Search Results (2,456)

Radiative cooling (RC) offers a passive pathway to reduce surface and system temperatures by emitting thermal radiation through the atmospheric window, yet its daytime effectiveness is often constrained by geometry, angular solar exposure, and practical integration limits. This work experimentally investigates the use of passive non-imaging optics, specifically compound parabolic concentrators (CPCs), as enhancers of RC performance under realistic conditions. A three-tier experimental methodology is followed. First, controlled indoor screening using an infrared lamp quantifies the intrinsic heat gain suppression of a commercial RC film, showing a temperature reduction of nearly 88 °C relative to a black-painted reference. Second, outdoor rooftop experiments on aluminum plates assess partial RC coverage, with and without CPCs, under varying orientations and tilt angles, revealing peak daytime temperature reductions close to 8 °C when CPCs are integrated. Third, system-level validation is conducted using a modified GUNT ET-202 solar thermal unit to evaluate the transfer of RC effects to a water circuit absorber. While RC strips alone produce modest reductions in water temperature, the addition of CPC optics amplifies the effect by factors of approximately three for ambient water and nine for water at 70 °C. Across all configurations, statistical analysis confirms stable, repeatable measurements. These results demonstrate that coupling commercially available RC materials with non-imaging optics provides consistent and measurable performance gains, supporting CPC-assisted RC as a scalable and retrofit-friendly strategy for urban and building energy applications while calling for longer-term experiments, durability assessments, and techno-economic analysis before deriving definitive deployment guidelines. Full article

Objective: To develop and validate a genetic diagnostic model for colorectal cancer (CRC). Methods: First, differential expression genes (DEGs) between colorectal cancer and normal groups were screened using the TCGA database. Subsequently, a two-sample Mendelian randomization analysis was performed using the eQTL genomic data from the IEU OpenGWAS database and colorectal cancer outcomes from the R12 Finnish database to identify associated genes. The intersecting genes from both methods were selected for the development and validation of the CRC genetic diagnostic model using nine machine learning algorithms: Lasso Regression, XGBoost, Gradient Boosting Machine (GBM), Generalized Linear Model (GLM), Neural Network (NN), Support Vector Machine (SVM), k-Nearest Neighbors (KNN), Random Forest (RF), and Decision Tree (DT). Results: A total of 3716 DEGs were identified from the TCGA database, while 121 genes were associated with CRC based on the eQTL Mendelian randomization analysis. The intersection of these two methods yielded 27 genes. Among the nine machine learning methods, XGBoost achieved the highest AUC value of 0.990. The top five genes predicted by the XGBoost method—RIF1, GDPD5, DBNDD1, RCCD1, and CLDN5—along with the five most significantly differentially expressed genes (ASCL2, IFITM3, IFITM1, SMPDL3A, and SUCLG2) in the GSE87211 dataset, were selected for the construction of the final colorectal cancer (CRC) genetic diagnostic model. The ROC curve analysis revealed an AUC (95% CI) of 0.9875 (0.9737–0.9875) for the training set, and 0.9601 (0.9145–0.9601) for the validation set, indicating strong predictive performance of the model. SHAP model interpretation further identified IFITM1 and DBNDD1 as the most influential genes in the XGBoost model, with both making positive contributions to the model’s predictions. Conclusions: The gene expression profile in colorectal cancer is characterized by enhanced cell proliferation, elevated metabolic activity, and immune evasion. A genetic diagnostic model constructed based on ten genes (RIF1, GDPD5, DBNDD1, RCCD1, CLDN5, ASCL2, IFITM3, IFITM1, SMPDL3A, and SUCLG2) demonstrates strong predictive performance. This model holds significant potential for the early diagnosis and intervention of colorectal cancer, contributing to the implementation of third-tier prevention strategies. Full article

Intercity population flows are playing an increasingly pivotal role in shaping the spatial evolution and structural dynamics of urban networks. Drawing upon Amap Migration Data (2018–2023), this study maps China’s urban networks using social network analysis and identifies their key drivers using a temporal exponential random graph model. The findings reveal three primary insights: First, the overall network exhibits “high connectivity and strong clustering” traits. Enhanced efficiency in intercity resource allocation fosters cross-regional factor flows, resulting in multi-tiered connectivity corridors. Industrial linkages and policy interventions drive the development of a polycentric and clustered configuration. Second, the individual city network exhibits a core–periphery dynamic structure. A diamond-shaped framework dominated by hub cities in the national strategic regions directs factor flows. Development of strategic corridors enables peripheral cities to evolve into secondary hubs by leveraging structural hole advantages, reflecting the continuous interplay between network structure and geo-economic factors. Third, driving factors involve nonlinear interactions within a multi-layered system. Path dependence in topology, gradient potential from nodal attributes, spatial counterbalance between geographic decay laws and multidimensional proximity, and adaptive self-organization are collectively associated with the transition of the urban network toward a multi-tiered synergistic pattern. By revealing the dynamic interplay between network topology and multidimensional driving factors, this study deepens and advances the theoretical connotations of the “Space of Flows” theory, providing an empirical foundation for optimizing regional governance strategies and promoting high-quality coordinated development of Chinese cities. Full article

