Search Results (14,797)

Cryotherapy and radiofrequency (RF) treatments modulate tissue temperature to induce therapeutic effects; however, improper application can result in thermal injury. Traditional temperature-based monitoring methods rely on multiple thermal sensors whose accuracy strongly depends on their number and spatial positioning, often failing to detect early tissue crystallization. This study introduces a fractional order bioimpedance modelling framework for the early detection of tissue freezing during cryogenic and thermal medical treatments, with the feasibility and effectiveness of this approach having been reported in our prior publications. While bioimpedance spectroscopy itself is a well-est. The corresponablished technique in biomedical engineering, its novel application to predict and identify premature freezing events provides a new pathway for safe and efficient energy-based therapies. Fractional-order models derived from the Cole family accurately reproduce the complex electrical behavior of biological tissues using fewer parameters than classical integer-order models, thus reducing both hardware requirements and computational cost. Experimental impedance data from human abdominal, gluteal, and femoral regions were modelled to extract fractional parameters that serve as sensitive indicators of phase-transition onset. The results demonstrate that the proposed approach enables real-time identification of freezing-induced electrical transitions, offering a physiologically grounded alternative to conventional temperature-based monitoring. Furthermore, the fractional order bioimpedance method exhibits high reproducibility and selectivity, and its analytical figures of merit, including the limits of detection and quantification, support its use for reliable real-time tissue monitoring and early injury detection. Overall, the proposed fractional order bioimpedance framework enhances both safety and control precision in cryogenic and thermal medical applications. Full article

The Indian monsoon is an important component of the tropical climate system. Studies suggest that both precipitation from the NNU-2K AF experiments and Little Ice Age (LIA) proxy data reveal a significant 56-year period in the Indian summer monsoon (ISM). Volcanic activity influences the multi-year and decadal characteristics of Indian monsoon precipitation. A comparative analysis of multi-decadal variations in ISM precipitation from the AF experiments and the single-factor sensitivity experiments shows a correlation of 0.45 (p < 0.05), indicating dependence on volcanic activity. The 56-year period of ISM precipitation in the AF experiments is consistent with both the single-factor sensitivity experiments and precipitation influenced by volcanic activity. Further analysis reveals that cooling over Eurasia and warming of the Indian Ocean weaken the thermal contrast between land and sea, thereby reducing ISM intensity and decreasing ISM precipitation. Conversely, enhanced volcanic activity induces widespread cooling across the Northern Hemisphere, which shifts the Intertropical Convergence Zone (ITCZ) southward. This reduction in evaporative capacity and moisture content within the monsoon region ultimately decreases precipitation across the monsoon belt. Full article

Through the mechanical analysis of AlCoCrFeNi thin-walled high-entropy alloy materials fabricated by plasma arc additive manufacturing, this study examines the practical application prospects of plasma arc manufacturing technology for thin-walled high-entropy alloys and explores its future development directions. Using a plasma arc oscillation process, a 50-layer fine additive experiment was conducted on AlCoCrFeNi high-entropy alloy materials employing both reciprocating and layer-by-layer accumulation methods. The samples were analyzed for overall appearance, microstructure, hardness, and tensile properties. The results indicate that the proportions of columnar and intergranular dendrites in the thin-walled high-entropy alloy specimens are similar, and the columnar dendrites exhibit a uniformly sized cross shape. The variation in Vickers microhardness along the horizontal direction shows lower strength at the edge positions, gradually increasing with horizontal distance. A comparison of the alloy’s transverse and longitudinal tensile specimens revealed that samples parallel to the deposition direction exhibit more regular structural arrangements, while specimens perpendicular to the deposition direction show unavoidable stress concentration at the deposition sites during tensile testing. With the increase in the height of the longitudinal specimens, the FCC structures in the alloy are significantly refined, the organizational arrangement becomes more regular, and the elongation increases. This study elucidates the plasma arc preparation technique for thin-walled high-entropy alloy materials, which is expected to achieve precise control over material composition, accurate observation of grain refinement, and uniform distribution of Vickers hardness, thereby enhancing the mechanical properties and thermal stability of the materials, with promising applications in aerospace, energy, and industrial fields. Full article

