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14 pages, 1282 KiB  
Systematic Review
Actinic Cheilitis: A Systematic Review and Meta-Analysis of Interventions, Treatment Outcomes, and Adverse Events
by Matthäus Al-Fartwsi, Anne Petzold, Theresa Steeb, Lina Amin Djawher, Anja Wessely, Anett Leppert, Carola Berking and Markus V. Heppt
Biomedicines 2025, 13(8), 1896; https://doi.org/10.3390/biomedicines13081896 - 4 Aug 2025
Abstract
Introduction: Actinic cheilitis (AC) is a common precancerous condition affecting the lips, primarily caused by prolonged ultraviolet radiation exposure. Various treatment options are available. However, the optimal treatment approach remains a subject of debate. Objective: To summarize and compare practice-relevant interventions for AC. [...] Read more.
Introduction: Actinic cheilitis (AC) is a common precancerous condition affecting the lips, primarily caused by prolonged ultraviolet radiation exposure. Various treatment options are available. However, the optimal treatment approach remains a subject of debate. Objective: To summarize and compare practice-relevant interventions for AC. Materials and Methods: A pre-defined protocol was registered in PROSPERO (CRD42021225182). Systematic searches in Medline, Embase, and Central, along with manual trial register searches, identified studies reporting participant clearance rates (PCR) or recurrence rates (PRR). Quality assessment for randomized controlled trials (RCTs) was conducted using the Cochrane Risk of Bias tool 2. Uncontrolled studies were evaluated using the tool developed by the National Heart, Lung, and Blood Institute. The generalized linear mixed model was used to pool proportions for uncontrolled studies. A pairwise meta-analysis for RCTs was applied, using the odds ratio (OR) as the effect estimate and the GRADE approach to evaluate the quality of the evidence. Adverse events were analyzed qualitatively. Results: A comprehensive inclusion of 36 studies facilitated an evaluation of 614 participants for PCR, and 430 patients for PRR. Diclofenac showed the lowest PCR (0.53, 95% confidence interval (CI) [0.41; 0.66]), while CO2 laser showed the highest PCR (0.97, 95% CI [0.90; 0.99]). For PRR, Er:YAG laser showed the highest rates (0.14, 95% CI [0.08; 0.21]), and imiquimod the lowest (0.00, 95% CI [0.00; 0.06]). In a pairwise meta-analysis, the OR indicated a lower recurrence rate for Er:YAG ablative fractional laser (AFL)-primed methyl-aminolevulinate photodynamic therapy (MAL-PDT) (Er:YAG AFL-PDT) compared to methyl-aminolevulinate photodynamic therapy (MAL-PDT) alone (OR = 0.22, 95% CI [0.06; 0.82]). The CO2 laser showed fewer local side effects than the Er:YAG laser, while PDTs caused more skin reactions. Due to qualitative data, comparability was limited, highlighting the need for individualized treatment. Conclusions: This study provides a complete and up-to-date evidence synthesis of practice-relevant interventions for AC, identifying the CO2 laser as the most effective treatment and regarding PCR and imiquimod as most effective concerning PRR. Full article
(This article belongs to the Special Issue Skin Diseases and Cell Therapy)
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21 pages, 7111 KiB  
Article
Seasonal Variation in Energy Balance, Evapotranspiration and Net Ecosystem Production in a Desert Ecosystem of Dengkou, Inner Mongolia, China
by Muhammad Zain Ul Abidin, Huijie Xiao, Sanaullah Magsi, Fang Hongxin, Komal Muskan, Phuocthoi Hoang and Muhammad Azher Hassan
Water 2025, 17(15), 2307; https://doi.org/10.3390/w17152307 - 3 Aug 2025
Viewed by 209
Abstract
This study investigates the seasonal dynamics of energy balance, evapotranspiration (ET), and Net Ecosystem Production (NEP) in the Dengkou desert ecosystem of Inner Mongolia, China. Using eddy covariance and meteorological data from 2019 to 2022, the research focuses on understanding how these processes [...] Read more.
