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138 Results Found

  • Feature Paper
  • Article
  • Open Access
2 Citations
681 Views
20 Pages

18 March 2026

Straggler synchronization is a dominant wall-clock bottleneck in synchronous wireless federated learning (FL). Under non-IID data, however, aggressively sampling only fast clients may significantly slow convergence due to statistical heterogeneity. T...

(This article belongs to the Special Issue Foundations and Frontiers of Information Theory—Dedicated to Professor H. Vincent Poor on the Occasion of His 75th Birthday)
  • Article
  • Open Access
670 Views
16 Pages

8 June 2026

ROS 2 employs a publish–subscribe communication model widely used in robotic and distributed systems. As subscriber counts increase, system-level resource contention may influence latency behavior beyond simple message delivery costs. This stud...

(This article belongs to the Section E1: Mathematics and Computer Science)
  • Article
  • Open Access
229 Views
47 Pages

Benchmarking Service-Mesh Scalability in IoT-to-Cloud Microservice Continuums: A Two-Axis Taxonomy and Tail-Latency Evaluation

  • Michail Alexandros Kourtis,
  • Achilleas Economopoulos,
  • George Xilouris,
  • Evangelos Markakis and
  • Ricard Vilalta

10 October 2026

The proliferation of Internet of Things (IoT) devices operating in swarm-like formations—from autonomous device fleets to federated service networks—demands a computing continuum that spans edge nodes, fog gateways, and cloud back-ends. S...

(This article belongs to the Special Issue IoT Meets AI: Driving the Next Generation of Technology)
  • Feature Paper
  • Article
  • Open Access
437 Views
43 Pages

15 September 2026

GPU LDPC latency comparisons across implementations are challenging due to variations in decoder schedules, batch granularity, and timing boundaries. Batch completion was characterized for FP32-layered and flooding decoders on a GPU, considering bloc...

(This article belongs to the Special Issue Performance Criteria for Advanced Wireless Communications)
  • Article
  • Open Access
1,653 Views
45 Pages

28 January 2026

At 300 km/h, an end-to-end vision delay of 100 ms corresponds to 8.3 m of unobserved travel; therefore, real-time anomaly monitoring must balance sensitivity with strict tail-latency constraints at the edge. We propose a hybrid cache–retrieval...

(This article belongs to the Special Issue AI-Driven Image and Video Understanding)
  • Article
  • Open Access
6 Citations
3,731 Views
17 Pages

20 July 2021

The recent development of 3D flash memories has promoted the widespread application of SSDs in modern storage systems by providing large storage capacity and low cost. Garbage collection (GC) as a time-consuming but necessary operation in flash memor...

(This article belongs to the Special Issue Flash Memory Devices)
  • Feature Paper
  • Article
  • Open Access
1 Citations
1,383 Views
52 Pages

21 April 2026

At racing speeds above 300 km/h (≈83 m/s), hazard awareness becomes a vehicular-communications problem: 100 ms already correspond to about 8.3 m of blind travel before an alert can influence braking, line choice, or torque delivery. Cloud-only...

  • Article
  • Open Access
18 Citations
5,610 Views
11 Pages

Spinal Glutamate Transporters Are Involved in the Development of Electroacupuncture Tolerance

  • Luying Cui,
  • Yi Ding,
  • Jie Zeng,
  • Yan Feng and ,
  • Meng Li and
  • Mingxing Ding
  • + 1 author+ 0 author

Background: Electroacupuncture (EA) tolerance is a gradual decline in EA antinociception because of its repeated or prolonged use. This study aims to explore the role of spinal glutamate transporters (GTs) in EA tolerance (EAT). Methods: Rats were tr...

(This article belongs to the Section Biochemistry)
  • Article
  • Open Access
126 Views
27 Pages

Verified State Visibility as a Learning Signal for Block-Pacing Control of Permissioned Ledgers in AI-Native 6G Edge Networks: A Simulation Study

  • Olga Torstensson,
  • Dmytro Prokopovych-Tkachenko,
  • Alona Desiatko,
  • Kostiantyn Babenko and ,
  • Dmytro Tyshchenko and
  • Tamara Franchuk
  • + 1 author+ 0 author

1 November 2026

Artificial intelligence (AI)-native sixth-generation (6G) networks are expected to rely on agents in different administrative domains that coordinate policies, model versions and access rights through shared state. A permissioned ledger can anchor th...