Perpetual futures account for approximately 93% of cryptocurrency futures trading volume, yet funding rate dynamics across fragmented markets remain understudied. We construct a high-frequency panel dataset comprising 35.7 million one-minute observations across 26 cryptocurrency exchanges (11 centralized, 15 decentralized) spanning 749 symbols over eight consecutive days. Using time-series econometrics, correlation analysis, and Granger causality tests, we characterize funding rate dynamics, market integration, and information flow. We find evidence of a two-tiered market structure: centralized exchanges (CEX) dominate price discovery with 61% higher integration than decentralized exchanges (DEX), and all significant information flow runs CEX-to-DEX with zero reverse causality. While 17% of observations exhibit economically significant arbitrage spreads (≥20 basis points), only 40% of top opportunities generate positive returns after transaction costs and spread reversals. Delta-neutral portfolio simulations reveal that successful arbitrage requires both high spreads and sufficient duration before inevitable reversals, with forced exits occurring in 95% of opportunities. The findings show that cryptocurrency derivatives markets exhibit a persistent two-tiered structure in which centralized platforms dominate price discovery while transaction costs and spread reversal risks prevent arbitrage from eliminating large mispricings between platforms, resolving the apparent paradox of substantial price fragmentation coexisting with market efficiency. Full article

Despite the immense potential of digital intelligence technologies to enhance corporate profitability, manufacturing enterprises often face the “digital–green paradox”, which indicates that while companies invest in digital and intelligent transformation, their energy consumption increases rather than promoting green transition. To provide reasonable transformation solutions for manufacturers still caught in this paradox, this paper adopts a single-case study approach from a product lifecycle perspective. Focusing on FAW-Volkswagen—a manufacturing enterprise demonstrating outstanding performance in digital-intelligent green transformation—this study conducts an in-depth investigation into the stage characteristics and underlying mechanisms. The results show that the following: (1) The digital-intelligent green transformation of manufacturing enterprises is an iterative process evolving from “green design, low-carbon production, intelligent service to enterprise spiral value-added”, with distinct digital-intelligent empowerment models at each stage. (2) By leveraging digital-intelligent technologies, manufacturing enterprises can build a multi-tiered “internal-external dual circulation” green development system encompassing the “enterprise—industrial chain—full ecosystem,” driving comprehensive green upgrades across the entire industry and ecosystem. This paper reveals the intrinsic mechanisms through which digital-intelligent technologies facilitate manufacturing enterprises’ green transformation. It expands and enriches the research context and theoretical implications of product lifecycle management, offering management insights and strategic references for other enterprises pursuing green transformation and upgrading pathways in the digital-intelligent economy era. Full article

Heating, ventilation, and air-conditioning (HVAC) systems dominate energy consumption in hot-climate buildings, where maintaining occupant comfort under extreme outdoor conditions remains a critical challenge, particularly under emerging time-of-use (TOU) electricity pricing schemes. While deep reinforcement learning (DRL) has shown promise for adaptive HVAC control, existing approaches often suffer from comfort violations, myopic decision making, and limited robustness to uncertainty. This paper proposes a comfort-first hybrid control framework that integrates Soft Actor–Critic (SAC) with a Cross-Entropy Method (CEM) refinement layer, referred to as SACEM. The framework combines data-efficient off-policy learning with short-horizon predictive optimization and safety-aware action projection to explicitly prioritize thermal comfort while minimizing energy use, operating cost, and peak demand. The control problem is formulated as a Markov Decision Process using a simplified thermal model representative of commercial buildings in hot desert climates. The proposed approach is evaluated through extensive simulation using Saudi Arabian summer weather conditions, realistic occupancy patterns, and a three-tier TOU electricity tariff. Performance is assessed against state-of-the-art baselines, including PPO, TD3, and standard SAC, using comfort, energy, cost, and peak demand metrics, complemented by ablation and disturbance-based stress tests. Results show that SACEM achieves a comfort score of 95.8%, while reducing energy consumption and operating cost by approximately 21% relative to the strongest baseline. The findings demonstrate that integrating comfort-dominant reward design with decision-time look-ahead yields robust, economically viable HVAC control suitable for deployment in hot-climate smart buildings. Full article