This study investigates the seasonal dynamics of energy balance, evapotranspiration (ET), and Net Ecosystem Production (NEP) in the Dengkou desert ecosystem of Inner Mongolia, China. Using eddy covariance and meteorological data from 2019 to 2022, the research focuses on understanding how these processes interact in one of the world’s most water-limited environments. This arid research area received an average of 109.35 mm per annum precipitation over the studied period, classifying the region as a typical arid ecosystem. Seasonal patterns were observed in daily air temperature, with extremes ranging from −20.6 °C to 29.6 °C. Temporal variations in sensible heat flux (H), latent heat flux (LE), and net radiation (Rn) peaked during summer season. The average ground heat flux (G) was mostly positive throughout the observation period, indicating heat transmission from atmosphere to soil, but showed negative values during the winter season. The energy balance ratio for the studied period was in the range of 0.61 to 0.80, indicating challenges in achieving energy closure and ecological shifts. ET exhibited two annual peaks influenced by vegetation growth and climate change, with annual ET exceeding annual precipitation, except in 2021. Net ecosystem production (NEP) from 2019 to 2020 revealed that the Dengkou desert were a net source of carbon, indicating the carbon loss from the ecosystem. In 2021, the Dengkou ecosystem shifted to become a net carbon sink, effectively sequestrating carbon. However, this was sharply reversed in 2022, resulting in a significant net release of carbon. The study findings highlight the complex interactions between energy balance components, ET, and NEP in desert ecosystems, providing insights into sustainable water management and carbon neutrality strategies in arid regions under climate change effect. Full article
(This article belongs to the Special Issue The Observation and Modeling of Surface Air Hydrological Factors)
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20 pages, 6269 KiB  
Article
Miniaturized EBG Antenna for Efficient 5.8 GHz RF Energy Harvesting in Self-Powered IoT and Medical Sensors
by Yahya Albaihani, Rizwan Akram, Abdullah. M. Almohaimeed, Ziyad M. Almohaimeed, Lukman O. Buhari and Mahmoud Shaban
Sensors 2025, 25(15), 4777; https://doi.org/10.3390/s25154777 - 3 Aug 2025
Viewed by 264
Abstract
This study presents a compact and high-efficiency microstrip antenna integrated with a square electromagnetic band-gap (EBG) structure for radio frequency energy harvesting to power battery-less Internet of Things (IoT) sensors and medical devices in the 5.8 GHz Industrial, Scientific, and Medical (ISM) band. [...] Read more.
This study presents a compact and high-efficiency microstrip antenna integrated with a square electromagnetic band-gap (EBG) structure for radio frequency energy harvesting to power battery-less Internet of Things (IoT) sensors and medical devices in the 5.8 GHz Industrial, Scientific, and Medical (ISM) band. The proposed antenna features a compact design with reduced physical dimensions of 36 × 40 mm2 (0.69λo × 0.76λo) while providing high-performance parameters such as a reflection coefficient of −27.9 dB, a voltage standing wave ratio (VSWR) of 1.08, a gain of 7.91 dBi, directivity of 8.1 dBi, a bandwidth of 188 MHz, and radiation efficiency of 95.5%. Incorporating EBG cells suppresses surface waves, enhances gain, and optimizes impedance matching through 50 Ω inset feeding. The simulated and measured results of the designed antenna show a high correlation. This study demonstrates a robust and promising solution for high-performance wireless systems requiring a compact size and energy-efficient operation. Full article
(This article belongs to the Section Biomedical Sensors)
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17 pages, 1801 KiB  
Article
The Influence of Accumulated Radiolysis Products on the Mechanisms of High-Temperature Degradation of Two-Component Lithium-Containing Ceramics
by Inesh E. Kenzhina, Saulet Askerbekov, Artem L. Kozlovskiy, Aktolkyn Tolenova, Sergei Piskunov and Anatoli I. Popov
Ceramics 2025, 8(3), 99; https://doi.org/10.3390/ceramics8030099 (registering DOI) - 3 Aug 2025
Viewed by 236
Abstract
One of the advantages of the EPR spectroscopy method in assessing structural defects caused by irradiation is the fact that using this method it is possible to determine not only the concentration dependences of the defect structure but to also establish their type, [...] Read more.