(This article belongs to the Special Issue AI-Native 6G Networks: Architectures, Intelligence, and Emerging Applications)
  • Article
  • Open Access
1 Citations
3,776 Views
15 Pages

While an SSD (Solid State Drive) has been widely used for storage in many computing systems due to its small average latency, how to provide timing guarantees of a delay-sensitive (real-time) task on a real-time system equipped with an SSD has not be...

(This article belongs to the Section Computer Science & Engineering)
  • Article
  • Open Access
9 Citations
4,647 Views
15 Pages

Preemptive Zone Reset Design within Zoned Namespace SSD Firmware

  • Siu Jung,
  • Seungjin Lee,
  • Jungwook Han and
  • Youngjae Kim

Zoned Namespace (ZNS) SSDs address the disadvantages that come from supporting the block interface within conventional SSDs, granting more control over data management to host systems, while also relieving heavy duties from device firmware. However,...

(This article belongs to the Section Computer Science & Engineering)
  • Article
  • Open Access
1,217 Views
34 Pages

Kubernetes Horizontal Pod Autoscaler (HPA) primarily relies on resource-based metrics, such as CPU utilization, which are poorly suited to capturing the latency variability of AI inference workloads. In this paper, we propose a custom-metric-driven a...

(This article belongs to the Section Information and Communication Technologies)
  • Article
  • Open Access

3 November 2026

Multi-tenancy is fundamental to cloud storage, but efficient resource sharing with predictable performance remains challenging because SSD internals are opaque and shared-resource contention increases tail latency. As a result, to meet latency target...

(This article belongs to the Collection Advanced Technologies in Network and Service Management, 2nd Edition)
  • Article
  • Open Access
1 Citations
2,708 Views
19 Pages

Tail Prediction for Heterogeneous Data Center Clusters

  • Sharaf Malebary,
  • Sami Alesawi and
  • Hao Che

30 January 2023

Service providers need to meet their service level objectives (SLOs) to ensure better client experiences. Predicting tail sojourn times of applications is an essential step to combat long tail latency. Therefore, as an attempt to further unravel the...

(This article belongs to the Special Issue Trends of Machine Learning in Multidisciplinary Engineering Processes)
  • Article
  • Open Access
29 Citations
3,662 Views
12 Pages

Synthesis and Investigation of the Analgesic Potential of Enantiomerically Pure Schiff Bases: A Mechanistic Approach

  • Hamid Hussain Afridi,
  • Muhammad Shoaib,
  • Fakhria A. Al-Joufi,
  • Syed Wadood Ali Shah and ,
  • Haya Hussain,
  • Abid Ullah,
  • Mohammad Zahoor and
  • Ehsan Ullah Mughal
  • + 3 authors+ 0 author

15 August 2022

Schiff bases are a class of organic compounds with azomethine moiety, exhibiting a wide range of biological potentials. In this research, six chiral Schiff bases, three ‘S’ series (H1–H3) and three ‘R’ series (H4–H...

(This article belongs to the Section Medicinal Chemistry)
  • Article
  • Open Access
36 Citations
8,258 Views
17 Pages

Delay Analysis in IoT Sensor Networks

  • Asaad Althoubi,
  • Reem Alshahrani and
  • Hassan Peyravi

4 June 2021

Internet of Things (IoT) devices, particularly those used for sensor networks, are often latency-sensitive devices. The topology of the sensor network largely depends on the overall system application. Various configurations include linear, star, hie...