Agricultural marketing increasingly integrates Agriculture 4.0 technologies—Blockchain, AI/ML, IoT, and recommendation systems—yet systematic evaluations of computational maturity and deployment readiness remain limited. This Systematic Literature Review (SLR) examined 99 peer-reviewed studies (2019–2025) from Scopus, Web of Science, and IEEE Xplore following PRISMA protocols to assess algorithmic performance, evaluation methods, and Technology Readiness Levels (TRLs) for agricultural marketing applications. Hybrid recommendation systems dominate current research (28.3%), achieving accuracies of 80–92%, while blockchain implementations (15.2%) show fast transaction times (<2 s) but limited real-world adoption. Machine learning models using Random Forest, Gradient Boosting, and CNNs reach 85–95% predictive accuracy, and IoT systems report >95% data transmission reliability. However, 77.8% of technologies remain at validation stages (TRL ≤ 5), and only 3% demonstrate operational deployment beyond one year. The findings reveal an “efficiency paradox”: strong technical performance (75–97/100) contrasts with weak economic validation (≤20% include cost–benefit analysis). Most studies overlook temporal, geographic, and economic generalization, prioritizing computational metrics over implementation viability. This review highlights the persistent validation–deployment gap in digital agriculture, urging a shift toward multi-tier evaluation frameworks that include contextual, adoption, and impact validation under real deployment conditions. Full article

This study presents a validated framework to quantify regional sea-level risk on U.S. coasts by (i) extracting trends and seasonality from satellite altimetry (ADT, GMSL), (ii) learning regional dynamical regimes via PCA-embedded KMeans on gridded ADT time series, and (iii) coupling these regimes with socioeconomic exposure (population, income, ocean-sector employment/GDP) and wetland submersion scoring. Relative to linear and ARIMA/SARIMA baselines, a sinusoid+trend fit and an LSTM forecaster reduce out-of-sample error (MAE/RMSE) across the North Atlantic, North Pacific, and Gulf of Mexico. The clustering separates high-variability coastal segments, and an interpretable submersion score integrates elevation quantiles and land cover to produce ranked adaptation priorities. Overall, the framework converts heterogeneous physical signals into decision-ready coastal risk tiers to support targeted defenses, zoning, and conservation planning. Full article

In recent years, the development of new diagnostic technologies, such as tandem mass spectrometry (MS/MS) and next-generation sequencing (NGS), has caused a veritable revolution in the diagnosis of genetic diseases, reducing time, cost, and invasiveness associated with prior diagnostic techniques. While MS/MS laid the foundation for the development of numerous, usually institutionally based, neonatal screening programs, NGS has gained traction in newborn screening (NBS), primarily through pilot projects and private funding across different countries. As a result, the traditional Wilson and Jungner criteria have been supplemented by additional criteria, including considerations of equity and access, in response to emerging technologies. This review aims to provide an up-to-date overview of the global landscape of metabolic screening panels, highlight the major ongoing genomic screening projects, and outline the current models for integrating these two screening systems. Substantial differences exist across countries in the numbers and types of diseases included in national NBS programmes. In this context, Italy represents a prominent case, as its neonatal screening framework has seen significant expansion and development in recent years, reaching a particularly comprehensive metabolic screening panel. Nonetheless, a number of initiatives to incorporate genomic technologies into the NBS pathway are currently underway, primarily involving high-income countries. Nonetheless, unlike metabolomic-based NBS programs, no country has a government-mandated NGS program as first-tier testing for newborns. New evidence is emerging from ongoing models of integration of multi-omics approaches into NBS, including the use of AI and machine learning. Identifying the most appropriate system for this integration to reduce the false-positive and false-negative rates associated with both screening types, ensure more equitable access to screening, and facilitate faster access to treatment may represent a useful and foresightful way to conceptualize NBS in the future. This transitional phase should promote rigorous improvements before full-scale adoption. Full article

