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20 pages, 2385 KiB  
Article
Assessing Thermal Comfort in Green and Conventional Office Buildings in Hot Climates
by Abdulrahman Haruna Muhammad, Ahmad Taki and Sanober Hassan Khattak
Sustainability 2025, 17(15), 7078; https://doi.org/10.3390/su17157078 - 5 Aug 2025
Abstract
Green buildings are recognised for their potential to reduce energy consumption, minimise environmental impact, and improve occupants’ well-being, benefits that are especially critical in rapidly urbanising regions. However, questions remain about whether these buildings fully meet occupant comfort expectations while delivering energy efficiency. [...] Read more.
Green buildings are recognised for their potential to reduce energy consumption, minimise environmental impact, and improve occupants’ well-being, benefits that are especially critical in rapidly urbanising regions. However, questions remain about whether these buildings fully meet occupant comfort expectations while delivering energy efficiency. This is particularly relevant in Africa, where climate conditions and energy infrastructure challenges make sustainable building operation essential. Although interest in sustainable construction has increased, limited research has examined the real-world performance of green buildings in Africa. This study helps address that gap by evaluating indoor thermal comfort in a green-certified office building and two conventional office buildings in Abuja, Nigeria, through post-occupancy evaluation (POE). The Predicted Mean Vote (PMV) and Thermal Sensation Vote (TSV) were used to assess comfort, revealing discrepancies between predicted and actual occupant responses. In the green building, PMV indicated near-neutral conditions (0.28), yet occupants reported a slightly cool sensation (TSV: −1.1). Neutral temperature analysis showed that the TSV-based neutral temperature (26.5 °C) was 2.2 °C higher than the operative temperature (24.3 °C), suggesting overcooling. These findings highlight the importance of incorporating occupant feedback into HVAC control. Aligning cooling setpoints with comfort preferences could improve satisfaction and reduce unnecessary cooling, promoting energy-efficient building operation. Full article
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26 pages, 1697 KiB  
Review
Integrating Climate Risk in Cultural Heritage: A Critical Review of Assessment Frameworks
by Julius John Dimabayao, Javier L. Lara, Laro González Canoura and Steinar Solheim
Heritage 2025, 8(8), 312; https://doi.org/10.3390/heritage8080312 - 4 Aug 2025
Abstract
Climate change poses an escalating threat to cultural heritage (CH), driven by intensifying climate-related hazards and systemic vulnerabilities. In response, risk assessment frameworks and methodologies (RAFMs) have emerged to evaluate and guide adaptation strategies for safeguarding heritage assets. This study conducts a state-of-the-art [...] Read more.
Climate change poses an escalating threat to cultural heritage (CH), driven by intensifying climate-related hazards and systemic vulnerabilities. In response, risk assessment frameworks and methodologies (RAFMs) have emerged to evaluate and guide adaptation strategies for safeguarding heritage assets. This study conducts a state-of-the-art (SotA) review of 86 unique RAFMs using a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-guided systematic approach to assess their scope, methodological rigor, alignment with global climate and disaster risk reduction (DRR) frameworks, and consistency in conceptual definitions of hazard, exposure, and vulnerability. Results reveal a growing integration of Intergovernmental Panel on Climate Change (IPCC)-based climate projections and alignment with international policy instruments such as the Sendai Framework and United Nations Sustainable Development Goals (UN SDGs). However, notable gaps persist, including definitional inconsistencies, particularly in the misapplication of vulnerability concepts; fragmented and case-specific methodologies that challenge comparability; and limited integration of intangible heritage. Best practices include participatory stakeholder engagement, scenario-based modeling, and incorporation of multi-scale risk typologies. This review advocates for more standardized, interdisciplinary, and policy-aligned frameworks that enable scalable, culturally sensitive, and action-oriented risk assessments, ultimately strengthening the resilience of cultural heritage in a changing climate. Full article
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19 pages, 5639 KiB  
Article
Nesting and Hibernation Host Preference of Bamboo Carpenter Bee, Xylocopa (Biluna) tranquebarorum tranquebarorum, and Arthropods Co-Habiting and Re-Using the Bee Nest
by Natsumi Kanzaki, Keito Kobayashi, Keiko Hamaguchi and Yuta Fujimori
Insects 2025, 16(8), 807; https://doi.org/10.3390/insects16080807 (registering DOI) - 4 Aug 2025
Abstract
The bamboo carpenter bee, Xylocopa (Biluna) tranquebarorum tranquebarorum, is native to continental China and Taiwan, and the species invaded Japan around 2006. The bee utilizes bamboo culm for its nesting and hibernation, thereby causing structural damage to bamboo fencing and [...] Read more.