One of the advantages of the EPR spectroscopy method in assessing structural defects caused by irradiation is the fact that using this method it is possible to determine not only the concentration dependences of the defect structure but to also establish their type, which is not possible with methods such as X-ray diffraction or scanning electron microscopy. Based on the data obtained, the role of variation in the ratio of components in Li4SiO4–Li2TiO3 ceramics on the processes of softening under high-dose irradiation with protons simulating the accumulation of hydrogen in the damaged layer, as well as the concentration of structural defects in the form of oxygen vacancies and radiolysis products on the processes of high-temperature degradation of ceramics, was determined. It was found that the main changes in the defect structure during the prolonged thermal exposure of irradiated samples are associated with the accumulation of oxygen vacancies, the density of which was estimated by the change in the intensity of singlet lithium, characterizing the presence of E-centers. At the same time, it was found that the formation of interphase boundaries in the structure of Li4SiO4–Li2TiO3 ceramics leads to the inhibition of high-temperature degradation processes in the case of post-radiation thermal exposure for a long time. Also, during the conducted studies, the role of thermal effects on the structural damage accumulation rate in Li4SiO4–Li2TiO3 ceramics was determined in the case when irradiation is carried out at different temperatures. During the experiments, it was determined that the main contribution of thermal action in the process of proton irradiation at a fluence of 5 × 1017 proton/cm2 is an increase in the concentration of radiolysis products, described by changes in the intensities of spectral maxima, characterized by the presence of defects such as ≡Si–O, SiO43− and Ti3+ defects. Full article
(This article belongs to the Special Issue Advances in Ceramics, 3rd Edition)
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11 pages, 2015 KiB  
Article
Risk Factors for Radiation-Induced Keratoconjunctivitis Sicca in Dogs Treated with Hypofractionated Intensity-Modulated Radiation Therapy for Intranasal Tumors
by Akihiro Ohnishi, Soichirou Takeda, Yoshiki Okada, Manami Tokoro, Saki Kageyama, Yoshiki Itoh and Taketoshi Asanuma
Animals 2025, 15(15), 2258; https://doi.org/10.3390/ani15152258 - 1 Aug 2025
Viewed by 127
Abstract
Radiation-induced keratoconjunctivitis sicca (KCS) is a significant late complication in dogs receiving radiation therapy for intranasal tumors, particularly with hypofractionated intensity-modulated radiation therapy (IMRT). This retrospective case-control study was performed to identify anatomical and dosimetric risk factors for KCS in 15 canine patients [...] Read more.
Radiation-induced keratoconjunctivitis sicca (KCS) is a significant late complication in dogs receiving radiation therapy for intranasal tumors, particularly with hypofractionated intensity-modulated radiation therapy (IMRT). This retrospective case-control study was performed to identify anatomical and dosimetric risk factors for KCS in 15 canine patients treated with IMRT delivered in 4–6 weekly fractions of 8 Gy. Orbital structures were retrospectively contoured, and dose–volume metrics (D50) were calculated. Receiver operating characteristic (ROC) curve analysis and odds ratios were used to evaluate the associations between radiation dose and KCS development. Six dogs (33%) developed KCS within three months post-treatment. Statistically significant dose differences were observed between affected and unaffected eyes for the eyeball, cornea, and retina. ROC analyses identified dose thresholds predictive of KCS: 13.8 Gy (eyeball), 14.9 Gy (cornea), and 17.0 Gy (retina), with the retina showing the highest odds ratio (28.33). To ensure clinical relevance, KCS was diagnosed based on decreased tear production combined with corneal damage to ensure clinical relevance. This study proposes dose thresholds for ocular structures that may guide treatment planning and reduce the risk of KCS in canine patients undergoing IMRT. Further prospective studies are warranted to validate these thresholds and explore mitigation strategies for high-risk cases. Full article
(This article belongs to the Special Issue Imaging Techniques and Radiation Therapy in Veterinary Medicine)
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11 pages, 217 KiB  
Article
Brain Injury Patterns and Short-TermOutcomes in Late Preterm Infants Treated with Hypothermia for Hypoxic Ischemic Encephalopathy
by Aslihan Kose Cetinkaya, Fatma Nur Sari, Avni Merter Keceli, Mustafa Senol Akin, Seyma Butun Turk, Omer Ertekin and Evrim Alyamac Dizdar
Children 2025, 12(8), 1012; https://doi.org/10.3390/children12081012 - 31 Jul 2025
Viewed by 192
Abstract
Background: Hypoxic–ischemic encephalopathy (HIE) is a leading cause of severe neurological impairments in childhood. Therapeutic hypothermia (TH) is both safe and effective in neonates born at ≥36 weeks gestation with moderate to severe HIE. We aimed to evaluate short-term outcomes—including brain injury detected [...] Read more.
