Novel Therapeutic Nutrient Molecules, 2nd Volume

Topic Information

Dear Colleagues,

This Topic entitled “Novel Therapeutic Nutrient Molecules, 2nd Volume” will focus on the protective role of bioactive nutrient molecules as a therapeutic approach and against disease pathogenesis. The identification of novel nutrient molecules for therapeutics or to prevent disease pathogenesis has been an attractive approach due to the ease of their translation to the general population. The field of bioactive nutrient molecules protecting against human health outcomes has recently grown thanks to new knowledge. Our Topic Issue will consider original articles, commentaries, and review articles that focus on (but are not limited to) the following potential topics:

• Investigations related to the nutrients of foods and their effects in improving human health;
• Investigations related to novel nutrient compounds and their impact on the human gut microbiome and gut health;
• Investigations related to the gut bioactive metabolites of nutrient molecules and their impact on human health;
• The novel protective roles of vitamins and their metabolites against adverse health outcomes.

Dr. Sathish Kumar Natarajan
Dr. Jiujiu Yu
Dr. Corrine K Hanson
Dr. Melissa Thoene
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
BioMed biomed	-	-	2021	21.9 Days	CHF 1000
Biomedicines biomedicines	3.9	5.2	2013	14.6 Days	CHF 2600
Current Issues in Molecular Biology cimb	2.8	2.9	1999	15.8 Days	CHF 2200
Foods foods	4.7	7.4	2012	14.5 Days	CHF 2900
Nutrients nutrients	4.8	9.2	2009	13.5 Days	CHF 2900

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Published Papers (3 papers)

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All BioMed Biomedicines CIMB Foods Nutrients

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29 pages, 1560 KiB  

Open AccessReview

Unraveling the Biological Properties of Whey Peptides and Their Role as Emerging Therapeutics in Immune Tolerance

by Laura Quintieri, Anna Luparelli, Leonardo Caputo, William Schirinzi, Federica De Bellis, Leonardo Smiriglia and Linda Monaci

Nutrients 2025, 17(6), 938; https://doi.org/10.3390/nu17060938 - 7 Mar 2025

Viewed by 1002

Abstract

Whey is a natural by-product of the cheese-making process and represents a valuable source of nutrients, including vitamins, all essential amino acids and proteins with high quality and digestibility characteristics. Thanks to its different techno-functional characteristics, such as solubility, emulsification, gelling and foaming, [...] Read more.

Whey is a natural by-product of the cheese-making process and represents a valuable source of nutrients, including vitamins, all essential amino acids and proteins with high quality and digestibility characteristics. Thanks to its different techno-functional characteristics, such as solubility, emulsification, gelling and foaming, it has been widely exploited in food manufacturing. Also, advances in processing technologies have enabled the industrial production of a variety of whey-based products exerting biological activities. The beneficial properties of whey proteins (WPs) include their documented effects on cardiovascular, digestive, endocrine, immune and nervous systems, and their putative role in the prevention and treatment of non-communicable diseases (NCDs). In this regard, research on their application for health enhancement, based on the optimization of product formulation and the development of pharmaceuticals, is highly relevant. Beyond the health and nutritionally relevant effects as in in vivo animal studies, the allergenicity of WPs and WP hydrolysates is also herein tackled and discussed, as well as their potential role as therapeutics for immune tolerance and so-called tolerogenic effects. Grounded on the WPs’ health-promoting functions, this paper presents the latest research showing the potential of whey-derived peptides as an alternative strategy in NCD treatment. This work also reports a careful analysis of their current use, also revealing which obstacles limit their full exploitation, thus highlighting the future challenges in the field. Concluding, safety considerations, encompassing WP allergenicity, are also discussed, providing some insights on the role of WPs and peptides in milk allergen immunotolerance. Full article

(This article belongs to the Topic Novel Therapeutic Nutrient Molecules, 2nd Volume)

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11 pages, 905 KiB  

Open AccessArticle

Dietary Inflammatory Potential and Bone Outcomes in Midwestern Post-Menopausal Women

by Mariah Kay Jackson, Laura D. Bilek, Nancy L. Waltman, Jihyun Ma, James R. Hébert, Sherry Price, Laura Graeff-Armas, Jill A. Poole, Lynn R. Mack, Didier Hans, Elizabeth R. Lyden and Corrine Hanson

