Search Results (931)

This review comprehensively assesses the clinical applications and future potential of alpha-emitting radionuclides available for targeted alpha-particle therapy (TAT) in cancer treatment. The approval of radium-223 therapy in 2013 marked a significant advancement in alpha-emitting therapeutic radiopharmaceuticals, which are primarily used in treatment of prostate cancer. The EU SECURE project was introduced as a major initiative to enhance the sustainability and safety of medical alpha-emitting radionuclides production in Europe. This literature review was conducted by a multidisciplinary team on selected radionuclides, including actinium-225, bismuth-213, astatine-211, lead-212, terbium-149, radium-223 and thorium-227. These were selected based on their clinical significance, as identified in the EU PRISMAP project and subsequent literature searches. The review process involved searching major databases using specific keywords related to alpha-emitter therapy and was limited to articles in English. For each selected radionuclide, the physical characteristics, the radiochemistry, and the pre-clinical and clinical studies are explored. Actinium-225 is the most widely studied alpha emitter, with several preclinical and clinical studies on prostate cancer and neuroendocrine tumours. Other types of tumours (such as glioblastoma) still require preclinical and clinical development. Bismuth-213 bound to antibodies, peptides and nanobodies has shown optimal results in preclinical and clinical studies, with increased median survival and no significant toxicity. Astatine-211 differs from most other α-emitters relevant to TAT, since it yields one α-particle per decay. This offers certain translational advantages, including the simplification of radiation dosimetry calculations and quality control (QC). Lead-212 has the advantage of being an in situ generator with likely widespread availability. Although clinical data are limited, the findings are promising at this stage. The unconventional production of Terbium-149 is the primary reason it has not yet progressed to clinical trials. Overcoming this production obstacle would allow more detailed preclinical investigations. Optimal results with Thorium-227-labelled agents have been observed in preclinical studies, including delays in cellular growth, multiple double-strand breaks and complete regression. Intermediate phase I trial results have also been reported, demonstrating safety and tolerability, as well as an objective response rate of 25%.: The results highlight the advantages of alpha particles in targeting cancer cells with minimal radiation to normal tissue, emphasising the need for high specificity and stability in delivery mechanisms, as well as suggesting that the full clinical potential of alpha particle therapy remains unexplored. Theranostic approach and dosimetric evaluations still represent relevant challenges. Full article

In severe reactor accidents, molten corium solidifies within the core to form a corium crust. Under decay heat, the high-temperature corium crust induces contact melting of internal reactor components. Given the narrow and limited dimensions of these components, this study investigated the contact melting of a corium crust against a stainless steel plate. A three-dimensional plate contact melting model for plate-shaped corium is proposed, with its validity demonstrated through experimental verification. The patterns and factors influencing contact melting were analyzed. The results indicate that under constant heat flux boundary conditions, the melting rate depends solely on the magnitude of the heat flux density, while the effects of the contact surface geometry and heat source mass on the melting rate are negligible. The thickness of the molten liquid film is proportional to both the heat flux density and contact surface area, yet inversely proportional to both the heat source mass and aspect ratio of the contact surface. When the aspect ratio exceeds six, the model can be simplified to two dimensions. Full article

For an induction motor operating as a symmetric three-phase system, the performance of indirect field-oriented vector control relies heavily on the accuracy of the rotor time constant. Any inaccuracies result in severe torque errors and compromise dynamic performance because of the coupling between the flux and torque controls. Although conventional IFOC methods are intended to compensate for the rotor time constant error, they rely on induction machine parameters such as the mutual and leakage inductances. This paper proposes an online method for tuning the rotor time constant independent of other parameters. First, an active power model of three-phase symmetric induction motor is selected to estimate the stator resistance based on a model reference adaptive system, which requires only the rotor time constant. Additionally, high-frequency current injection and torque ripple estimation without phase delay or amplitude decay are introduced to compensate for the rotor time constant. When a high-frequency current is injected, the rotor time constant and stator resistance can be simultaneously tuned without depending on other parameters. A high-frequency current is injected only when a rotor time constant error is detected from the estimated stator resistance. This behavior is enabled by the correlation between the stator resistance and the rotor time constant. Simulation results using MATLAB/Simulink regarding the symmetric three-phase induction motor validate the proposed method. Full article

