Skin Barrier Function and Immune Mediators as Key Therapeutic Targets of Main Inflammatory Diseases

Dear Colleagues,

Inflammation usually refers to the defensive response of living tissue to inflammatory factors and local damage. The skin, as one of the largest immune organs, is involved in many inflammatory conditions, such as psoriasis, atopic dermatitis, acne, bullous diseases, and hidradenitis suppurativa. These conditions are closely related to severe systemic complications, such as arteriosclerosis, cardiovascular disease, abnormal fat metabolism, nephrosclerosis, and systemic amyloidosis. Timely diagnosis and precision medicine are particularly important for patients, and thus, continued research efforts are required. The following Topic encourages contributors to explore the biological and clinical aspects of the complex interplay between the skin barrier and inflammation, which may act as pivotal actors in the pathogenesis of many diseases. We hope to shed new light on this exciting and insightful field of research from a multidisciplinary perspective. A better understanding of the corresponding pathogenetic mechanisms can aid in the development of new therapeutic agents aimed at eradicating these diseases. We welcome original research papers in addition to critiques and opinion papers. Special clinical cases may also be included. As a part of this Topic, the readership will find accounts of relevant research carried out by numerous healthcare professionals and researchers with extensive knowledge in basic and clinical settings, with the aim of translating basic research into clinical practice.

Dr. Marco Manfredini
Dr. Carlo Pincelli
Topic Editors