The bamboo carpenter bee, Xylocopa (Biluna) tranquebarorum tranquebarorum, is native to continental China and Taiwan, and the species invaded Japan around 2006. The bee utilizes bamboo culm for its nesting and hibernation, thereby causing structural damage to bamboo fencing and sting injuries to humans. Serious economic and ecological impacts were not expected in the early stage of its invasion. However, its distribution is rapidly expanding in Japan, and thus, its potential impacts need to be evaluated. Since the basic biology of the bee has not been examined in detail, even in its natural range, we examined the basic biology of X. t. tranquebarorum in its invasive range by evaluating its nesting preference and hibernation in several bamboo species collections in Kyoto, Japan. The field survey revealed that the bee prefers dead bamboo internodes with approximately16–28 mm of external diameter, which is well-congruent with previous studies, and does not have strict preference concerning the bamboo species, though the bee prefers Bambusa multiplex and Phyllostachys spp. in its native range. The hibernating bees in the culm sometimes share their nests with other invertebrates, including Anterhynchium gibbifrons, Dinoderus japonicus, Crematogaster matsumurai, unidentified spiders, shield bugs, and lepidopteran larvae. Within these co-habitants, the former two possibly negatively affect nesting and hibernation of the bees. Full article
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22 pages, 3060 KiB  
Article
TOPSIS and AHP-Based Multi-Criteria Decision-Making Approach for Evaluating Redevelopment in Old Residential Projects
by Cheolheung Park, Minwook Son, Jongmyeong Kim, Byeol Kim, Yonghan Ahn and Nahyun Kwon
Sustainability 2025, 17(15), 7072; https://doi.org/10.3390/su17157072 - 4 Aug 2025
Abstract
This research aims to identify and prioritize key planning elements for the redevelopment of such housing complexes by incorporating perspectives from both experts (supply-side) and residents (demand-side). To achieve this, a hybrid multi-criteria decision-making framework was developed by integrating the Analytic Hierarchy Process [...] Read more.
This research aims to identify and prioritize key planning elements for the redevelopment of such housing complexes by incorporating perspectives from both experts (supply-side) and residents (demand-side). To achieve this, a hybrid multi-criteria decision-making framework was developed by integrating the Analytic Hierarchy Process (AHP) and the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS). A total of 25 planning elements were identified through Focus Group Interviews and organized into five domains: legal and institutional reforms, project feasibility, residential conditions, social integration, and complex design. The AHP was used to assess the relative importance of each element based on responses from 30 experts and 130 residents. The analysis revealed a clear divergence in priorities: experts emphasized feasibility and regulatory considerations, while residents prioritized livability and spatial quality. Subsequently, the TOPSIS method was applied to evaluate four real-world redevelopment cases. From the supply-side perspective, Seoul A District received the highest score (0.58), whereas from the demand-side perspective, Gyeonggi D District ranked highest (0.69), illustrating the differing priorities of stakeholders. Overall, Gyeonggi D District emerged as the most favorable option in the combined evaluation. This research contributes a structured and inclusive decision-making framework for the regeneration of public housing. By explicitly comparing and quantifying the contrasting preferences of key stakeholders, it underscores the critical need to balance technical feasibility with resident-centered values in future redevelopment initiatives. Full article
19 pages, 4972 KiB  
Article
Dispersion of TiB2 Particles in Al–Ni–Sc–Zr System Under Rapid Solidification
by Xin Fang, Lei Hu, Peng Rong and Yang Li
Metals 2025, 15(8), 872; https://doi.org/10.3390/met15080872 (registering DOI) - 4 Aug 2025
Abstract
The dispersion behavior of ceramic particles in aluminum alloys during rapid solidification critically affects the resulting microstructure and mechanical performance. In this study, we investigated the nucleation and growth of Al3(Sc,Zr) on TiB2 surfaces in a 2TiB2/Al–8Ni–0.6Sc–0.1Zr alloy, [...] Read more.