Litchi downy blight, caused by Peronophythora litchii, is a major postharvest disease that leads to severe pericarp browning and fruit decay, significantly reducing market quality. Strengthening the fruit’s innate defense systems represents a promising strategy for minimizing these losses. This study investigated the efficacy and underlying mechanisms of ethephon treatment in controlling postharvest litchi downy blight. The results showed that treatment with 400 mg·L⁻¹ ethephon solution via a 2-min immersion significantly suppressed P. litchii infection, reduced the disease index and pericarp browning index, and enhanced the rate of ethylene production. Ethephon application notably increased 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, and the activities of key antioxidant and defense-related enzymes, including superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX), chitinase (CHI), β-1,3-glucanase (GLU), and phenylalanine ammonia lyase (PAL). Concurrently, it up-regulated the expression of corresponding genes LcCAT, LcAPX, LcCHI, LcGLU, LcPAL. In contrast, ethephon treatment reduced the accumulation of hydrogen peroxide (H₂O₂) and malondialdehyde (MDA). In summary, ethephon treatment suppresses postharvest litchi downy blight likely through the enhancement of both antioxidant and pathogen defense capacities. These findings provide valuable insights into the potential application of ethephon for maintaining postharvest quality in litchi fruit. Full article

The fruiting stage of soybean (Glycine max L.) is critical for determining both its yield and quality, thereby influencing global production. While some studies have provided partial explanations for the occurrence of Fusarium species on soybean seeds and pods, the fungal diversity affecting soybean pods in Sichuan Province, a major soybean cultivation region in Southwestern China, remains inadequately understood. In this study, 182 infected pods were collected from a maize–soybean relay strip intercropping system. A total of 10 distinct pod-infecting fungal genera (132 isolates) were identified, and their pathogenic potential on soybean seeds and pods was evaluated. Using morphological characteristics and DNA barcode markers, we identified 43 Fusarium isolates belonging to 8 species, including F. verticillioides, F. incarnatum, F. equiseti, F. proliferatum, F. fujikuroi, F. oxysporum, F. chlamydosporum, and F. acutatum through the analysis of the translation elongation factor gene (EF1-α) and RNA polymerases II second largest subunit (RPB2) gene. Multi-locus phylogenetic analysis, incorporating the Internal Transcribed Spacer (rDNA ITS), β-tubulin (β-tubulin), Glyceraldehyde 3-phosphate dehydrogenase (GADPH), Chitin Synthase 1 (CHS-1), Actin (ACT), Beta-tubulin II (TUB2), and Calmodulin (CAL) genes distinguished 37 isolates as 6 Colletotrichum species, including C. truncatum, C. karstii, C. cliviicola, C. plurivorum, C. boninense, and C. fructicola. Among these, F. proliferatum and C. fructicola were the most dominant species, representing 20.93% and 21.62% of the isolation frequency, respectively. Pathogenicity assays revealed significant damage from both Fusarium and Colletotrichum isolates on soybean pods and seeds, with varying isolation frequencies. Of these, F. proliferatum, F. acutatum, and F. verticillioides caused the most severe symptoms. Similarly, within Colletotrichum genus, C. fructicola was the most pathogenic, followed by C. truncatum, C. karstii, C. cliviicola, C. plurivorum, and C. boninense. Notably, F. acutatum, C. cliviicola, C. boninense, and C. fructicola were identified for the first time as pathogens of soybean pods under the maize–soybean strip intercropping system in Southwestern China. These findings highlight emerging virulent pathogens responsible for soybean pod decay and provide a valuable foundation for understanding the pathogen population during the later growth stages of soybean. Full article

