAs are useful strategies in the development of personalized medicine. Moreover, the sequence of many miRNAs is found to be conserved among different organisms. The exploration of miRNA conservation may be beneficial for developing antivirus therapy for variant viruses such as those of coronavirus. This Special Issue invites submissions of reviews and original papers that cover any innovative miRNA research including the study of microRNA functionality by both biological and computational methods, clinical studies addressing miRNA biomarkers and miRNA evolution, and other related subjects.

Prof. Dr. Hsiuying Wang
Prof. Dr. Y-h. Taguchi
Topic Editors