The dispersion behavior of ceramic particles in aluminum alloys during rapid solidification critically affects the resulting microstructure and mechanical performance. In this study, we investigated the nucleation and growth of Al3(Sc,Zr) on TiB2 surfaces in a 2TiB2/Al–8Ni–0.6Sc–0.1Zr alloy, fabricated via wedge-shaped copper mold casting and laser surface remelting. Thermodynamic calculations were employed to optimize alloy composition, ensuring sufficient nucleation driving force under rapid solidification conditions. The results show that the formation of Al3(Sc,Zr)/TiB2 composite interfaces is highly dependent on cooling rate and plays a pivotal role in promoting uniform TiB2 dispersion. At an optimal cooling rate (~1200 °C/s), Al3(Sc,Zr) nucleates heterogeneously on TiB2, forming core–shell structures and enhancing particle engulfment into the α-Al matrix. Orientation relationship analysis reveals a preferred (111)α-Al//(0001)TiB2 alignment in Sc/Zr-containing samples. A classical nucleation model quantitatively explains the observed trends and reveals the critical cooling-rate window for composite interface formation. This work provides a mechanistic foundation for designing high-performance aluminum-based composites with uniformly dispersed reinforcements for additive manufacturing applications. Full article
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14 pages, 2070 KiB  
Article
Carcass and Meat Quality Characteristics and Changes of Lean and Fat Pigs After the Growth Turning Point
by Tianci Liao, Mailin Gan, Yan Zhu, Yuhang Lei, Yiting Yang, Qianli Zheng, Lili Niu, Ye Zhao, Lei Chen, Yuanyuan Wu, Lixin Zhou, Jia Xue, Xiaofeng Zhou, Yan Wang, Linyuan Shen and Li Zhu
Foods 2025, 14(15), 2719; https://doi.org/10.3390/foods14152719 - 3 Aug 2025
Viewed by 68
Abstract
Pork is a major global source of animal protein, and improving both its production efficiency and meat quality is a central goal in modern animal agriculture and food systems. This study investigated post-inflection-point growth patterns in two genetically distinct pig breeds—the lean-type Yorkshire [...] Read more.
Pork is a major global source of animal protein, and improving both its production efficiency and meat quality is a central goal in modern animal agriculture and food systems. This study investigated post-inflection-point growth patterns in two genetically distinct pig breeds—the lean-type Yorkshire pig (YP) and the fatty-type Qingyu pig (QYP)—with the aim of elucidating breed-specific characteristics that influence pork quality and yield. Comprehensive evaluations of carcass traits, meat quality attributes, nutritional composition, and gene expression profiles were conducted. After the growth inflection point, carcass traits exhibited greater variability than meat quality traits in both breeds, though with distinct patterns. YPs displayed superior muscle development, with the longissimus muscle area (LMA) increasing rapidly before plateauing at ~130 kg, whereas QYPs maintained more gradual but sustained muscle growth. In contrast, intramuscular fat (IMF)—a key determinant of meat flavor and texture—accumulated faster in YPs post inflection but plateaued earlier in QYPs. Correlation and clustering analyses revealed more synchronized regulation of meat quality traits in QYPs, while YPs showed greater trait variability. Gene expression patterns aligned with these phenotypic trends, highlighting distinct regulatory mechanisms for muscle and fat development in each breed. In addition, based on the growth curves, we calculated the peak age at which the growth rate declined in lean-type and fat-type pigs, which was approximately 200 days for YPs and around 270 days for QYPs. This suggests that these ages may represent the optimal slaughter times for the respective breeds, balancing both economic efficiency and meat quality. These findings provide valuable insights for enhancing pork quality through precision management and offer theoretical guidance for developing breed-specific feeding strategies, slaughter timing, and value-added pork production tailored to consumer preferences in the modern food market. Full article