This study examined the drilling performance of five polymer composite systems: three natural fiber (jute, flax, hemp) composites with aluminum particle-reinforced epoxy, one glass fiber-reinforced composite with the same matrix, and an unreinforced aluminum particle-filled epoxy (Al–epoxy). Drilling experiments were performed at spindle speeds of 1500 and 3000 rpm with feed rates of 50, 75, and 100 mm/min in order to evaluate the effect of cutting parameters on the drilling performance. Cutting zone temperatures were measured using thermocouples embedded within the drill bit’s cooling channels, while thrust forces were recorded with a dynamometer. Additionally, hole exit damage and inner hole surface roughness were evaluated to assess machining quality. The results showed that increasing spindle speed reduces thrust forces due to thermal softening of the matrix, whereas natural fiber-reinforced composites generally exhibit higher thrust forces and slightly rougher inner hole surfaces compared to synthetic counterparts. During drilling, the measured thrust forces ranged from 320 to 693 N for the glass fiber-reinforced specimen and from 335 to 702 N for the Al–epoxy specimen, while for natural fiber-reinforced composites the thrust force values were 352–679 N for hemp, 241–719 N for jute, and 571–732 N for flax specimens. Synthetic specimens (glass fiber and Al–epoxy) exhibited comparable cutting temperature ranges (288–371 °C and 248–327 °C, respectively), whereas natural fiber-reinforced composites showed higher and broader temperature ranges of 311–389 °C for hemp, 368–374 °C for jute, and 307–379 °C for flax specimens. The overall results indicated that lower forces were generated during the drilling of synthetic glass fiber-reinforced composites, while among natural fiber-reinforced plastics, flax fiber-reinforced composites stood out by exhibiting a balanced machining response. Full article

Controlling bottom hole pressure (BHP) during tripping-out is a key challenge in ultra-deep well drilling. Under high-temperature and high-pressure (HTHP) conditions, ultra-deep wells feature long tripping-out cycles, where thermal effects are prone to causing BHP reduction and increasing kick risk. However, existing pressure control technologies struggle to adapt to the requirements of narrow safe density windows in deep formations. This study establishes a transient tripping-out temperature field model, taking the PS6 ultra-deep vertical well as a case study to calculate the variations in temperature, equivalent static density (ESD), and BHP during tripping-out at 2910 m and 9026 m. A weighted drilling fluid supplementation method is presented, with supplementary parameters designed and its feasibility verified. The results indicate that during the entire tripping-out process, the bottom hole temperature at 2910 m increases by 17.5 °C and BHP rises by 0.016 MPa; at 9026 m, the temperature increases by 72.6 °C and BHP decreases by 2.410 MPa. Compared with the traditional “heavy mud cap” technology, the presented method can control BHP within a smaller fluctuation range (within 0.339 MPa) during tripping-out, better adapting to the safe tripping requirements of narrow safe density windows in deep formations and effectively mitigating kick risk. Full article

Mesozooplankton play a pivotal role in marine pelagic food webs, mediating energy and matter transfer between primary producers and higher trophic levels. Daya Bay, a semi-enclosed bay located in the northern South China Sea, has undergone significant environmental changes due to anthropogenic activities, such as thermal discharge from nuclear power plants and eutrophication. This study examined the mesozooplankton community structure, feeding preferences, and food web organization through four seasonal cruises (May 2022, February 2023, August 2023, and November 2023), employing stable isotope analysis and a Bayesian Isotopic Mixing Model. Results indicate that mesozooplankton abundance and diversity were lower in regions affected by thermal discharge, suggesting a suppressive effect of elevated temperatures. Seasonal shifts in dominant species were observed: Penilia avirostris and Dolioletta gegenbauri dominated the community in spring, while Noctiluca scintillans blooms occurred in summer and winter. Isotopic analysis revealed distinct trophic strategies: copepods exhibited omnivorous habits, whereas cladocerans and tunicates showed stronger herbivorous tendencies. N. scintillans functioned as a high-trophic omnivore, preying on copepod larvae and competing for food resources. Overall, the mesozooplankton community was characterized by an omnivory-dominated trophic network, which enhanced resilience yet remains sensitive to anthropogenic disturbances. This study clarifies how human-induced environmental changes reshape trophic pathways in subtropical coastal waters, providing a valuable reference for long-term monitoring and ecosystem management in Daya Bay. Full article

