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Article

1 Citations

1,689 Views

23 Pages

Chemical Behavior and Bioactive Properties of Spinorphin Conjugated to 5,5′-Dimethyl- and 5,5′-Diphenylhydantoin Analogs

Stela Georgieva,
Petar Todorov,
Jana Tchekalarova,
Subaer Subaer,
Petia Peneva,
Kalin Chakarov,
Hartati Hartati and
Sitti Faika

Pharmaceuticals2024, 17(6), 770;https://doi.org/10.3390/ph17060770

12 June 2024

The discovery of new peptides and their derivatives is an outcome of ongoing efforts to identify a peptide with significant biological activity for effective usage as a possible therapeutic agent. Spinorphin peptides have been documented to exhibit n...

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Article

2,330 Views

17 Pages

Spinorphin Molecules as Opportunities for Incorporation into Spinorphin@AuNPs Conjugate Systems for Potential Sustained Targeted Delivery to the Brain

Stela Georgieva,
Petar Todorov and
Jana Tchekalarova

Pharmaceuticals2025, 18(1), 53;https://doi.org/10.3390/ph18010053

5 January 2025

Background: This study explores the potential for the synthesis of peptide nanosystems comprising spinorphin molecules (with rhodamine moiety: Rh-S, Rh-S5, and Rh-S6) conjugated with nanoparticles (AuNPs), specifically peptide Rh-S@AuNPs, peptide Rh-...

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Article

3 Citations

2,576 Views

18 Pages

Synthesis, Characterization and Biological Investigation of New N-Modified Spinorphin Analogs

Petar Todorov,
Stela Georgieva,
Jana Tchekalarova,
Subaer Subaer,
Petia Peneva and
Hartati Hartati

Pharmaceuticals2022, 15(10), 1251;https://doi.org/10.3390/ph15101251

11 October 2022

The emergence of diverse peptide derivatives has been due to constant efforts to find a specific peptide with pronounced biological activity for effective application as a therapeutic. Spinorphin-peptide products have been reported to possess various...

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Article

7 Citations

2,726 Views

11 Pages

Anti-Inflammatory Effect of Homo- and Heterodimers of Natural Enkephalinase Inhibitors in Experimental Colitis in Mice

Małgorzata Sobocińska,
Maciej Salaga,
Jakub Fichna and
Elżbieta Kamysz

Molecules2020, 25(24), 5820;https://doi.org/10.3390/molecules25245820

10 December 2020

Background: the pharmacological treatment and/or maintenance of remission in inflammatory bowel diseases (IBDs) is currently one of the biggest challenges in the field of gastroenterology. Method: our aim was the synthesis of homo- and heterodimers o...

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Article

5 Citations

2,972 Views

24 Pages

Demystifying DPP III Catalyzed Peptide Hydrolysis—Computational Study of the Complete Catalytic Cycle of Human DPP III Catalyzed Tynorphin Hydrolysis

Antonija Tomić and
Sanja Tomić

Int. J. Mol. Sci.2022, 23(3), 1858;https://doi.org/10.3390/ijms23031858

6 February 2022

Dipeptidyl peptides III (DPP III) is a dual-domain zinc exopeptidase that hydrolyzes peptides of varying sequence and size. Despite attempts to elucidate and narrow down the broad substrate-specificity of DPP III, there is no explanation as to why so...

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