Pipeline exfiltration from damaged water-supply systems frequently causes soil erosion and ground subsidence, which jeopardizes the safety of pedestrians and vehicles and even causes casualties. Despite the severe consequences, it is difficult for engineers to give reliable assessments of pipeline exfiltration hazards. In this study, erosion processes were explored using model tests and coupled computational fluid dynamics–discrete element method (CFD-DEM) simulations. It was discovered that the erosion zone can be divided into two zones—the exfiltration zone and the seepage diffusion zone. When water pressure reached 2.412 × 10⁻² MPa, local porosity approached 1.0, indicating there were no soil particles remaining. As pipeline pressure increased from 2.122 × 10⁻³ MPa to 2.412 × 10⁻² MPa, ground failure transitioned from downward settlement to upward bulge, and the ground failure duration of the fractured prototype pipe was reduced by 22–28% (from 125 s to 98 s), with a standard deviation of less than 5. The established exponential decay model ($\mathrm{v}\left(\mathrm{t}\right)={\mathrm{v}}_0{\mathrm{e}}^{(-\mathsf{\alpha }\mathrm{t})},{\mathrm{R}}^2>0.89$) enabled prediction of erosion duration. Based on the erosion height curve, the erosion duration and erosion area in similar engineering environments can be estimated, providing a reference for evaluating the risk of ground collapse due to pipe exfiltration. Full article

Two gold-decorated wooden sculptures of Qing Dynasty collected in Qianjiang Cultural Administration Institute, Chongqing, China, holds significant cultural value. Although in appearance they were preserved completely, the wooden bodies exhibited a certain degree of decay with severe peeling of the surface painted layer and gold lacquer layer. In this study, the samples from the sculptures were characterized by microscopy, SED–EDS (Scanning Electron Microscopy and Energy Dispersive Spectrometer) analysis, and Raman spectroscopy, while the preservation state of wooden core was assessed through the fluorescence microscopy and NREL (National Renewable Energy Laboratory) chemical analysis methods. Findings reveal that the raw material for wooden sculpture is cypress, and holocellulose content of wooden core is as low as 32%. The raw materials for red pigment include cinnabar (HgS) and hematite (Fe₂O₃). There are multiple layers of lacquer and gold can be observed. There is a layer made of clay, gypsum, or brick ash beneath the lacquer layer and colored layer. The gold layer on the surface adopted traditional Chinese gilding technique which is called sticking gold. This study provides insights into the material properties and technological features of these wooden sculptures, offering a reference for future protection of similar sculptures. Full article

Undetected cracks in railroad wheels pose significant safety and economic risks, while current inspection methods are limited by cost, coverage, or contact requirements. This study explores the use of passive, air-coupled ultrasonic acoustic (UA) sensors for detecting wheel damage on stationary or moving wheels. Two controlled datasets of wheelsets, one with clear damage and another with early, service-induced defects, were tested using hammer impacts. An automated system identified high-energy bursts and extracted features in both time and frequency domains, such as decay rate, spectral centroid, and entropy. The results demonstrate the effectiveness of UAE (ultrasonic acoustic emission) techniques through Kernel Density Estimation (KDE) visualization, hypothesis testing with effect sizes, and Receiver Operating Characteristic (ROC) analysis. The decay rate consistently proved to be the most effective discriminator, achieving near-perfect classification of severely damaged wheels and maintaining meaningful separation for early defects. Spectral features provided additional information but were less decisive. The frequency spectrum characteristics were effective across both axial and radial sensor orientations, with ultrasonic frequencies (20–80 kHz) offering higher spectral fidelity than sonic frequencies (1–20 kHz). This work establishes a validated “ground-truth” signature essential for developing a practical wayside detection system. The findings guide a targeted engineering approach to physically isolate this known signature from ambient noise and develop advanced models for reliable in-motion detection. Full article

Electromagnetic Railguns Face Severe Ablation and Melting Risks Due to Extremely High Transient Thermal Loads During High-Speed Launching, Directly Impacting Launch Reliability and Service Life. To address this thermal management challenge, this study proposes and validates the effectiveness of spray cooling technology. Leveraging its high heat transfer coefficient, exceptional critical heat flux (CHF) carrying capacity, and strong transient cooling characteristics, it is particularly suitable for the unsteady thermal control during the initial launch phase. An experimental platform was established, and a three-dimensional numerical model was developed to systematically analyze the dynamic influence mechanisms of nozzle inlet pressure, flow rate, spray angle, and spray distance on cooling performance. Experimental results indicate that the system achieves maximum critical heat flux (CHF) and rail temperature drop at an inlet pressure of 0.5 MPa and a spray angle of 0°. Numerical simulations further reveal that a 45° spray cone angle simultaneously achieves the maximum temperature drop and optimal wall temperature uniformity. Key parameter sensitivity analysis demonstrates that while increasing spray distance leads to larger droplet diameters, the minimal droplet velocity decay combined with a significant increase in overall momentum markedly enhances convective heat transfer efficiency. Concurrently, increasing spray distance effectively improves rail surface temperature uniformity by optimizing the spatial distribution of droplet size and velocity. Full article