(This article belongs to the Section Meat)
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14 pages, 6988 KiB  
Article
Effect of Substrate Temperature on the Structural, Morphological, and Infrared Optical Properties of KBr Thin Films
by Teng Xu, Qingyuan Cai, Weibo Duan, Kaixuan Wang, Bojie Jia, Haihan Luo and Dingquan Liu
Materials 2025, 18(15), 3644; https://doi.org/10.3390/ma18153644 - 3 Aug 2025
Viewed by 96
Abstract
Potassium bromide (KBr) thin films were deposited by resistive thermal evaporation at substrate temperatures ranging from 50 °C to 250 °C to systematically elucidate the temperature-dependent evolution of their physical properties. Structural, morphological, and optical characteristics were examined by X-ray diffraction (XRD), scanning [...] Read more.
Potassium bromide (KBr) thin films were deposited by resistive thermal evaporation at substrate temperatures ranging from 50 °C to 250 °C to systematically elucidate the temperature-dependent evolution of their physical properties. Structural, morphological, and optical characteristics were examined by X-ray diffraction (XRD), scanning electron microscopy (SEM), atomic force microscopy (AFM), and Fourier transform infrared spectroscopy (FTIR). The results reveal a complex, non-monotonic response to temperature rather than a simple linear trend. As the substrate temperature increases, growth evolves from a mixed polycrystalline texture to a pronounced (200) preferred orientation. Morphological analysis shows that the film surface is smoothest at 150 °C, while the microstructure becomes densest at 200 °C. These structural variations directly modulate the optical constants: the refractive index attains its highest values in the 150–200 °C window, approaching that of bulk KBr. Cryogenic temperature (6 K) FTIR measurements further demonstrate that suppression of multi-phonon absorption markedly enhances the infrared transmittance of the films. Taken together, the data indicate that 150–200 °C constitutes an optimal process window for fabricating KBr films that combine superior crystallinity, low defect density, and high packing density. This study elucidates the temperature-driven structure–property coupling and offers valuable guidance for optimizing high-performance infrared and cryogenic optical components. Full article
(This article belongs to the Special Issue Obtaining and Characterization of New Materials (5th Edition))
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20 pages, 12851 KiB  
Article
Evaluation of a Vision-Guided Shared-Control Robotic Arm System with Power Wheelchair Users
by Breelyn Kane Styler, Wei Deng, Cheng-Shiu Chung and Dan Ding
Sensors 2025, 25(15), 4768; https://doi.org/10.3390/s25154768 - 2 Aug 2025
Viewed by 165
Abstract
Wheelchair-mounted assistive robotic manipulators can provide reach and grasp functions for power wheelchair users. This in-lab study evaluated a vision-guided shared control (VGS) system with twelve users completing two multi-step kitchen tasks: a drinking task and a popcorn making task. Using a mixed [...] Read more.