(This article belongs to the Section Sensor Networks)
  • Article
  • Open Access
27 Citations
4,364 Views
12 Pages

The Role of Bidirectional VLC Systems in Low-Latency 6G Vehicular Networks and Comparison with IEEE802.11p and LTE/5G C-V2X

  • Stefano Caputo,
  • Lorenzo Mucchi,
  • Muhammad Ali Umair,
  • Marco Meucci and ,
  • Marco Seminara and
  • Jacopo Catani
  • + 1 author+ 0 author

8 November 2022

In this paper, we present very recent results regarding the latency characterization of a novel bidirectional visible light communication (VLC) system for vehicular applications, which could be relevant in intelligent transportation system (ITS) safe...

(This article belongs to the Special Issue Automotive Visible Light Communications (AutoVLC))
  • Article
  • Open Access
1,660 Views
23 Pages

25 November 2025

Accurate prediction of maximum flow latency is crucial for ensuring the efficient transport of latency-sensitive fronthaul traffic in packet-switched Xhaul networks while maintaining the reliable operation of 5G and beyond Radio Access Networks (RANs...

(This article belongs to the Special Issue Feature Paper Collection in the Section ‘Electrical, Electronics and Communications Engineering’)
  • Article
  • Open Access
3,148 Views
16 Pages

CAL: Core-Aware Lock for the big.LITTLE Multicore Architecture

  • Shiqiang Nie,
  • Yingming Liu,
  • Jie Niu and
  • Weiguo Wu

24 July 2024

The concept of “all cores are created equal” has been popular for several decades due to its simplicity and effectiveness in CPU (Central Processing Unit) design. The more cores the CPU has, the higher performance the host owns and the hi...

(This article belongs to the Section Computing and Artificial Intelligence)
  • Article
  • Open Access
667 Views
20 Pages

Parallel discrete-event simulation (PDES) of register-transfer-level (RTL) designs on multi-socket NUMA platforms demand dynamic load balancing to mitigate barrier-induced tail latency. However, the ultra-fine event granularity of RTL simulation make...

(This article belongs to the Special Issue AI-Enhanced Mixed-Signal Simulation and EDA for Integrated Circuit Design Using CMOS Technologies)
  • Article
  • Open Access
16 Citations
12,627 Views
13 Pages

Evaluation of Topical Anti-Inflammatory Effects of a Gel Formulation with Plantago Lanceolata, Achillea Millefolium, Aesculus Hippocastanum and Taxodium Distichum

  • Anca Zanfirescu,
  • Georgiana Nitulescu,
  • Gheorghe Stancov,
  • Denise Radulescu and ,
  • Cosmin Trif,
  • George Mihai Nitulescu,
  • Simona Negres and
  • Octavian Tudorel Olaru
  • + 3 authors+ 0 author

Medicinal plants hold a significant place as alternative treatments available for inflammatory diseases, with many phytoconstituents being frequently tested in vitro for their biological activities. In the current study, we investigated the in vivo a...

  • Review
  • Open Access
1 Citations
1,074 Views
24 Pages

Latency in IOT-Enabled Digital Twin Systems for Smart Manufacturing: A Review of the Taxonomy and Measurement

  • Jorge Arturo Pinedo Gaucin,
  • Barbara Alexandra Anaya Sánchez,
  • Luis Asunción Pérez-Domínguez,
  • David Luviano-Cruz and ,
  • Roberto Romero López,
  • Nelly Rigaud Téllez,
  • Diana Ortiz-Muñoz and
  • Judith Gallegos Padilla
  • + 3 authors+ 0 author

15 June 2026

The application of Internet of Things (IoT) technology to Digital Twin (DT) in smart manufacturing has opened significant opportunities for real-time monitoring, predictive maintenance, and closed-loop control; however, the inherent latency that exis...

(This article belongs to the Special Issue Challenges, Opportunities and Future Directions in Smart Manufacturing)
  • Article
  • Open Access
1 Citations
2,726 Views
21 Pages

Exploiting Data Duplication to Reduce Data Migration in Garbage Collection Inside SSD

  • Shiqiang Nie,
  • Jie Niu,
  • Chaoyun Yang,
  • Peng Zhang and ,
  • Qiong Yang,
  • Dong Wang and
  • Weiguo Wu
  • + 2 authors+ 0 author

NAND flash memory has been widely adopted as the primary data storage medium in data centers. However, the inherent characteristic of out-of-place updates in NAND flash necessitates garbage collection (GC) operations on NAND flash-based solid-state d...