Urban heat and hardscapes increase cooling electricity demand, stressing power grids and disproportionately burdening deprived neighborhoods. While previous studies have documented the cooling benefits of urban tree canopy, most analyses remain at coarse spatial scales and do not isolate the canopy’s marginal effect from built surfaces, limiting their utility for equitable neighborhood-level planning. We introduce a novel neighborhood-scale (census block-group, CBG) model to estimate cooling-season energy demand across Baltimore City and Baltimore County, Maryland. We quantify demand drivers and actionable tree-canopy targets while controlling for built surfaces. Correlation analysis shows demand increases with developed fraction and imperviousness, and decreases with tree canopy and other vegetated or water cover. Using an explainable monotone gradient-boosted tree model (SHAP) with controls for imperviousness and development, we isolate the canopy’s marginal effect. Demand reductions begin once the canopy exceeds ~11% in Baltimore City and ~23% in Baltimore County, with diminishing returns beyond ~18% (City) and ~24% (County). This flattening is strongest in highly impervious CBGs, while low-impervious county areas show renewed reductions at very high canopy (>55–60%), consistent with forest-dominated microclimates. Spatial hotspots cluster in Baltimore City and southern Baltimore County, where low canopy and high hardscapes coincide with elevated demand; 61% of City CBGs fall below the 18% threshold. We translate these findings into priority intervention tiers combining demand, hardscapes, jurisdiction-specific canopy thresholds, and an equity overlay, identifying 21% of City and 1.2% of County CBGs as high-priority targets for greening and energy-relief interventions. Full article

Amid the normalization of flexible employment, labor dispatch, as a form of non-standard employment, has become an important component of China’s precarious labor market (PLM). Based on registration data of labor dispatch firms from 2002 to 2022, this paper analyzes the spatial distribution and evolutionary patterns of China’s PLM, using spatial autocorrelation, kernel density estimation, and Gini coefficient methods. Furthermore, it explores its driving mechanisms through a panel negative binomial regression model. The results show that (i) over the past two decades, China’s PLM has undergone four stages: initiation, acceleration, expansion, and adjustment. (ii) Spatially, it has evolved along the trend of “reinforced clustering with concurrent diffusion,” expanding from first-tier cities in eastern China to second- and third-tier cities in central and western China. (iii) Industrial upgrading, market competition, and the overall level of urban development have significantly promoted the growth of the PLM, while improvements in accessibility, proportion of migrant population, and public service provision have somewhat restrained its expansion. Overall, China’s PLM demonstrates both growth potential and structural vulnerability under institutional constraints and external shocks, offering valuable spatial insights for forging sustainable, high-quality employment and coordinated regional development. Full article

Ataúro Island, located in the inner Banda Arc, provides a natural laboratory to investigate the interplay between magmatic evolution, hydrothermal circulation, and near-surface weathering in an active arc–continent collision setting. This study presents the first systematic island-wide geochemical baseline for Ataúro Island, based on multi-element analyses of stream sediments integrated with updated geological, structural, and hydromorphological information. Compositional Data Analysis (CoDA–CLR–PCA), combined with anomaly mapping and spatial overlays, defines a coherent three-tier geochemical framework comprising: (i) a lithogenic component dominated by Fe–Ti–Mg–Ni–Co–Cr, reflecting the geochemical signature of basaltic to andesitic volcanic rocks; (ii) a hydrothermal component characterized by Ag–As–Sb–S–Au associations spatially linked to structurally controlled zones; and (iii) an oxidative–supergene component marked by Fe–V–Zn redistribution along drainage convergence areas. These domains are defined strictly on geochemical criteria and represent geochemical process domains rather than proven metallogenic provinces. Rare earth element (REE) systematics further constrain the geotectonic setting and indicate that the primary geochemical patterns are largely controlled by lithological and magmatic differentiation processes. Spatial integration of geochemical patterns with fault architecture highlights the importance of NW–SE and NE–SW structural corridors in focusing hydrothermal fluid circulation and associated metal dispersion. The identified Ag–As–Sb–Au associations are interpreted as epithermal-style hydrothermal geochemical enrichment and exploration-relevant geochemical footprints, rather than as evidence of confirmed or economic mineralization. Overall, Ataúro Island emerges as a compact natural analogue of post-arc geochemical system evolution in the eastern Banda Arc, where lithogenic background, hydrothermal fluid–rock interaction, and early supergene processes are superimposed. The integrated geochemical framework presented here provides a robust baseline for future targeted investigations aimed at distinguishing lithogenic from hydrothermal contributions and evaluating the potential significance of the identified geochemical enrichments. Full article