Guava (Psidium guajava L.), a perennial species native to tropical regions of the Americas, holds significant economic value and plays an important role in the global fruit industry. Although several reference genomes have been published, population-level genomic studies remain limited, hindering genetic improvement efforts. In this study, we conducted whole genome re-sequencing of 62 guava accessions, primarily from Southern China and Brazil. A total of 4,887,006 high-quality SNPs and 731,469 InDels were identified for population genomic analyses. Phylogenetic and population structure analyses revealed subgroupings that largely corresponded to geographic origins. The data indicated that extensive hybridization between accessions from Brazil and or within China has contributed to the development of many dominant commercial varieties. Genetic diversity analyses showed that Brazilian accessions exhibited higher nucleotide diversity and more rapid linkage disequilibrium decay than those from China. Environmental factors and artificial selection likely imposed selective pressures that shaped guava’s adaptability and agronomic traits. A preliminary genome-wide association study (GWAS) identified PgMYB4 as a candidate gene potentially associated with fruit flesh color. These findings provide novel insights into the genetic diversity, population history, and domestication of guava, and lay a valuable foundation for future breeding and improvement strategies. Full article

Background/Objectives: Untreated dental caries, the single most common health condition globally, is strongly associated with behavioural factors. This study examined dental status and oral health habits in child–parent and sibling pairs. Methods: We retrospectively analysed records from a dental practice in northeastern Poland, including 90 child–parent pairs and 27 sibling pairs. Dental status was assessed using the Decayed-Missing-Filled Teeth (DMFT) index, and treatment completion was measured with the Dental Treatment Index (DTI). Oral health behaviours were also evaluated. Results: Significant differences between children and parents were observed only in the mild-to-moderate caries groups (DMFT I: 27 children vs. 12 parents; DMFT II: 15 children vs. 32 parents). No differences were found in the severe caries or caries-free groups. Children had lower treatment completion than parents in the poorest care group (DTI 1: 20 children vs. 7 parents), but similar outcomes in higher DTI categories. Among siblings, differences appeared only in the DMFT I group, with no differences in treatment completion or behaviours. Conclusions: Strong similarities in extreme dental characteristics between children and parents, comparable DTI values in most groups, and consistent sibling outcomes suggest that family environment strongly influences oral health. Full article

The ‘Akizuki’ pear has become increasingly popular in China in recent years. However, the ‘Akizuki’ pear often suffers from severe rot diseases during the postharvest storage period. Those during storage have not been thoroughly elucidated In this study, fungal pathogens causing postharvest decay of ‘Akizuki’ pear were identified through multi-gene phylogenetic analysis, followed by assessment of the antifungal efficacy of chlorine dioxide (ClO₂) at varying concentrations. A total of 18 strains were isolated and identified as pathogens by Koch postulates. The isolated pathogens were taxonomically identified by combining morphological characterization of hyphae/spores with multi-gene phylogeny (ITS, β-tub, tef1). The results revealed that isolates A1-A11 were identified as Alternaria alternata, D1-D3 as Diaporthe eres, P1 as Penicillium citrinum, and P2-P4 as Penicillium expansum. The strain with the strongest pathogenicity in each genus was selected as the representative strain for subsequent control experiments. ClO₂ significantly inhibited the development of the D. eres, A. alternata, and P. expansum by suppressing mycelial growth and disrupting cell membrane structure of pathogens, in which the EC50 values were 35.56 mg/L, 24.71 mg/L, and 41.98 mg/L, respectively, showing comparable antifungal activity to conventional fungicides. This has clarified the occurrence and control of postharvest decay diseases of ‘Akizuki’ pear fruit and provided more options for the practical applications in postharvest disease control of pear fruits. Full article