(This article belongs to the Section Microelectronics)
  • Article
  • Open Access
3 Citations
3,610 Views
11 Pages

Examining the Effects of (α4)3(β2)2 Nicotinic Acetylcholine Receptor-Selective Positive Allosteric Modulator on Acute Thermal Nociception in Rats

  • Farah Deba,
  • Kara Ramos,
  • Matthew Vannoy,
  • Kemburli Munoz and ,
  • Lois S. Akinola,
  • M. Imad Damaj and
  • Ayman K. Hamouda
  • + 2 authors+ 0 author

25 June 2020

Neuronal nicotinic acetylcholine receptor (nAChR)-based therapeutics are sought as a potential alternative strategy to opioids for pain management. In this study, we examine the antinociceptive effects of 3-(2-chlorophenyl)-5-(5-methyl-1-(piperidin-4...

(This article belongs to the Section Chemical Biology)
  • Article
  • Open Access
2 Citations
6,392 Views
18 Pages

11 May 2021

The inclusion of life history as a possible influential factor is pivotal in studies on behavior, welfare, and cognition. Shelter dogs have usually experienced a life involving poor social interactions with humans. Thus, we aimed to investigate the b...

(This article belongs to the Special Issue Human-Animal Interactions and Their Relationships with Animal Welfare, Emotions, and Personality)
  • Article
  • Open Access
509 Views
15 Pages

A Performance Isolation Scheme for Multi-Tenant Shared ZNS SSD

  • Jianjun Cao,
  • Qidong Ding,
  • Xinpeng Xu,
  • Hanze Zhang and ,
  • Ping She and
  • Shiqiang Nie
  • + 1 author+ 0 author

In cloud computing, multi-tenant shared storage is widely used for efficiency. ZNS SSDs have become a popular choice due to their high throughput and low latency. However, they still face challenges: the zone structure is not exposed to tenants, maki...

(This article belongs to the Special Issue New Challenges in High-Performance Computing and Computer Architecture)
  • Article
  • Open Access
54 Citations
4,391 Views
16 Pages

Anti-Inflammatory and Antinociceptive Activities of a Hydroethanolic Extract of Tamarindus indica Leaves

  • Santosh Singh BHADORIYA,
  • Vijay MISHRA,
  • Sushil RAUT,
  • Aditya GANESHPURKAR and
  • Sunil K. JAIN

1 April 2012

The present study aimed to investigate the anti-inflammatory and anti-nociceptive potential of a hydroethanolic extract of Tamarindus indica L. leaves (HTI) along with its possible mode of action. The anti-inflammatory activity of HTI was estimated b...

  • Article
  • Open Access
18 Citations
6,601 Views
14 Pages

Co-administration of Pregabalin and Curcumin Synergistically Decreases Pain-Like Behaviors in Acute Nociceptive Pain Murine Models

  • Sarinee Leksiri,
  • Hasriadi,
  • Peththa Wadu Dasuni Wasana,
  • Opa Vajragupta and ,
  • Pornchai Rojsitthisak and
  • Pasarapa Towiwat
  • + 1 author+ 0 author

11 September 2020

Analgesic drugs in a combination-form can achieve greater efficacy with lesser side effects compared to either drug alone. The combination of drugs acting at different targets or mechanisms of action has been recognized as an alternative approach for...

(This article belongs to the Special Issue Recent Progress in Health Benefits from Curcumin)
  • Article
  • Open Access
4 Citations
10,351 Views
32 Pages

Benchmarking the Responsiveness of Open-Source Text-to-Speech Systems

  • Ha Pham Thien Dinh,
  • Rutherford Agbeshi Patamia,
  • Ming Liu and
  • Akansel Cosgun

23 September 2025

Responsiveness—the speed at which a text-to-speech (TTS) system produces audible output—is critical for real-time voice assistants yet has received far less attention than perceptual quality metrics. Existing evaluations often touch on la...