Nutrients 2023, 15(19), 4277; https://doi.org/10.3390/nu15194277 - 7 Oct 2023

Cited by 6 | Viewed by 3641

Abstract

Little is known about the inflammatory potential of diet and its relation to bone health. This cross-sectional study examined the association between the inflammatory potential of diet and bone-related outcomes in midwestern, post-menopausal women enrolled in the Heartland Osteoporosis Prevention Study (HOPS) randomized [...] Read more.

Little is known about the inflammatory potential of diet and its relation to bone health. This cross-sectional study examined the association between the inflammatory potential of diet and bone-related outcomes in midwestern, post-menopausal women enrolled in the Heartland Osteoporosis Prevention Study (HOPS) randomized controlled trial. Dietary intake from the HOPS cohort was used to calculate Dietary Inflammatory Index (DII^®) scores, which were energy-adjusted (E-DII^TM) and analyzed by quartile. The association between E-DII and lumbar and hip bone mineral density (BMD) and lumbar trabecular bone scores (TBS; bone structure) was assessed using ANCOVA, with pairwise comparison to adjust for relevant confounders (age, education, race/ethnicity, smoking history, family history of osteoporosis/osteopenia, BMI, physical activity, and calcium intake). The cohort included 272 women, who were predominately white (89%), educated (78% with college degree or higher), with a mean BMI of 27 kg/m², age of 55 years, and E-DII score of −2.0 ± 1.9 (more anti-inflammatory). After adjustment, E-DII score was not significantly associated with lumbar spine BMD (p = 0.53), hip BMD (p = 0.29), or TBS at any lumbar location (p > 0.05). Future studies should examine the longitudinal impact of E-DII scores and bone health in larger, more diverse cohorts. Full article

(This article belongs to the Topic Novel Therapeutic Nutrient Molecules, 2nd Volume)

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12 pages, 1702 KiB  

Open AccessArticle

Glutamine Supplementation Preserves Glutamatergic Neuronal Activity in the Infralimbic Cortex, Which Delays the Onset of Mild Cognitive Impairment in 3×Tg-AD Female Mice

by Ji Hyeong Baek, Jae Soon Kang, Miyoung Song, Dong Kun Lee and Hyun Joon Kim

Nutrients 2023, 15(12), 2794; https://doi.org/10.3390/nu15122794 - 19 Jun 2023

Cited by 7 | Viewed by 3060

Abstract

It was recently found that glutamine (Gln) supplementation activates glutamatergic neurotransmission and prevents chronic-stress-induced mild cognitive impairment (MCI). In this study, we evaluated the effects of Gln on glutamatergic activity in the medial prefrontal cortex and the onset of cognitive impairment in a [...] Read more.

It was recently found that glutamine (Gln) supplementation activates glutamatergic neurotransmission and prevents chronic-stress-induced mild cognitive impairment (MCI). In this study, we evaluated the effects of Gln on glutamatergic activity in the medial prefrontal cortex and the onset of cognitive impairment in a triple-transgenic Alzheimer’s disease mouse model (3×Tg-AD). Female 3×Tg-AD mice were fed a normal diet (3×Tg) or a Gln-supplemented diet (3×Tg+Gln) from 2 to 6 months of age. Glutamatergic neuronal activity was analyzed at 6 months, and cognitive function was examined at 2, 4, and 6 months. 3×Tg mice exhibited a decrease in glutamatergic neurotransmission in the infralimbic cortex, but 3×Tg+Gln mice did not. The 3×Tg group showed MCI at 6 months of age, but the 3×Tg+Gln group did not. The expressions of amyloid peptide, inducible nitric oxide synthase, and IBA-1 were not elevated in the infralimbic cortex in the 3×Tg+Gln group. Therefore, a Gln-supplemented diet could delay the onset of MCI even in a mouse model predisposed to cognitive impairment and dementia through genetic modification. Full article

(This article belongs to the Topic Novel Therapeutic Nutrient Molecules, 2nd Volume)

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