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Article

6 Citations

7,169 Views

12 Pages

Comparative Evaluation of U.S. Brand and Generic Intravenous Sodium Ferric Gluconate Complex in Sucrose Injection: In Vitro Cellular Uptake

Min Wu,
Dajun Sun,
Katherine Tyner,
Wenlei Jiang and
Rodney Rouse

Nanomaterials2017, 7(12), 451;https://doi.org/10.3390/nano7120451

15 December 2017

Iron deficiency anemia is a common clinical consequence for people who suffer from chronic kidney disease, especially those requiring dialysis. Intravenous (IV) iron therapy is a widely accepted safe and efficacious treatment for iron deficiency anem...

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Article

1 Citations

1,781 Views

14 Pages

Intravenous Sodium Ferric Gluconate Complex for Hospitalized Pediatric Patients with Iron Deficiency Anemia

Felicia White,
Noelle Polakowski,
Elena Merlington,
Mara Leimanis,
Brooke Dudick,
Jessica Parker,
Ashley Jousma,
Alexander Loji,
Jeffrey Hanson and
Brian Boville
+ 1 author

Children2025, 12(2), 189;https://doi.org/10.3390/children12020189

5 February 2025

Background/Objectives: Iron deficiency anemia is common in the pediatric population. Red blood cell transfusions, a common acute treatment, pose well-recognized risks including lung injury, circulatory overload, and immune dysfunction. Intravenous ir...

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Article

17 Citations

12,159 Views

18 Pages

Comparative Evaluation of U.S. Brand and Generic Intravenous Sodium Ferric Gluconate Complex in Sucrose Injection: Physicochemical Characterization

Dajun Sun,
Rodney Rouse,
Vikram Patel,
Yong Wu,
Jiwen Zheng,
Alokita Karmakar,
Anil K. Patri,
Priyanka Chitranshi,
David Keire and
Wenlei Jiang
+ 1 author

Nanomaterials2018, 8(1), 25;https://doi.org/10.3390/nano8010025

5 January 2018

The objective of this study was to evaluate physicochemical equivalence between brand (i.e., Ferrlecit) and generic sodium ferric gluconate (SFG) in sucrose injection by conducting a series of comparative in vitro characterizations using advanced ana...

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Article

10 Citations

6,784 Views

15 Pages

Comparative Evaluation of U.S. Brand and Generic Intravenous Sodium Ferric Gluconate Complex in Sucrose Injection: Biodistribution after Intravenous Dosing in Rats

Christopher R. Beekman,
Murali K. Matta,
Christopher D. Thomas,
Adil Mohammad,
Sharron Stewart,
Lin Xu,
Ashok Chockalingam,
Katherine Shea,
Dajun Sun and
Rodney Rouse
+ 2 authors

Nanomaterials2018, 8(1), 10;https://doi.org/10.3390/nano8010010

28 December 2017

Relative biodistribution of FDA-approved innovator and generic sodium ferric gluconate (SFG) drug products was investigated to identify differences in tissue distribution of iron after intravenous dosing to rats. Three equal cohorts of 42 male Spragu...

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12 Citations

7,263 Views

12 Pages

Determination of Non-Transferrin Bound Iron, Transferrin Bound Iron, Drug Bound Iron and Total Iron in Serum in a Rats after IV Administration of Sodium Ferric Gluconate Complex by Simple Ultrafiltration Inductively Coupled Plasma Mass Spectrometric Detection

Murali K. Matta,
Christopher R. Beekman,
Adarsh Gandhi,
Suresh Narayanasamy,
Christopher D. Thomas,
Adil Mohammad,
Sharron Stewart,
Lin Xu,
Ashok Chockalingam and
Rodney Rouse
+ 2 authors

Nanomaterials2018, 8(2), 101;https://doi.org/10.3390/nano8020101

11 February 2018

A rapid, sensitive and specific ultrafiltration inductively-coupled plasma mass spectrometry method was developed and validated for the quantification of non-transferrin bound iron (NTBI), transferrin bound iron (TBI), drug bound iron (DI) and total...

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Article

21 Citations

9,592 Views

10 Pages

Assessment of Dextran Antigenicity of Intravenous Iron Preparations with Enzyme-Linked Immunosorbent Assay (ELISA)

Susann Neiser,
Taija S. Koskenkorva,
Katrin Schwarz,
Maria Wilhelm and
Susanna Burckhardt

Int. J. Mol. Sci.2016, 17(7), 1185;https://doi.org/10.3390/ijms17071185

21 July 2016

Intravenous iron preparations are typically classified as non-dextran-based or dextran/dextran-based complexes. The carbohydrate shell for each of these preparations is unique and is key in determining the various physicochemical properties, the meta...

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