(This article belongs to the Special Issue Natural Language Processing (NLP) and Large Language Modelling (2nd Edition))
  • Article
  • Open Access
6 Citations
7,964 Views
33 Pages

13 February 2025

This work investigates a new erase scheme in NAND flash memory to improve the lifetime and performance of modern solid-state drives (SSDs). In NAND flash memory, an erase operation applies a high voltage (e.g., >20 V) to flash cells for a long tim...

(This article belongs to the Section Computer Science & Engineering)
  • Article
  • Open Access
7 Citations
4,126 Views
12 Pages

The Anti-Nociceptive Potential of Tulathromycin against Chemically and Thermally Induced Pain in Mice

  • Mohamed Elbadawy,
  • Amira Abugomaa,
  • Hussein M. El-Husseiny,
  • Ahmed S. Mandour and ,
  • Mohamed M. Abdel-Daim,
  • Salama Mostafa Aboelenin,
  • Mohamed Mohamed Soliman and
  • Amany El-Mleeh
  • + 3 authors+ 0 author

The present study was conducted to evaluate the analgesic potential of the new triamilide macrolide antibiotic, tulathromycin, at 20 and 40 mg/kg of body weight (BW), subcutaneously against acute pain in mice. Acute pain was induced either chemically...

(This article belongs to the Special Issue Specific Drug Disposition in Veterinary Medicine)
  • Article
  • Open Access
100 Views
29 Pages

1 November 2026

Shipboard gateways send many sensor channels to shore subscribers with different needs over narrow, intermittent links, yet how Message Queuing Telemetry Transport (MQTT) topic structure, broker placement, Quality of Service (QoS), publishing rate, a...

(This article belongs to the Special Issue Digital Transformation and Smart Infrastructure in Seaports)
  • Article
  • Open Access
3 Citations
1,111 Views
17 Pages

15 February 2026

The low-altitude airspace of bird flocks is gradually shared by unmanned aerial vehicles (UAVs), posing safety risks that necessitate accurate trajectory forecasting. However, existing vision-based methods often treat trajectory prediction and UAV de...

(This article belongs to the Section Intelligent Sensors)
  • Article
  • Open Access
721 Views
17 Pages

Optimizing 1001-Class Handwritten Digit Sequence Recognition for the Mexican Electoral Process Using Asymmetric ResNet-18 and CBAM

  • Miguel Angel Camargo-Rojas,
  • Gabriel Sánchez-Pérez,
  • José Portillo-Portillo,
  • Linda Karina Toscano-Medina and ,
  • Aldo Hernández-Suárez,
  • Jesús Olivares-Mercado and
  • Héctor Manuel Pérez-Meana
  • + 2 authors+ 0 author

8 July 2026

The automated digitization of handwritten electoral results is critical for ensuring transparency and speed in democratic processes. While recurrent sequence-to-sequence models (e.g., CRNN+CTC) achieve high accuracy, they inherently violate the stric...

(This article belongs to the Special Issue Deep Learning Technologies and Their Applications in Image Processing, Computer Vision, and Computational Intelligence)
  • Article
  • Open Access
1,038 Views
28 Pages

23 December 2025

Pipelines that satisfy k-anonymity alone remain vulnerable to attribute disclosure under skewed sensitive attributes. We studied real-time anonymization of high-throughput data streams under strict delay budgets (β). We jointly enforced k-anonym...

(This article belongs to the Section Intelligent Sensors)
  • Article
  • Open Access
5 Citations
3,017 Views
11 Pages

Mating Competition between Wild and Artificially Reared Olive Fruit Flies

  • Anastasia Terzidou,
  • Dimitrios Koveos and
  • Nikos Kouloussis

14 July 2022

Mating success of artificially reared males of the olive fruit fly is essential for genetic control techniques for this pest. We studied the mating competition between males from a laboratory-adapted population reared with an artificial diet and wild...