Wheelchair-mounted assistive robotic manipulators can provide reach and grasp functions for power wheelchair users. This in-lab study evaluated a vision-guided shared control (VGS) system with twelve users completing two multi-step kitchen tasks: a drinking task and a popcorn making task. Using a mixed methods approach participants compared VGS and manual joystick control, providing performance metrics, qualitative insights, and lessons learned. Data collection included demographic questionnaires, the System Usability Scale (SUS), NASA Task Load Index (NASA-TLX), and exit interviews. No significant SUS differences were found between control modes, but NASA-TLX scores revealed VGS control significantly reduced workload during the drinking task and the popcorn task. VGS control reduced operation time and improved task success but was not universally preferred. Six participants preferred VGS, five preferred manual, and one had no preference. In addition, participants expressed interest in robotic arms for daily tasks and described two main operation challenges: distinguishing wrist orientation from rotation modes and managing depth perception. They also shared perspectives on how a personal robotic arm could complement caregiver support in their home. Full article
(This article belongs to the Special Issue Intelligent Sensors and Robots for Ambient Assisted Living)
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28 pages, 9910 KiB  
Article
Predicting the Next Location of Urban Individuals via a Representation-Enhanced Multi-View Learning Network
by Maoqi Lun, Peixiao Wang, Sheng Wu, Hengcai Zhang, Shifen Cheng and Feng Lu
ISPRS Int. J. Geo-Inf. 2025, 14(8), 302; https://doi.org/10.3390/ijgi14080302 - 2 Aug 2025
Viewed by 94
Abstract
Accurately predicting the next location of urban individuals is a central issue in human mobility research. Human mobility exhibits diverse patterns, requiring the integration of spatiotemporal contexts for location prediction. In this context, multi-view learning has become a prominent method in location prediction. [...] Read more.
Accurately predicting the next location of urban individuals is a central issue in human mobility research. Human mobility exhibits diverse patterns, requiring the integration of spatiotemporal contexts for location prediction. In this context, multi-view learning has become a prominent method in location prediction. Despite notable advances, current methods still face challenges in effectively capturing non-spatial proximity of regional preferences, complex temporal periodicity, and the ambiguity of location semantics. To address these challenges, we propose a representation-enhanced multi-view learning network (ReMVL-Net) for location prediction. Specifically, we propose a community-enhanced spatial representation that transcends geographic proximity to capture latent mobility patterns. In addition, we introduce a multi-granular enhanced temporal representation to model the multi-level periodicity of human mobility and design a rule-based semantic recognition method to enrich location semantics. We evaluate the proposed model using mobile phone data from Fuzhou. Experimental results show a 2.94% improvement in prediction accuracy over the best-performing baseline. Further analysis reveals that community space plays a key role in narrowing the candidate location set. Moreover, we observe that prediction difficulty is strongly influenced by individual travel behaviors, with more regular activity patterns being easier to predict. Full article
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15 pages, 1691 KiB  
Article
tRNA Modifications: A Tale of Two Viruses—SARS-CoV-2 and ZIKV
by Patrick Eldin and Laurence Briant
Int. J. Mol. Sci. 2025, 26(15), 7479; https://doi.org/10.3390/ijms26157479 (registering DOI) - 2 Aug 2025
Viewed by 160
Abstract
tRNA modifications are crucial for efficient protein synthesis, impacting codon recognition, tRNA stability, and translation rates. RNA viruses hijack the host’s translational machinery, including the pool of modified tRNA, to translate their own genomes. However, the mismatch between viral and host codon usage [...] Read more.
tRNA modifications are crucial for efficient protein synthesis, impacting codon recognition, tRNA stability, and translation rates. RNA viruses hijack the host’s translational machinery, including the pool of modified tRNA, to translate their own genomes. However, the mismatch between viral and host codon usage can lead to a limited availability of specific tRNA leading to ribosome stalling, posing a significant challenge for efficient protein translation. While some viruses address this challenge through codon optimization, we show here that SARS-CoV-2 (Coronavirus) and the Zika virus (ZIKV; Flavivirus) adopt a different approach, manipulating the host tRNA epitranscriptome. Analysis of codon bias indices confirmed a substantial divergence between viral and host codon usage, revealing a strong preference in viral genes for codons decoded by tRNAs requiring U34 wobble modification. Monitoring tRNA modification dynamics in infected cells showed that both SARS-CoV2 and ZIKV enhance U34 tRNA modifications during infection. Strikingly, impairing U34 tRNAs profoundly impacted viral replication, underscoring the strict reliance of SARS-CoV-2 and ZIKV on manipulating the host tRNA epitranscriptome to support the efficient translation of their genome. Full article
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14 pages, 3081 KiB  
Article
Habitat Distribution Pattern of François’ Langur in a Human-Dominated Karst Landscape: Implications for Its Conservation
by Jialiang Han, Xing Fan, Ankang Wu, Bingnan Dong and Qixian Zou
Diversity 2025, 17(8), 547; https://doi.org/10.3390/d17080547 - 1 Aug 2025
Viewed by 135
Abstract
The Mayanghe National Nature Reserve, a key habitat for the endangered François’ langur (Trachypithecus francoisi), faces significant anthropogenic disturbances, including extensive distribution of croplands, roads, and settlements. These human-modified features are predominantly concentrated at elevations between 500 and 800 m and [...] Read more.