Insects achieve millisecond sensor–motor loops with tiny sensors, compact neural circuits, and powerful actuators, embodying the principles of Edge AI. We present a comprehensive architectural blueprint translating insect neurobiology into a hardware–software stack: a latency-first control hierarchy that partitions tasks between a fast, dedicated Reflex Tier and a slower, robust Policy Tier, with explicit WCET envelopes and freedom-from-interference boundaries. This architecture is realized through a neuromorphic Reflex Island utilizing spintronic primitives, specifically MRAM synapses (for non-volatile, innate memory) and spin-torque nano-oscillator (STNO) reservoirs (for temporal processing), to enable instant-on, memory-centric reflexes. Furthermore, we formalize the biological governance mechanisms, demonstrating that, unlike conventional ICEs and miniturbines that exhibit narrow best-efficiency islands, insects utilize active thermoregulation and DGC (Discontinuous Gas Exchange) to maintain nearly constant energy efficiency across a broad operational load by actively managing their thermal set-point, which we map into thermal-debt and burst-budget controllers. We instantiate this integrated bio-inspired model in an insect-like IFEVS thruster, a solar cargo e-bike with a neuromorphic safety shell, and other safety-critical edge systems, providing concrete efficiency comparisons, latency, energy budgets, and safety-case hooks that support certification and adoption across autonomous domains. Full article

We present an adaptive governance engine for blockchain-enabled Vehicular Ad Hoc Networks (VANETs) that regulates the latency–energy–coherence trade-off under rapid topology changes. The core contribution is an Ideal Information Cycle (an operational abstraction of information injection/validation) and a modular VANET Engine implemented as a real-time control loop in NS-3.35. At runtime, the Engine monitors normalized Shannon entropies—informational entropy S over active transactions and spatial entropy $H_{\mathrm{spatial}}$ over occupancy bins (both on $[0,1]$)—and adapts the consensus mode (latency-feasible PoW versus signature/quorum-based modes such as PoS/FBA) together with rigor parameters via calibrated policy maps. Governance is formulated as a constrained operational objective that trades per-block resource expenditure (radio + cryptography) against a Quality-of-Information (QoI) proxy derived from delay/error tiers, while maintaining timeliness and ledger-coherence pressure. Cryptographic cost is traced through counted operations, $E_{\mathrm{crypto}}=e_h{n}_{\mathrm{hash}}+e_{\mathrm{sig}}{n}_{\mathrm{sig}}$, and coherence is tracked using the LCP-normalized definition $D_{\mathrm{ledger}}\left(t\right)$ computed from the longest common prefix (LCP) length across nodes. We evaluate the framework under urban/highway mobility, scheduled partitions, and bounded adversarial stressors (Sybil identities and Byzantine proposers), using 600 s runs with 30 matched random seeds per configuration and 95% bias-corrected and accelerated (BCa) bootstrap confidence intervals. In high-disorder regimes ($S\gtrsim 0.8$), the Engine reduces total per-block energy (radio + cryptography) by more than 90% relative to a fixed-parameter PoW baseline tuned to the same agreement latency target. A consensus-first triggering policy further lowers agreement latency and improves throughput compared with broadcast-first baselines. In the emphasized urban setting under high mobility ($v=30$ m/s), the Engine keeps agreement/commit latency in the sub-100 ms range while maintaining finality typically within sub-150 ms ranges, bounds orphaning (≤10%), and reduces average ledger divergence below $0.07$ at high spatial disorder. The main evaluation is limited to $N\le 100$ vehicles under full PHY/MAC fidelity. PoW targets are intentionally latency-feasible and are not intended to provide cryptocurrency-grade majority-hash security; operational security assumptions and mode transition safeguards are discussed in the manuscript. Full article

In this study, an Integrated Energy System (IES) with hydrogen refinement within a tiered carbon trading mechanism (TCTM) is presented to improve energy efficiency and support decarbonization. To address uncertainties in the IES, a distributionally robust optimization (DRO) approach, employing a fuzzy set framework with Kernel Density Estimation (KDE) to construct error distributions and specify output ranges for renewable energy (RE), is proposed. Latin hypercube sampling (LHS) and K-means clustering are, respectively, applied to generate original and representative scenarios. Subsequently, case studies are performed to evaluate advantages of the presented model. The results indicate that hydrogen refinement within the TCTM framework has substantial benefits for the IES. Specifically, the proposed scenario integrates hydrogen blending combustion (HBC) with synthetic methane, demonstrating significant economic and carbon benefits, with cost reductions of 7.3%, 7.1%, and 4.3% and carbon emission reductions of 6%, 3%, and 2.4% compared to scenarios with no hydrogen utilization, HBC only, and synthetic methane only, respectively. In contrast, to exclude carbon trading and include fixed-price trading, the TCTM achieves a 3.5% and 1.1% reduction in carbon emissions, respectively. Finally, a comprehensive sensitivity analysis is performed, examining factors such as the ratio of hydrogen blending, price, and growth rate of carbon trading. Full article