  • Article
  • Open Access
341 Views
19 Pages

15 September 2026

The quantification of structural resilience and sub-percentile tail risk represents a major challenge across both corporate financial engineering and modern industrial logistics. Traditional aggregation architectures, such as linear risk matrices and...

  • Article
  • Open Access
1 Citations
1,107 Views
24 Pages

Communication-Fairness Trade-Offs in Federated Learning for 6G Resource Allocation: A 200 Client Study

  • Nizamuddin Maitlo,
  • Mahmood Hussain Shah,
  • Abdullah Maitlo,
  • Ghulam Mustafa and ,
  • Kaleem Arshid and
  • Nooruddin Noonari
  • + 1 author+ 0 author

Resource allocation in sixth-generation (6G) networks must meet throughput, latency, and reliability targets while network conditions keep changing. At the same time, the telemetry needed to train good models is distributed across many devices and ed...

(This article belongs to the Section Inventions and Innovation in Electrical Engineering/Energy/Communications)
  • Article
  • Open Access
11 Citations
28,485 Views
12 Pages

3 May 2023

Across all species, communication implies that an emitter sends signals to a receiver, through one or more channels. Cats can integrate visual and auditory signals sent by humans and modulate their behaviour according to the valence of the emotion pe...

(This article belongs to the Section Companion Animals)
  • Article
  • Open Access
16 Citations
3,307 Views
15 Pages

Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone Exert Antinociceptive Activity in the Tail-Flick and Formalin Test in Rodents and Reveal Reduced Gastrotoxicity

  • Marta Szandruk-Bender,
  • Benita Wiatrak,
  • Łukasz Szczukowski,
  • Piotr Świątek and ,
  • Maria Rutkowska,
  • Stanisław Dzimira,
  • Anna Merwid-Ląd,
  • Maciej Danielewski and
  • Adam Szeląg
  • + 4 authors+ 0 author

18 December 2020

Despite the availability of the current drug arsenal for pain management, there is still a clinical need to identify new, more effective, and safer analgesics. Based on our earlier study, newly synthesized 1,3,4-oxadiazole derivatives of pyrrolo[3,4-...

(This article belongs to the Section Molecular Pharmacology)
  • Article
  • Open Access
2 Citations
5,205 Views
15 Pages

24 June 2020

Differentiated I/O services for applications with their own requirements are very important for user satisfaction. Nonvolatile memory express (NVMe) solid-state drive (SSD) architecture can improve the I/O bandwidth with its numerous submission queue...

(This article belongs to the Section Computing and Artificial Intelligence)
  • Article
  • Open Access
4 Citations
3,470 Views
16 Pages

Dual Approach to Depression: The Combined Efficacy of Intermittent Hypoxia and Fluoxetine in Modulating Behavioral and Inflammatory Responses

  • Francini Arboit,
  • Gabriele Cheiran Pereira,
  • Maria Fernanda Pessano Fialho,
  • Gabriela Becker and ,
  • Evelyne da Silva Brum,
  • Micheli Mainardi Pillat,
  • Guilherme Vargas Bochi,
  • Luiz Osório Cruz Portela and
  • Eliane Maria Zanchet
  • + 4 authors+ 0 author

18 September 2024

Background/Objectives: Mental disorders pose a significant public health challenge, affecting millions worldwide. Given the limitations of current therapies, many patients experience inadequate responses and adverse effects. Intermittent hypoxia (IH)...

(This article belongs to the Section Immunology and Immunotherapy)
  • Article
  • Open Access
2 Citations
4,328 Views
19 Pages

Natural Alternatives for Pain Relief: A Study on Morus alba, Angelica archangelica, Valeriana officinalis, and Passiflora incarnata

  • Felicia Suciu,
  • Oana Cristina Șeremet,
  • Emil Ștefănescu,
  • Ciprian Pușcașu and ,
  • Cristina Isabel Viorica Ghiță,
  • Cerasela Elena Gîrd,
  • Robert Viorel Ancuceanu and
  • Simona Negreș
  • + 3 authors+ 0 author

Background: Chronic pain poses a major global health burden, often inadequately managed by conventional analgesics due to limited efficacy and side effects. In this context, plant-based therapies offer a promising alternative. This study aimed to eva...