The Mayanghe National Nature Reserve, a key habitat for the endangered François’ langur (Trachypithecus francoisi), faces significant anthropogenic disturbances, including extensive distribution of croplands, roads, and settlements. These human-modified features are predominantly concentrated at elevations between 500 and 800 m and on slopes of 10–20°, which notably overlap with the core elevation range utilized by François’ langur. Spatial analysis revealed that langurs primarily occupy areas within the 500–800 m elevation band, which comprises only 33% of the reserve but hosts a high density of human infrastructure—including approximately 4468 residential buildings and the majority of cropland and road networks. Despite slopes >60° representing just 18.52% of the area, langur habitat utilization peaked in these steep regions (exceeding 85.71%), indicating a strong preference for rugged karst terrain, likely due to reduced human interference. Habitat type analysis showed a clear preference for evergreen broadleaf forests (covering 37.19% of utilized areas), followed by shrublands. Landscape pattern metrics revealed high habitat fragmentation, with 457 discrete habitat patches and broadleaf forests displaying the highest edge density and total edge length. Connectivity analyses indicated that distribution areas exhibit a more continuous and aggregated habitat configuration than control areas. These results underscore François’ langur’s reliance on steep, forested karst habitats and highlight the urgent need to mitigate human-induced fragmentation in key elevation and slope zones to ensure the species’ long-term survival. Full article
(This article belongs to the Topic Advances in Geodiversity Research)
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23 pages, 1205 KiB  
Article
Uncovering Emotional and Identity-Driven Dimensions of Entertainment Consumption in a Transitional Digital Culture
by Ștefan Bulboacă, Gabriel Brătucu, Eliza Ciobanu, Ioana Bianca Chițu, Cristinel Petrișor Constantin and Radu Constantin Lixăndroiu
Behav. Sci. 2025, 15(8), 1049; https://doi.org/10.3390/bs15081049 - 1 Aug 2025
Viewed by 218
Abstract
This study explores entertainment consumption patterns in Romania, a transitional digital culture characterized by high digital connectivity but underdeveloped physical infrastructure. Employing a dual qualitative coding methodology, this research combines inductive analysis of consumer focus groups with deductive analysis of expert interviews, enabling [...] Read more.