Background: Hypoxic–ischemic encephalopathy (HIE) is a leading cause of severe neurological impairments in childhood. Therapeutic hypothermia (TH) is both safe and effective in neonates born at ≥36 weeks gestation with moderate to severe HIE. We aimed to evaluate short-term outcomes—including brain injury detected on magnetic resonance imaging (MRI)—in infants born at 34–35 weeks of gestation drawing on our clinical experience with neonates under 36 weeks of gestational age (GA). Methods: In this retrospective cohort study, 20 preterm infants with a GA of 34 to 35 weeks and a matched cohort of 80 infants with a GA of ≥36 weeks who were diagnosed with moderate to severe HIE and underwent TH were included. Infants were matched in a 1:4 ratio based on the worst base deficit in blood gas and sex. Maternal and neonatal characteristics, brain MRI findings and short term outcomes were compared. Results: Infants with a GA of 34–35 weeks had a lower birth weight and a higher rate of caesarean delivery (both p < 0.001). Apgar scores, sex, intubation rate in delivery room, blood gas pH, base deficit and lactate were comparable between the groups. Compared to infants born at ≥36 weeks of GA, preterm neonates were more likely to receive inotropes, had a longer time to achieve full enteral feeding, and experienced a longer hospital stay. The mortality rate was 10% in the 34–35 weeks GA group. Neuroimaging revealed injury in 66.7% of infants born at 34–35 weeks of gestation and in 58.8% of those born at ≥36 weeks (p = 0.56). Injury was observed across multiple brain regions, with white matter being the most frequently affected in the 34–35 weeks GA group. Thalamic and cerebellar abnormal signal intensity or diffusion restriction, punctate white matter lesions, and diffusion restriction in the corpus callosum and optic radiations were more frequently detected in infants born at 34–35 weeks of gestation. Conclusions: Our study contributes to the growing body of literature suggesting that TH may be feasible and tolerated in late preterm infants. Larger randomized controlled trials focused on this vulnerable population are necessary to establish clear guidelines regarding the safety and efficacy of TH in late preterm infants. Full article
(This article belongs to the Section Pediatric Neonatology)
17 pages, 5557 KiB  
Article
Optimal Spatial Configuration for Energy and Solar Use in Alpine-Frigid Resettlement Communities
by Bo Liu, Wei Song, Yu Liu, Chuanming Wang and Jie Song
Buildings 2025, 15(15), 2691; https://doi.org/10.3390/buildings15152691 - 30 Jul 2025
Viewed by 205
Abstract
Resettlement communities in Qinghai are located in cold, high-altitude regions with dry climates and strong solar radiation. Although not extremely cold, the moderate heating demand aligns well with high solar availability, making passive design highly effective for reducing energy use. This study investigates [...] Read more.
Resettlement communities in Qinghai are located in cold, high-altitude regions with dry climates and strong solar radiation. Although not extremely cold, the moderate heating demand aligns well with high solar availability, making passive design highly effective for reducing energy use. This study investigates solar-optimized spatial configurations that enhance passive energy performance while addressing functional settlement needs. Through parametric modeling and climate-responsive simulations, four key spatial parameters are examined: building spacing, courtyard depth, density, and volumetric ratio. The findings highlight the dominant role of front–rear spacing in solar access, with optimal values at 3–4 m for single-story and 5–10 m for two-story buildings, balancing radiation gain and land use efficiency. Courtyard depths under 2.7 m significantly limit south façade exposure due to shading from the opposite courtyard wall under low-angle winter sun. This reduction results in the south façade attaining only 55.7–79.6% of the solar radiation acquisition by an unobstructed south façade (the baseline). Meanwhile, clustered orientations reduce inter-building shading losses by 38–42% compared to dispersed layouts. A three-tiered design framework is proposed: (1) macro-scale solar orientation zoning, (2) meso-scale spacing tailored to building height, and (3) micro-scale courtyard modulation for low-angle winter radiation. Together, these strategies provide practical, scalable guidelines for energy-efficient, climate-responsive settlement design in the alpine regions of Qinghai. Full article
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16 pages, 1238 KiB  
Article
Mortality Risk of Colistin vs. Non-Colistin Use in Cancer Patients with Multidrug-Resistant Gram-Negative Bacterial Infections: Stratified by Resistance Profile and Concomitant Medications
by Soo Hyeon Lee, Yongwon Choi, Chang-Young Choi, Yeo Jin Choi and Sooyoung Shin
Medicina 2025, 61(8), 1361; https://doi.org/10.3390/medicina61081361 - 28 Jul 2025
Viewed by 350
Abstract
Background and Objectives: Cancer patients are particularly susceptible to infections caused by multidrug-resistant Gram-negative bacteria (MDR GNB) due to chemotherapy- or radiation therapy-induced immunosuppression. Colistin is often prescribed as a last-resort agent for MDR GNB infection, but its clinical benefit in oncology patients [...] Read more.