  • Article
  • Open Access
829 Views
23 Pages

23 May 2026

End-to-end autonomous driving remains fragile in long-tail scenarios, while incorporating vision-language models (VLMs) introduces substantial deliberation latency that cannot interfere with the real-time planning loop. We present ThinkDrive, a dual-...

(This article belongs to the Special Issue Intelligent Control and Applications of Nonlinear Dynamic System)
  • Article
  • Open Access
4 Citations
2,235 Views
9 Pages

In Vivo Evaluation of Anti-Nociceptive Effects of Silver Nanoparticles

  • Shereen Morsi,
  • Valeria Pittala,
  • Mohammad Alqudah,
  • Mohamed Haider and
  • Khaled Greish

26 October 2022

Silver nanoparticles (AgNPs) are widely used commercially due to their antimicrobial effects. Little is known about the effect of AgNPs on neural transmission and pain response. The aim of this study was to assess the anti-nociceptive activity of AgN...

(This article belongs to the Special Issue Multifunctional Nanomaterials for Bioapplications)
  • Article
  • Open Access
1,432 Views
18 Pages

8 January 2026

Efficient metadata and page management are essential for sustaining database performance on modern flash-based storage. However, conventional SQLite configurations—rollback journal and WAL—often trigger excessive small writes and frequent...

  • Article
  • Open Access
8 Citations
6,067 Views
20 Pages

The Influence of Sildenafil–Metformin Combination on Hyperalgesia and Biochemical Markers in Diabetic Neuropathy in Mice

  • Ciprian Pușcașu,
  • Anca Ungurianu,
  • Oana Cristina Șeremet,
  • Corina Andrei and ,
  • Dragoș Paul Mihai and
  • Simona Negreș
  • + 1 author+ 0 author

27 July 2023

Background and objectives: Worldwide, approximately 500 million people suffer from diabetes and at least 50% of these people develop neuropathy. Currently, therapeutic strategies for reducing diabetic neuropathy (DN)-associated pain are limited and h...

(This article belongs to the Section Pharmacology)
  • Article
  • Open Access
7 Citations
3,477 Views
16 Pages

21 September 2024

Bovine herpesvirus type 1 (BoHV-1) establishes lifelong latency in trigeminal ganglionic (TG) neurons following intranasal and ocular infection in cattle. Periodically, the latent virus reactivates in the TG due to stress and is transported anterogra...

(This article belongs to the Section Animal Viruses)
  • Article
  • Open Access
447 Views
22 Pages

Investigating the Anti-Inflammatory and Pain-Relieving Properties of Glaucium corniculatum (L.) Rud subsp. refractum (NAB) Cullen and Glaucium leiocarpum Boiss., Along with Their Active Compounds

  • Melek Karaaslan,
  • Burçin Ergene,
  • Hediye Kamuran İleri,
  • Okan Ekim and ,
  • Özlem Bahadır-Acıkara,
  • Hanefi Özbek,
  • Betül Sever-Yılmaz and
  • Mehmet Levent Altun
  • + 3 authors+ 0 author

4 August 2026

The genus Glaucium (Papaveraceae), comprising approximately 30 species, is widely distributed across the Mediterranean region, Europe, North Africa, and Central and Southwest Asia. In the flora of Türkiye, the genus is represented by 11 taxa and...

(This article belongs to the Special Issue Bioactive Molecules from Natural Sources and Their Functions—2nd Edition)
  • Article
  • Open Access
17 Citations
5,974 Views
19 Pages

5-HT1A Serotonergic, α-Adrenergic and Opioidergic Receptors Mediate the Analgesic Efficacy of Vortioxetine in Mice

  • Nazlı Turan Yücel,
  • Ümmühan Kandemir,
  • Ümide Demir Özkay and
  • Özgür Devrim Can

Vortioxetine is a multimodal antidepressant drug that affects several brain neurochemicals and has the potential to induce various pharmacological effects on the central nervous system. Therefore, we investigated the centrally mediated analgesic effi...

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