This study explores entertainment consumption patterns in Romania, a transitional digital culture characterized by high digital connectivity but underdeveloped physical infrastructure. Employing a dual qualitative coding methodology, this research combines inductive analysis of consumer focus groups with deductive analysis of expert interviews, enabling a multi-layered interpretation of both overt behaviors and latent emotional drivers. Seven key thematic dimensions, motivational depth, perceived barriers, emotional needs, clarity of preferences, future behavioral intentions, social connection, and identity construction, were analyzed and compared using a Likert-based scoring framework, supported by a radar chart and comparison matrix. Findings reveal both convergence and divergence between consumer and expert perspectives. While consumers emphasize immediate experiences and logistical constraints, experts uncover deeper emotional motivators such as validation, mentorship, and identity formation. This behavioral–emotional gap suggests that, although digital entertainment dominates due to accessibility, it often lacks the emotional richness associated with physical formats, which are preferred but less accessible. This study underscores the importance of triangulated qualitative inquiry in revealing not only stated preferences but also unconscious psychological needs. It offers actionable insights for designing emotionally intelligent and culturally responsive entertainment strategies in digitally saturated yet infrastructure-limited environments. Full article
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12 pages, 776 KiB  
Article
In Vitro Schistosomicidal Activity and Molecular Modeling of Quercitrin and Afzelin Isolated from the Leaves of Copaifera oblongifolia
by Rafael Corrêa Ramos, Lizandra G. Magalhães, Rodrigo C. S. Veneziani, Sérgio R. Ambrósio, Renato Pereira Orenha, Renato Luis Tame Parreira, Márcio L. Andrade e Silva, Jairo K. Bastos, Murilo de Oliveira Souza, Híllary Ozorio Gobeti Caprini, Ana Carla Rangel Rosa, Wanderson Zuza Cosme, Mario F. C. Santos and Wilson R. Cunha
Compounds 2025, 5(3), 30; https://doi.org/10.3390/compounds5030030 - 1 Aug 2025
Viewed by 62
Abstract
Neglected diseases significantly impact the world, and there is a lack of effective treatments, requiring therapeutic alternatives. Thus, the study of the phytochemical and schistosomicidal activity evaluation of Copaifera oblongifolia leaves’ crude extract was conducted. The quercitrin (1) and afzelin ( [...] Read more.
Neglected diseases significantly impact the world, and there is a lack of effective treatments, requiring therapeutic alternatives. Thus, the study of the phytochemical and schistosomicidal activity evaluation of Copaifera oblongifolia leaves’ crude extract was conducted. The quercitrin (1) and afzelin (2) were isolated from the crude extract. In the in vitro schistosomicidal activity test, the isolated compounds demonstrated promising results, with 75% mortality at a concentration of 12.5 µM after 72 h. Molecular docking calculations indicated that compounds 1 and 2 could potentially interact with the amino acids of the FAD binding site in the TGR enzyme, a crucial enzyme for the survival of Schistosoma mansoni. These interactions could have binding energies comparable to praziquantel, a preferred drug for treating schistosomiasis. Therefore, in silico and in vitro investigations are crucial for developing new studies that can reveal the antiparasitic potential of compounds of plant origin. Full article
(This article belongs to the Special Issue Organic Compounds with Biological Activity)
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18 pages, 2864 KiB  
Article
Physiological and Chemical Response of Urochloa brizantha to Edaphic and Microclimatic Variations Along an Altitudinal Gradient in the Amazon
by Hipolito Murga-Orrillo, Luis Alberto Arévalo López, Marco Antonio Mathios-Flores, Jorge Cáceres Coral, Melissa Rojas García, Jorge Saavedra-Ramírez, Adriana Carolina Alvarez-Cardenas, Christopher Iván Paredes Sánchez, Aldi Alida Guerra-Teixeira and Nilton Luis Murga Valderrama
Agronomy 2025, 15(8), 1870; https://doi.org/10.3390/agronomy15081870 - 1 Aug 2025
Viewed by 146
Abstract
Urochloa brizantha (Brizantha) is cultivated under varying altitudinal and management conditions. Twelve full-sun (monoculture) plots and twelve shaded (silvopastoral) plots were established, proportionally distributed at 170, 503, 661, and 1110 masl. Evaluations were conducted 15, 30, 45, 60, and 75 days [...] Read more.