Background and Objectives: Cancer patients are particularly susceptible to infections caused by multidrug-resistant Gram-negative bacteria (MDR GNB) due to chemotherapy- or radiation therapy-induced immunosuppression. Colistin is often prescribed as a last-resort agent for MDR GNB infection, but its clinical benefit in oncology patients remains unclear. This study aims to evaluate the mortality risk associated with colistin versus non-colistin regimens in cancer patient with MDR GNB infections, stratified by resistance profiles, infection sites, and concomitant medication use. Materials and Methods: A retrospective cohort study was conducted in adult cancer patients with MDR GNB infections that are resistant to at least three antibiotic classes and identified from at least two anatomical sites at a tertiary care hospital in Korea. Propensity score-matched in a 1:3 ratio either to the colistin group or non-colistin group and multivariate Cox hazard regression analyses were used to evaluate mortality in cancer patients with MDR GNB infections, primarily Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Results: A total of 85 patients (29 patients in the colistin and 56 patients in the non-colistin group) were included in the analysis. Overall, colistin use did not show a statistically significant mortality benefit compared to non-colistin regimens (hazard ratio (HR) 0.93, 95% CI 0.47–1.87). However, the subgroup analysis revealed that colistin had a potential association with significantly lower mortality in pneumonia patients with aminoglycoside-resistant infections (HR 0.04, 95% CI 0.002–0.69). Concomitant use of antipsychotics and benzodiazepines in selected resistance profiles also correlated with improved outcomes. In contrast, a potential association was found between concomitant macrolide use and increased mortality in patients with fluoroquinolone- or penicillin-resistant profiles. Conclusions: Colistin may offer survival benefits in selected high-risk cancer patients with MDR GNB pneumonia. Treatment outcomes are influenced by resistance profiles, infection sites, and concomitant medications, indicating the significant importance of individualized antimicrobial therapy and antimicrobial stewardship in oncology patients. Full article
(This article belongs to the Section Pharmacology)
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22 pages, 6689 KiB  
Article
Design and Implementation of a Sun Outage Simulation System with High Uniformity and Stray Light Suppression Capability
by Zhen Mao, Zhaohui Li, Yong Liu, Limin Gao and Jianke Zhao
Sensors 2025, 25(15), 4655; https://doi.org/10.3390/s25154655 - 27 Jul 2025
Viewed by 354
Abstract
To enable accurate evaluation of satellite laser communication terminals under solar outage interference, this paper presents the design and implementation of a solar radiation simulation system targeting the 1540–1560 nm communication band. The system reconstructs co-propagating interference conditions through standardized and continuously tunable [...] Read more.
To enable accurate evaluation of satellite laser communication terminals under solar outage interference, this paper presents the design and implementation of a solar radiation simulation system targeting the 1540–1560 nm communication band. The system reconstructs co-propagating interference conditions through standardized and continuously tunable output, based on high irradiance and spectral uniformity. A compound beam homogenization structure—combining a multimode fiber and an apodizator—achieves 85.8% far-field uniformity over a 200 mm aperture. A power–spectrum co-optimization strategy is introduced for filter design, achieving a spectral matching degree of 78%. The system supports a tunable output from 2.5 to 130 mW with a 50× dynamic range and maintains power control accuracy within ±0.9%. To suppress internal background interference, a BRDF-based optical scattering model is established to trace primary and secondary stray light paths. Simulation results show that by maintaining the surface roughness of key mirrors below 2 nm and incorporating a U-shaped reflective light trap, stray light levels can be reduced to 5.13 × 10−12 W, ensuring stable detection of a 10−10 W signal at a 10:1 signal-to-background ratio. Experimental validation confirms that the system can faithfully reproduce solar outage conditions within a ±3° field of view, achieving consistent performance in spectrum shaping, irradiance uniformity, and background suppression. The proposed platform provides a standardized and practical testbed for ground-based anti-interference assessment of optical communication terminals. Full article
(This article belongs to the Section Communications)
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15 pages, 3786 KiB  
Article
Atomistic Mechanisms and Temperature-Dependent Criteria of Trap Mutation in Vacancy–Helium Clusters in Tungsten
by Xiang-Shan Kong, Fang-Fang Ran and Chi Song
Materials 2025, 18(15), 3518; https://doi.org/10.3390/ma18153518 - 27 Jul 2025
Viewed by 305
Abstract
Helium (He) accumulation in tungsten—widely used as a plasma-facing material in fusion reactors—can lead to clustering, trap mutation, and eventual formation of helium bubbles, critically impacting material performance. To clarify the atomic-scale mechanisms governing this process, we conducted systematic molecular statics and molecular [...] Read more.