Cool roof and green roof have been acknowledged as effective heat mitigation strategies for fighting against the urban heat island (UHI). However, empirical data in hot–humid climate are still insufficient. Experimental conventional, cool and green roofs (three types) were established to comprehensively investigate the thermal performances in Hong Kong under typical summer conditions, as retrofitting strategies for an office building. The holistic vertical thermal behavior was investigated. The comparative cooling potentials were assessed. The results reveal a “vertical thermal sequence” in peak temperatures of each substrate layer for the conventional, cool and green roofs on a sunny day. However, local reversion in the thermal sequence may occur on a rainy day. Green roof-plot C (GR_C) demonstrates the highest thermal damping effect, followed by plot B (GR_B), A (GR_A) and the cool roof (CR) in summer. On a sunny day, the thermal dampening effectiveness of the substrates in the three green roofs is consistent: drainage > soil > water reservoir > root barrier. The holistic vertical thermal profiling was constructed in a high-rise office context in Hong Kong. The diurnal temperature profiles indicate all roof systems could effectively attenuate the temperature fluctuations. The daily maximum surface temperature reduction (SDMR) was introduced for cooling potential characterization of the cool roof and green roofs with multiple vegetation types. On a sunny day, the cool roof and green roofs all showed significant cooling potential. SDMR on the concrete tile of the best performing system was GR_C (26 °C), followed by GR_B (22.4 °C), GR_A (20.7 °C) and CR (13.3 °C), respectively. The SDMR on the ceiling ranked as GR_C, GR_B, GR_A and CR, with 2.9 °C, 2.4 °C, 2.1 °C and 2.1 °C, separately. On a rainy day, the cooling effect was still present but greatly diminished. A critical insight of a “warming effect at the ceiling” of the green roof was revealed. This research offers critical insights for unlocking rooftop cooling potential, endorsing cool roof and green roof as pivotal solutions for sustainable urban environments. Full article

Thermal anomalies serve as potential earthquake precursors and are crucial for understanding the mechanisms underlying seismogenic mechanisms and geodynamic perturbations. To address the limited understanding of the polarity evolution of thermal anomalies, we developed a dynamic spatiotemporal adaptive framework to quantify global thermal anomaly responses. Four parameters—the coefficient of determination (R²), spatiotemporal uncertainty (SU), temporal–spatial uncertainty ratio (TSUR), and spatiotemporal correlation coefficient (SCC)—were established to characterize the spatiotemporal patterns of thermal anomaly responses. Additionally, the Anomaly Emphasis Proximity (AEP) was introduced to identify statistically significant thermal anomaly events. The results indicate that the spatiotemporal evolution of thermal anomalies exhibits a transition from pre-earthquake mixed anomalies (both positive and negative) to post-earthquake unipolar anomalies (TIB decreased from 92% to 49%), accompanied by pronounced sea–land differentiation (SST increased from 0.3% to 98.7%). The AEP reveals significant thermal anomaly clustering highly consistent with earthquake activity (e.g., the 2008 Mw 8.0 Wenchuan earthquake in the Qinghai–Tibet Plateau), showing strong correlations in structurally active regions (e.g., SCA and SWS; FDR < 18.5%, STCW > 3.7%) but weaker ones in stable regions (e.g., CNA and ECA). Overall, this framework significantly enhances the robustness and reliability of seismic thermal anomaly detection. Full article

In horizontal condominiums, where standardised designs are often implemented without considering the surroundings, thermal discomfort can be significant. This study compares two thermal discomfort assessment approaches (mean degree-hour and bioclimatic chart) using computer simulations in the EnergyPlus programme, considering different building solar orientations and use patterns. The comparison of approaches allowed the annual percentage of time outside the comfort zone to be quantified. According to the bioclimatic chart, in the most critical room, the proportion of discomfort hours was 16.2%, which could be reduced to 12.3% by changing the solar orientation. According to the mean degree-hour approach, the room with the highest discomfort registered 1.8 mean degree-hours, a value that could decrease to 0.91 by changing the solar orientation. However, it was observed that the use patterns of the rooms may limit the potential for reducing discomfort. Overall, both approaches indicated that north and south orientations tend to lead to less discomfort. However, in some cases, the bioclimatic chart identified east, northeast, and southeast orientations as more suitable alternatives. The differences between the methods were mainly attributed to the parameters adopted by each approach. By analysing different thermal comfort assessment approaches, the study highlights how methodological choices influence the interpretation of thermal discomfort while confirming that solar orientation remains a relevant passive strategy whose effectiveness depends on room use patterns, thereby supporting occupants’ well-being and contributing to environmental and energy sustainability in residential buildings. Full article

