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Natural Products to Fight Fungal Infections

Topic Information

Dear Colleagues,

Fungal infections are a growing global threat as they are becoming increasingly resistant to antifungal drugs, thus resulting in rising hospital costs and mortality. According to World Health Organization (WHO) reports, 19 fungi are on the WHO priority pathogen list, and researchers argue that more research is needed to fight these pathogens. Fungal infections are no longer limited to a single geographical region but have spread globally as a result of global warming, international travel, and trade. Mostly, people with cancer, HIV/AIDS, organ transplants, chronic respiratory disease, tuberculosis infection, etc., have a higher risk of invasive fungal infection. As per the present incidence rate and clinical indications, it is predictable that 10 million people die per year because of emerging multidrug resistant fungal species such as Candida, Aspergillus, Cryptococcus, or Pneumocystis. Therefore, newer regimens are urgently needed to tackle these pathogens. Natural compounds are a suitable alternative to use as monotherapy and combined therapy. Reports show that a large number of natural products (e.g., phytochemicals and marine derived compounds) are effective against various fungal species. Alkaloids, polyphenols, steroids, glycosides, and tarpenoids contain unique chemical fractions that prevent or inhibit infections through the reduction in oxidative stress, inhibition, and enzymatic activation and the modulation of the expression of certain genes. In addition, in silico methods may be effective against a target enzyme, and the present in silico platforms are more reliable to locate the most likely active candidate with limited resources and time. As a result, most pharmaceutical and academic research employ various in silico or bioinformatics tools to identify the most promising candidates at the preliminary stage and then move forward with that potent candidate for further in vitro and in vivo studies. This Topic Issue covers the state of novel treatments related to fungal infections through natural compounds. Mainly, it aims to collect basic and translational discoveries and findings on potential antifungal natural compounds using in silico, in vitro, and in vivo methods. The evaluation and validation of new bioactive molecules against fungal pathogens with multidrug resistance patterns are also welcome. In addition, review manuscripts on the gathering and critical analysis of huge sets or databases on natural products for future antifungal drug development are also opportune to be covered in this Topic Issue.

Dr. Célia Fortuna Rodrigues
Dr. Shasank Sekhar Swain
Topic Editors

Keywords

  • fungal infection
  • candida
  • aspergillus
  • cryptococcus
  • natural antifungal candidate
  • drug resistance
  • in silico and in vitro studies
  • molecular docking and simulation
  • toxicity and pharmacokinetics profiles

Participating Journals

Biomedicines
Open Access
14,989 Articles
Launched in 2013
3.9Impact Factor
6.8CiteScore
17 DaysMedian Time to First Decision
Q1Highest JCR Category Ranking
Journal of Fungi
Open Access
6,014 Articles
Launched in 2015
4.0Impact Factor
8.4CiteScore
18 DaysMedian Time to First Decision
Q1Highest JCR Category Ranking
Pharmaceuticals
Open Access
9,464 Articles
Launched in 2004
4.8Impact Factor
7.7CiteScore
14 DaysMedian Time to First Decision
Q1Highest JCR Category Ranking
Pharmaceutics
Open Access
13,333 Articles
Launched in 2009
5.5Impact Factor
10.0CiteScore
15 DaysMedian Time to First Decision
Q1Highest JCR Category Ranking
Reports
Open Access
555 Articles
Launched in 2018
0.6Impact Factor
-CiteScore
22 DaysMedian Time to First Decision
Q3Highest JCR Category Ranking
Molecules
Open Access
61,507 Articles
Launched in 1996
4.6Impact Factor
8.6CiteScore
16 DaysMedian Time to First Decision
Q2Highest JCR Category Ranking

Published Papers