Helium (He) accumulation in tungsten—widely used as a plasma-facing material in fusion reactors—can lead to clustering, trap mutation, and eventual formation of helium bubbles, critically impacting material performance. To clarify the atomic-scale mechanisms governing this process, we conducted systematic molecular statics and molecular dynamics simulations across a wide range of vacancy cluster sizes (n = 1–27) and temperatures (500–2000 K). We identified the onset of trap mutation through abrupt increases in tungsten atomic displacement. At 0 K, the critical helium-to-vacancy (He/V) ratio required to trigger mutation was found to scale inversely with cluster size, converging to ~5.6 for large clusters. At elevated temperatures, thermal activation lowered the mutation threshold and introduced a distinct He/V stability window. Below this window, clusters tend to dissociate; above it, trap mutation occurs with near certainty. This critical He/V ratio exhibits a linear dependence on temperature and can be described by a size- and temperature-dependent empirical relation. Our results provide a quantitative framework for predicting trap mutation behavior in tungsten, offering key input for multiscale models and informing the design of radiation-resistant materials for fusion applications. Full article
(This article belongs to the Section Materials Simulation and Design)
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18 pages, 5232 KiB  
Article
Analysis of the Characteristics of a Multi-Generation System Based on Geothermal, Solar Energy, and LNG Cold Energy
by Xinfeng Guo, Hao Li, Tianren Wang, Zizhang Wang, Tianchao Ai, Zireng Qi, Huarong Hou, Hongwei Chen and Yangfan Song
Processes 2025, 13(8), 2377; https://doi.org/10.3390/pr13082377 - 26 Jul 2025
Viewed by 285
Abstract
In order to reduce gas consumption and increase the renewable energy proportion, this paper proposes a poly-generation system that couples geothermal, solar, and liquid natural gas (LNG) cold energy to produce steam, gaseous natural gas, and low-temperature nitrogen. The high-temperature flue gas is [...] Read more.
In order to reduce gas consumption and increase the renewable energy proportion, this paper proposes a poly-generation system that couples geothermal, solar, and liquid natural gas (LNG) cold energy to produce steam, gaseous natural gas, and low-temperature nitrogen. The high-temperature flue gas is used to heat LNG; low-temperature flue gas, mainly nitrogen, can be used for cold storage cooling, enabling the staged utilization of the energy. Solar shortwave is used for power generation, and longwave is used to heat the working medium, which realizes the full spectrum utilization of solar energy. The influence of different equipment and operating parameters on the performance of a steam generation system is studied, and the multi-objective model of the multi-generation system is established and optimized. The results show that for every 100 W/m2 increase in solar radiation, the renewable energy ratio of the system increases by 1.5%. For every 10% increase in partial load rate of gas boiler, the proportion of renewable energy decreases by 1.27%. The system’s energy efficiency, cooling output, and the LNG vaporization flow rate are negatively correlated with the scale of solar energy utilization equipment. The decision variables determined by the TOPSIS (technique for order of preference by similarity to ideal solution) method have better economic performance. Its investment cost is 18.14 × 10 CNY, which is 7.83% lower than that of the LINMAP (linear programming technique for multidimensional analysis of preference). Meanwhile, the proportion of renewable energy is only 0.29% lower than that of LINMAP. Full article
(This article belongs to the Special Issue Innovations in Waste Heat Recovery in Industrial Processes)
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13 pages, 1895 KiB  
Article
Class-Dependent Solar Flare Effects on Mars’ Upper Atmosphere: MAVEN NGIMS Observations of X8.2 and M6.0 from September 2017
by Junaid Haleem and Shican Qiu
Universe 2025, 11(8), 245; https://doi.org/10.3390/universe11080245 - 25 Jul 2025
Viewed by 238
Abstract
Transient increments of X-ray radiation and extreme ultraviolet (EUV) during solar flares are strong drivers of thermospheric dynamics on Mars, yet their class-dependent impacts remain poorly measured. This work provides the first direct, side-by-side study of Martian thermospheric reactions to flares X8.2 on [...] Read more.