Carbon capture is pivotal for achieving carbon neutrality; however, its high energy consumption severely limits the operational flexibility of power plants and remains a key challenge. This study, targeting a full flue gas carbon capture scenario for a 1000 MW coal-fired power plant, identified the dual-element (“steam” and “power generation”) coupling convergence mechanism. Based on this mechanism, a comprehensive set of mathematical model equations for the “carbon–electricity–heat” coupling process is established. This model quantifies the dynamic relationship between key operational parameters (such as unit load, capture rate, and thermal consumption level) and system performance metrics (such as power output and specific power penalty). To address the challenge of flexible operation, this paper further proposes two innovative coupled modes: steam thermal storage and chemical solvent storage. Model-based quantitative analysis indicated the following: (1) The power generation impact rate under full THA conditions (25.7%) is lower than that under 30% THA conditions (27.7%), with the specific power penalty for carbon capture decreasing from 420.7 kW·h/tCO₂ to 366.7 kW·h/tCO₂. (2) Thermal consumption levels of the capture system are a critical influencing factor; each 0.1 GJ/tCO₂ increase in thermal consumption leads to an approximate 2.83% rise in unit electricity consumption. (3) Steam thermal storage mode effectively reduces peak-period capture energy consumption, while the chemical solvent storage mode almost fully eliminates the impact on peak power generation and provides optimal deep peak-shaving capability and operational safety. Furthermore, these modeling results provide a basis for decision-making in plant operations. Full article

Black crust and spalling are common deterioration phenomena affecting marble relics, yet their correlation remains inadequately understood. Hyperspectral imaging, reflectance spectroscopy, portable X-ray Fluorescence (p-XRF), infrared thermography, Scanning Electron Microscopy coupled with Energy-Dispersive Spectroscopy (SEM-EDS), and microbiological analysis was employed to connect these two types of deterioration on the Danbi stone carving of the Confucian Temple in Beijing. Spectral and thermal analyses reveal that black crust significantly reduces reflectance and increase solar absorption by 27%, resulting in thermal stress. p-XRF and SEM-EDS analyses indicated that black crust is enriched in Fe, Ti, Zn, Pb, As and clay minerals, while spalling areas display increase Ca, reflecting substrate exposure. Microscopy reveals microcracks at the layer–substrate interface. Microbiological analyses identify Cladosporium anthropophilum and Alternaria alternata as contributors to surface-darkening. These multi-scale datasets collectively demonstrate that alterations in surface chemistry and bio-mediated darkening promoting the formation of black crusts, which subsequently induce marble spalling due to solar absorption and thermal stress. These findings clarify the coupled physical–chemical–biological pathways through which black crust accelerates stone spalling. Full article

Background/Objectives: The high volatility of volatile drugs significantly restricts their clinical applicability. Although excipients capable of strong interactions can reduce volatilization, conventional screening methods rely on empirical trial-and-error, resulting in low efficiency and high resource consumption. To address this limitation, this study introduces an artificial intelligence (AI)-driven strategy for screening drug–excipient interactions. Using d-borneol as a model drug, this approach aims to efficiently identify strongly interacting excipients and develop stable nano-formulations. Methods: High-throughput simulations were performed using the Protenix structure prediction model to evaluate interactions between d-borneol and 472 FDA-approved excipients. The top 50 candidate excipients were selected based on these simu-lations. Molecular docking and stability experiments were conducted to validate the predictions. Results: Molecular docking and stability experiments confirmed the consistency between predicted and experimental results, validating the model’s reliability. Among the candidates, soybean phospholipid (PC) was identified as the optimal excipient. A lyophilized liposomal formulation prepared with PC significantly suppressed the volatilization of d-borneol and improved both thermal and storage stability. Mechanistic investigations indicated that d-borneol stably incorporates into the hydro-phobic region of phospholipids, enhancing membrane ordering via hydrophobic interactions without disturbing the polar headgroups. Conclusions: This study represents the first application of a structure prediction model to excipient screening for volatile drugs. It successfully addresses the stability challenges associated with d-borneol and offers a new paradigm for developing nano-formulations for volatile pharmaceuticals. Full article