This research develops a novel coupled system of nonlinear hybrid stochastic fractional differential equations that integrates neutral effects, stochastic perturbations, and hybrid switching mechanisms. The system is formulated using the Atangana–Baleanu–Caputo fractional operator with a non-singular Mittag–Leffler kernel, which enables accurate representation of memory effects without singularities. Unlike existing approaches, which are limited to either neutral or hybrid stochastic structures, the proposed framework unifies both features within a fractional setting, capturing the joint influence of randomness, history, and abrupt transitions in real-world processes. We establish the existence and uniqueness of mild solutions via the Picard approximation method under generalized Carathéodory-type conditions, allowing for non-Lipschitz nonlinearities. In addition, mean-square Mittag–Leffler stability is analyzed to characterize the boundedness and decay properties of solutions under stochastic fluctuations. Several illustrative examples are provided to validate the theoretical findings and demonstrate their applicability. Full article

In maritime target search missions, UAV swarm task scheduling faces several challenges. These include uncertainties in target states, the high-dimensional multimodal characteristic of the solution space, and dynamic constraints on swarm collaboration. In terms of target position estimation, existing methods ignore the spatiotemporal correlation of target movement. At the level of optimization algorithms, existing algorithms struggle to balance global exploration and local exploitation, and they tend to fall into local optima. To address the above shortcomings, this paper constructs a technical system of “state perception-strategy optimization-collaborative execution”. First, a Serial Memory Iterative Method (GMMIM) integrated with the Gaussian–Markov model is proposed. This method recursively corrects the probability distribution of target positions using historical state data, thereby providing accurate situational support for decision-making. As a result, task scheduling efficiency is improved by 5.36%. Second, the sliding window technique is introduced to improve the Grey Wolf Optimizer (GWO). Based on the convergence of the population’s optimal fitness, the decay rate of the convergence factor is dynamically and adaptively adjusted. This balances the capabilities of global exploration and local exploitation to ensure swarm scheduling efficiency. Simulations demonstrate that the optimization performance of the proposed FSW-GWO algorithm is 16.95% higher than that of the IPSO method. Finally, a dynamic task weight update mechanism is designed. By combining resource load and task timeliness requirements, this mechanism achieves complementary adaptation between swarm resources and tasks. Full article

Background/Objectives: The ongoing prevalence of dental issues within the school-age population continues to present significant public health challenges. This study aims to thoroughly evaluate the oral health conditions of schoolchildren aged 7–10 years, with a particular focus on identifying the prevalence and severity of dental caries, as well as their relationship with dental hygiene and dietary habits. Methods: A cross-sectional approach was employed involving 700 children aged from 7 to 10 years, recruited from nine urban and rural educational institutions across two Romanian counties, namely Mureș and Bistrița-Năsăud. Data were collected regarding the sociodemographic characteristics of participants, including parental educational background and occupational status. Furthermore, information on dental hygiene routines was gathered, encompassing tooth brushing habits, flossing usage, frequency of brushing, along with dietary details such as daily meal count, snacking frequency, and sugar intake levels. An oral examination was performed by a trained specialist to assess the condition of the children’s teeth, documenting the number of decayed, missing, and filled teeth. The presence of plaque was evaluated using a plaque index, and the dental caries status was quantified using the Decayed, Missing, and Filled Teeth (DMFT) index. Results: The findings revealed that the average plaque score was marginally higher in boys (mean = 0.69 ± 0.36) compared to girls (mean = 0.65 ± 0.40). Additionally, children from urban environments demonstrated a mean plaque score of 0.61 ± 0.32, whereas their rural counterparts exhibited a higher score of 0.73 ± 0.38. In multivariable models, irregular brushing, higher daily sugar consumption, and ≥3 snacks/day were independently associated with both caries prevalence (DMFT > 0) and greater DMFT counts (p < 0.05). Conclusions: The evidence denotes a concerning association between poor oral hygiene practices and higher rates of tooth decay among children, particularly among those with elevated sugar intake and frequent snacking behaviors. Dental public health professionals are encouraged to incorporate considerations of oral hygiene habits when developing future health promotion strategies aimed at improving the oral health status of children. Full article