Transient increments of X-ray radiation and extreme ultraviolet (EUV) during solar flares are strong drivers of thermospheric dynamics on Mars, yet their class-dependent impacts remain poorly measured. This work provides the first direct, side-by-side study of Martian thermospheric reactions to flares X8.2 on 10 September 2017 and M6.0 on 17 September 2017. This study shows nonlinear, class-dependent effects, compositional changes, and recovery processes not recorded in previous investigations. Species-specific responses deviated significantly from irradiance proportionality, even though the soft X-ray flux in the X8.2 flare was 13 times greater. Argon (Ar) concentrations rose 3.28× (compared to 1.13× for M6.0), and radiative cooling led CO2 heating to approach a halt at ΔT = +40 K (X8.2) against +19 K (M6.0) at exobase altitudes (196–259 km). N2 showed the largest class difference, where temperatures rose by +126 K (X8.2) instead of +19 K (M6.0), therefore displaying flare-magnitude dependent thermal sensitivity. The 1.95× increase in O concentrations during X8.2 and the subsequent decrease following M6.0 (−39 K cooling) illustrate the contradiction between photochemical production and radiative loss. The O/CO2 ratio at 225 km dropped 46% during X8.2, revealing compositional gradients boosted by flares. Recovery timeframes varied by class; CO2 quickly re-equilibrated because of effective cooling, whereas inert species (Ar, N2) stabilized within 1–2 orbits after M6.0 but needed >10 orbits of the MAVEN satellite after the X8.2 flare. The observations of the X8.2 flare came from the western limb of the Sun, but the M6.0 flare happened on the far side. The CME shock was the primary driver of Mars’ EUV reaction. These findings provide additional information on atmospheric loss and planetary habitability by indicating that Mars’ thermosphere has a saturation threshold where strong flares induce nonlinear energy partitioning that encourages the departure of lighter species. Full article
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8 pages, 543 KiB  
Communication
Assessment of Tumor Relative Biological Effectiveness in Low-LET Proton Irradiation
by Ying-Chun Lin, Jiamin Mo and Yuan-Hao Lee
Biomedicines 2025, 13(8), 1823; https://doi.org/10.3390/biomedicines13081823 - 25 Jul 2025
Viewed by 239
Abstract
Background/Objectives: Within the range of spread-out Bragg peak (SOBP), LET (linear energy transfer) gradually increases from proton beam entrance point toward the beam exit direction. While it is expected that the change in LET would lead to correspondent change in RBE (relative [...] Read more.
Background/Objectives: Within the range of spread-out Bragg peak (SOBP), LET (linear energy transfer) gradually increases from proton beam entrance point toward the beam exit direction. While it is expected that the change in LET would lead to correspondent change in RBE (relative biological effectiveness) on many human cell lines, the incomplete cell killing due to low LET can result in tumor recurrence. Hence, this study aimed to assess the RBE on different cancer cell lines along low-LET proton SOBP. Methods: The clonogenicity of A549 and Panc-1 cells after irradiation was evaluated for investigating cell radiosensitivity in response to different types of radiation. The isoeffect doses of 6-MV photon and low-LET proton beams that resulted in equivalent cell surviving fractions at proton dose of 2 or 4 Gy were compared. Results: Ratios of α/β of A549 and Panc-1 cells from photon irradiation are 51.69 and −0.7747, respectively; RBE (2 Gy proton SOBP) on A549 and Panc-1 cells are 0.7403 ± 0.3324 and 1.0986 ± 0.3984, respectively. In addition, the change in RBE with proton LET was in a cell-specific and dose-dependent manner (LET-RBE linear correlations: A549 cells [r = 0.4673, p = 0.2430] vs. Panc-1 cells at 4 Gy [r = 0.7085, p = 0.0492]; Panc-1 cells at 2 Gy [r = −0.4123, p = 0.3100] vs. 4 Gy [r = 0.7085, p = 0.0492]). Conclusions: Compared with A549 cells, Panc-1 cells present greater resistance to low-LET proton beams. In addition, currently employed generic RBE value at 1.1 for proton therapy neglected the variation in cell-/tumor-specific radiobiological responses toward different dose levels of proton beams. Full article
(This article belongs to the Special Issue New Insights in Radiotherapy: Bridging Radiobiology and Oncology)
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26 pages, 2178 KiB  
Article
Optimizing Agri-PV System: Systematic Methodology to Assess Key Design Parameters
by Kedar Mehta and Wilfried Zörner
Energies 2025, 18(14), 3877; https://doi.org/10.3390/en18143877 - 21 Jul 2025
Viewed by 414
Abstract
Agrivoltaic (Agri-PV) systems face the critical challenge of balancing photovoltaic energy generation with crop productivity, yet systematic approaches to quantifying the trade-offs between these objectives remain scarce. In this study, we identify nine essential design indicators: panel tilt angle, elevation, photovoltaic coverage ratio, [...] Read more.