Interactions between surface water and groundwater in arid regions regulate their response to climate and human impacts. In the salar systems of the Altiplano-Puna plateau (Bolivia, Chile, Argentina), understanding how surface waters connect to groundwater is crucial for accurate modeling and assessment. This study introduces new data and analysis using subsurface thermal profiles and modeling to identify flow patterns and possible surface water links. We document, to our knowledge, for the first time in the literature, deep-seated cooling of the subsurface caused by extreme evaporation rates. The subsurface is cooled by 4–5 degrees Celsius below the mean annual air temperature to depths greater than 50 m, even though groundwater inflow waters are elevated by 10 degrees °C due to geothermal heating. Three thermal zones are observed along the southern edge of Salar de Atacama, with temperature dropping from 28 °C to about 12 °C over 2.5 km. A 2D numerical model of groundwater and heat flow was developed to test various hydrological scenarios and understand the factors controlling the thermal regime. Two flow scenarios at the southern margin were examined: a diffuse flow model with uniform flow and flux to the surface and a focused flow model with preferential discharge at a topographic slope break. Results indicate that the focused flow scenario matches thermal data, with warm inflow water discharging into a transition zone between freshwater and brine, cooling through evaporation, re-infiltration, and surface flow, then re-emerging near lagoons at the halite nucleus margin. This research offers valuable insights into the groundwater hydraulics in the Salar de Atacama and can aid in monitoring environmental changes causally linked to lithium mining and upgradient freshwater extraction. Full article

Lost circulation in oil-based drilling fluids (OBDFs) remains difficult to mitigate because particulate lost circulation materials depend on bridging/packing and gel systems for aqueous media often lack OBDF compatibility and controllable in situ sealing. A dual-precursor oil–water biphasic metal–organic supramolecular gel enables rapid in situ sealing in OBDF loss zones. The optimized formulation uses an oil-phase to aqueous gelling-solution volume ratio of 10:3, with 2.0 wt% Span 85, 12.5 wt% TXP-4, and 5.0 wt% NaAlO₂. Apparent-viscosity measurements and ATR–FTIR analysis were used to evaluate the effects of temperature, time, pH, and shear on MOSG gelation. Furthermore, the structural characteristics and performances of MOSGs were systematically investigated by combining microstructural characterization, thermogravimetric analysis, rheological tests, simulated fracture-plugging experiments, and anti-shear evaluations. The results indicate that elevated temperatures (30–70 °C) and mildly alkaline conditions in the aqueous gelling solution (pH ≈ 8.10–8.30) promote P–O–Al coordination and strengthen hydrogen bonding, thereby facilitating the formation of a three-dimensional network. In contrast, strong shear disrupts the nascent network and delays gelation. The optimized MOSGs rapidly exhibit pronounced viscoelasticity and thermal resistance (~193 °C); under high shear (380 rpm), the viscosity retention exceeds 60% and the viscosity recovery exceeds 70%. In plugging tests, MOSG forms a dense sealing layer, achieving a pressure-bearing gradient of 2.27 MPa/m in simulated permeable formations and markedly improving the fracture pressure-bearing capacity in simulated fractured formations. Full article

The current study investigated the effects of geopolymer composites formulated from pumice dust partially replaced by ground granulated blast furnace slag (GGBFS) and fly ash (FA) at levels of 10%, 20%, 30%, and 40% by weight. The mixtures were evaluated for flowability, compressive strength (7, 28, and 56 days), density, and water absorption (28 and 56 days) at ambient temperatures. Moreover, compressive strength, mass loss, density, and water absorption were evaluated after exposure of the mixtures to elevated temperatures (250 °C, 500 °C, and 750 °C) at 28 days. All specimens were initially cured at 60 °C for 24 h, followed by storage under ambient laboratory conditions until testing. The inclusion of GGBFS into the mixtures decreased flowability, and the inclusion of FA resulted in its improvement. At ambient temperature, GGBFS-based mixtures, which were high in calcium content, exhibited substantially superior compressive strength and reduced absorption relative to FA-based mixtures due to the development of dense C-A-S-H gel networks. However, the compressive strength of FA-based mixtures considerably increased when exposed to a temperature of 250 °C. Moreover, at 750 °C, the FA-based mixtures showed superior residual strength (up to 18.1 MPa), lower mass loss, and reduced absorption, indicating enhanced thermal stability due to the dominance of thermally resistant N-A-S-H gels. X-ray diffraction results further supported these trends by showing the rapid deterioration of calcium-rich phases under heat and the comparative stability of aluminosilicate structures in FA-based systems. Overall, the inclusion of up to 40% GGBFS is beneficial for early strength and densification, whereas the incorporation of up to 40% FA improves durability and mechanical retention under high-temperature conditions. Full article