The Blood-Brain Barrier: Cellular Collaboration and Neurological Health

Dear Colleagues,

The bbb (blood–brain barrier) permits essential nutrients to enter and leave the brain by crossing the luminal and abluminal membranes on facilitative carriers. Endothelial cells of brain capillaries are well supplied with mitochondria, which implies that they are capable of energy-related activity. Recently, sodium-dependent carriers have been described on the abluminal membrane, positioned so as to move more than 20 molecules (some of which are osmolytes or medicines) toward the blood. Physiological evidence exists proving that glutamate is actively removed from the brain, leading to the recognition that cerebral capillaries are active, rather than passive, participants in the regulation of the content of soluble molecules in the brain. We invite the submission of articles that relate to the dynamic physiological function of the bbb in regulating the brain’s internal environment.

Prof. Dr. Richard A. Hawkins
Dr. Anna-Maria Barciszewska
Topic Editors