Agrivoltaic (Agri-PV) systems face the critical challenge of balancing photovoltaic energy generation with crop productivity, yet systematic approaches to quantifying the trade-offs between these objectives remain scarce. In this study, we identify nine essential design indicators: panel tilt angle, elevation, photovoltaic coverage ratio, shading factor, land equivalent ratio, photosynthetically active radiation (PAR) utilization, crop yield stability index, water use efficiency, and return on investment. We introduce a novel dual matrix Analytic Hierarchy Process (AHP) to evaluate their relative significance. An international panel of eighteen Agri-PV experts, encompassing academia, industry, and policy, provided pairwise comparisons of these indicators under two objectives: maximizing annual energy yield and sustaining crop output. The high consistency observed in expert responses allowed for the derivation of normalized weight vectors, which form the basis of two Weighted Influence Matrices. Analysis of Total Weighted Influence scores from these matrices reveal distinct priority sets: panel tilt, coverage ratio, and elevation are most influential for energy optimization, while PAR utilization, yield stability, and elevation are prioritized for crop productivity. This methodology translates qualitative expert knowledge into quantitative, actionable guidance, clearly delineating both synergies, such as the mutual benefit of increased elevation for energy and crop outcomes, and trade-offs, exemplified by the negative impact of high photovoltaic coverage on crop yield despite gains in energy output. By offering a transparent, expert-driven decision-support tool, this framework enables practitioners to customize Agri-PV system configurations according to local climatic, agronomic, and economic contexts. Ultimately, this approach advances the optimization of the food energy nexus and supports integrated sustainability outcomes in Agri-PV deployment. Full article
(This article belongs to the Section A2: Solar Energy and Photovoltaic Systems)
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18 pages, 5775 KiB  
Article
Precision Solar Spectrum Filtering in Aerogel Windows via Synergistic ITO-Ag Nanoparticle Doping for Hot-Climate Energy Efficiency
by Huilin Yang, Maoquan Huang, Mingyang Yang, Xuankai Zhang and Mu Du
Gels 2025, 11(7), 553; https://doi.org/10.3390/gels11070553 - 18 Jul 2025
Viewed by 204
Abstract
Windows are a major contributor to energy loss in buildings, particularly in hot climates where solar radiation heat gain significantly increases cooling demand. An ideal energy-efficient window must maintain high visible light transmittance while effectively blocking ultraviolet and near-infrared radiation, presenting a significant [...] Read more.
Windows are a major contributor to energy loss in buildings, particularly in hot climates where solar radiation heat gain significantly increases cooling demand. An ideal energy-efficient window must maintain high visible light transmittance while effectively blocking ultraviolet and near-infrared radiation, presenting a significant challenge for material design. We propose a plasma silica aerogel window utilizing the local surface plasmon resonance effect of plasmonic nanoparticles. This design incorporates indium tin oxide (ITO) nanospheres (for broad-band UV/NIR blocking) and silver (Ag) nanocylinders (targeted blocking of the 0.78–0.9 μm NIR band) co-doped into the silica aerogel. This design achieves a visible light transmittance of 0.8, a haze value below 0.12, and a photothermal ratio of 0.91. Building simulations indicate that compared to traditional glass, this window can achieve annual energy savings of 20–40% and significantly reduce the economic losses associated with traditional glass, providing a feasible solution for sustainable buildings. Full article
(This article belongs to the Section Gel Applications)
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