Urochloa brizantha (Brizantha) is cultivated under varying altitudinal and management conditions. Twelve full-sun (monoculture) plots and twelve shaded (silvopastoral) plots were established, proportionally distributed at 170, 503, 661, and 1110 masl. Evaluations were conducted 15, 30, 45, 60, and 75 days after establishment. The conservation and integration of trees in silvopastoral systems reflected a clear anthropogenic influence, evidenced by the preference for species of the Fabaceae family, likely due to their multipurpose nature. Although the altitudinal gradient did not show direct effects on soil properties, intermediate altitudes revealed a significant role of CaCO3 in enhancing soil fertility. These edaphic conditions at mid-altitudes favored the leaf area development of Brizantha, particularly during the early growth stages, as indicated by significantly larger values (p < 0.05). However, at the harvest stage, no significant differences were observed in physiological or productive traits, nor in foliar chemical components, underscoring the species’ high hardiness and broad adaptation to both soil and altitude conditions. In Brizantha, a significant reduction (p < 0.05) in stomatal size and density was observed under shade in silvopastoral areas, where solar radiation and air temperature decreased, while relative humidity increased. Nonetheless, these microclimatic variations did not lead to significant changes in foliar chemistry, growth variables, or biomass production, suggesting a high degree of adaptive plasticity to microclimatic fluctuations. Foliar ash content exhibited an increasing trend with altitude, indicating greater efficiency of Brizantha in absorbing calcium, phosphorus, and potassium at higher altitudes, possibly linked to more favorable edaphoclimatic conditions for nutrient uptake. Finally, forage quality declined with plant age, as evidenced by reductions in protein, ash, and In Vitro Dry Matter Digestibility (IVDMD), alongside increases in fiber, Neutral Detergent Fiber (NDF), and Acid Detergent Fiber (ADF). These findings support the recommendation of cutting intervals between 30 and 45 days, during which Brizantha displays a more favorable nutritional profile, higher digestibility, and consequently, greater value for animal feeding. Full article
(This article belongs to the Section Agricultural Biosystem and Biological Engineering)
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14 pages, 879 KiB  
Article
Axially Disubstituted Silicon(IV) Phthalocyanine as a Potent Sensitizer for Antimicrobial and Anticancer Photo and Sonodynamic Therapy
by Marcin Wysocki, Daniel Ziental, Zekeriya Biyiklioglu, Malgorzata Jozkowiak, Jolanta Dlugaszewska, Hanna Piotrowska-Kempisty, Emre Güzel and Lukasz Sobotta
Int. J. Mol. Sci. 2025, 26(15), 7447; https://doi.org/10.3390/ijms26157447 - 1 Aug 2025
Viewed by 159
Abstract
The unique properties of phthalocyanines (Pcs), such as strong absorption, high photostability, effective singlet oxygen generation, low toxicity and biocompatibility, versatile chemical modifications, broad spectrum of antimicrobial activity, and synergistic effects with other treatment modalities, make them a preferred superior sensitizer in the [...] Read more.
The unique properties of phthalocyanines (Pcs), such as strong absorption, high photostability, effective singlet oxygen generation, low toxicity and biocompatibility, versatile chemical modifications, broad spectrum of antimicrobial activity, and synergistic effects with other treatment modalities, make them a preferred superior sensitizer in the field of antimicrobial photodynamic therapy. The photodynamic and sonodynamic activity of 3-(3-(diethylamino)phenoxy)propanoxy substituted silicon(IV) Pc were evaluated against bacteria and cancer cells. Stability and singlet oxygen generation upon light irradiation and ultrasound (1 MHz, 3 W) were assessed with 1,3-diphenylisobenzofuran. The phthalocyanine revealed high photostability in DMF and DMSO, although the singlet oxygen yields under light irradiation were low. On the other hand, the phthalocyanine revealed excellent sonostability and caused a high rate of DPBF degradation upon excitation by ultrasounds at 1 MHz. The silicon phthalocyanine presented significant bacterial reduction growth, up to 5 log against MRSA and S. epidermidis upon light excitation, whereas the sonodynamic effect was negligible. The phthalocyanine revealed high activity in both photodynamic and sonodynamic manner toward hypopharyngeal tumor (FaDu, 95% and 42% reduction, respectively) and squamous cell carcinoma (SCC-25, 96% and 62% reduction, respectively). The sensitizer showed ca. 30% aldehyde dehydrogenase inhibition in various concentrations and up to 85% platelet-activating factor acetylhydrolase for 0.25 μM, while protease-activated protein C was stimulated up to 66% for 0.75 μM. Full article
(This article belongs to the Section Bioactives and Nutraceuticals)
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