Search Results (2,211)

Accurate intraoperative differentiation between malignant and benign breast tissues, particularly the assessment of lymph node status and tumor margins, is critical for surgical decision-making and prognosis. Traditional histopathological methods, such as frozen section analysis, are time-consuming and labor-intensive. Magnetic Particle Imaging (MPI) is a novel, radiation-free modality that senses the microenvironmental properties of tissues through the dynamic response of magnetic tracers. In this study, we propose a diagnostic method utilizing the higher-order harmonic response of magnetic nanoparticles. Various ex vivo breast tissue samples were immersed in Synomag-50 nanoparticles. Using a custom-built MPI spectrometer (5 kHz excitation, 9 mT amplitude) operating in spectroscopic mode, we implemented a rapid acquisition protocol in which each sample was measured 10 times, with 0.1 s per cycle. We analyzed the magnetic response spectrum and calculated the ratio of the third to the fifth harmonic ($H_3/H_5$). Histological analysis confirmed the effective infiltration of MNPs into the interstitial spaces. The repeated measurement data demonstrated high stability. A distinct stepwise increase in harmonic ratios was observed from normal tissue to tumor-adjacent tissue and finally to malignant tumors. Specifically, malignant samples showed ratios that generally exceeded 2.2, whereas benign samples remained below 2.0. These preliminary findings suggest that the harmonic ratio could serve as a sensitive biomarker reflecting the microenvironmental constraints associated with malignancy. This study validates the feasibility of utilizing MPI signal harmonics as a quantitative metric with rapid signal acquisition capabilities for differentiating benign and malignant lymph nodes. Full article

CubeSat missions increasingly rely on microwave-band communication systems, whose antennas often exhibit directional radiation patterns. As a result, multiple antennas are commonly used to improve coverage; however, a quantitative method to evaluate their performance across all spacecraft attitudes has been lacking. This paper introduces the Coverage Ratio of CubeSat Attitude (CRCA), a metric that quantifies the proportion of orientations for which the antenna gain exceeds a required threshold. CRCA is introduced and demonstrated using the S-band command antenna system of the 6U CubeSat VERTECS. The proposed metric is then used to quantitatively compare multiple antenna placement configurations, clarifying the effect of mounting faces on attitude-dependent coverage. Electromagnetic simulations and three-dimensional radiation pattern measurements using a metal CubeSat enclosure show good agreement when splitter and cable losses are taken into account. The combined radiation pattern achieves greater than $-8.0$ dBic in 90% of attitudes in simulation, and greater than $-10.0$ dBic of attitudes in 90% in measurement. Furthermore, a CRCA-based link budget analysis demonstrates that sufficient uplink margin can be conservatively maintained under tumbling conditions. The proposed CRCA framework provides a practical and generalizable approach for evaluating antenna omnidirectionality and attitude-dependent communication performance in CubeSat missions. Full article

Boron neutron capture therapy (BNCT) is experiencing a global resurgence driven by advances in boron pharmacology, accelerator-based neutron sources, and molecular imaging-guided theranostics. BNCT produces high linear energy transfer particles with micrometer-range energy deposition, enabling cell-selective irradiation confined to boron-enriched tumor cells in a geometrically targeted region by the neutron beam. This mechanism offers the potential for exceptionally high therapeutic ratios, provided two core requirements are met: sufficient differential tumor uptake of ¹⁰B and a neutron beam with appropriate energy and penetration. After early clinical attempts in the mid-20th century were hindered by inadequate boron agents and reactor-based neutron beams, recent technological breakthroughs have made BNCT clinically viable. The development of hospital-compatible accelerator neutron sources, next-generation boron delivery systems (such as receptor-targeted compounds and nanoparticles), advanced theranostic approaches (such as ¹⁸F-BPA positron emission tomography and boron-sensitive magnetic resonance imaging), and AI-driven biodistribution modeling now support personalized treatment planning and patient selection. These innovations have catalyzed modern clinical implementation, exemplified by Japan’s regulatory approval of BNCT for recurrent head and neck cancer and the rapid expansion of clinical programs across Asia, Europe, and South America. Building on these foundations, BNCT has transitioned from a predominantly academic experimental modality into an increasingly commercialized and industrially supported therapeutic platform. The emergence of dedicated BNCT companies, international collaborations between accelerator manufacturers and hospitals, and pharmaceutical development pipelines for next-generation boron carriers has accelerated clinical translation. Moreover, BNCT now occupies a unique position among radiation modalities due to its hybrid nature, namely combining the biological targeting of radiopharmaceutical therapy with the external-beam controllability of radiotherapy, thereby offering new therapeutic opportunities where competitive approaches fall short. Emerging evidence suggests therapeutic promise in glioblastoma, recurrent head and neck cancers, melanoma, meningioma, lung cancer, sarcomas, and other difficult-to-treat malignancies. Looking ahead, continued innovation in compact neutron source engineering, boron nanocarriers, multimodal theranostics, microdosimetry-guided treatment planning, and combination strategies with systemic therapies such as immunotherapy will be essential for optimizing outcomes. Together, these converging developments position BNCT as a biologically targeted and potentially transformative modality in the era of precision oncology. Full article

In this study, ZnO thin films were prepared on the flexible stainless steel (FSS) substrates by the sol–gel method. ZnO nanorods were then hydrothermally grown in the presence of polyvinyl pyrrolidone (PVP) to obtain polymer/nanooxide composites. The microstructure and resistive switching properties of the composites were investigated. X-ray diffraction results confirmed that the PVP-doped ZnO nanorods retained the hexagonal wurtzite structure and had a preferred (002) orientation despite a slight decrease in crystallinity. Surface morphology analysis showed that the addition of PVP resulted in an increase in the nanorod density and a more regular hexagonal structure. Electrical measurements showed a significant improvement in the resistive switching behavior, with a high-resistance state to low-resistance state (HRS/LRS) ratio of 4.67 × 10³. In addition, radiation-tolerant cyclic tests demonstrated that the polymer–oxide hybrid structure effectively buffered irradiation-induced defects, stabilized conductive filament pathways, and preserved switching reliability. These results highlight the potential of PVP-doped ZnO nanorod composites as reliable, flexible, and radiation-tolerant RRAM devices for future aerospace and high-radiation electronics applications. Full article

Objectives: This study aimed to assess whether low-iodine diet (LID) adherence is associated with therapeutic response in papillary thyroid carcinoma (PTC), specifically in relation to post-therapeutic thyroglobulin (Tg) release as a surrogate marker for the acute radiation-induced response following radioactive iodine (RAI) therapy. Methods: This retrospective study included 895 patients with PTC treated with RAI. LID adherence was assessed using the urine iodine-to-creatinine (I/Cr) ratio, with <66.2 μg/g Cr defined as good adherence. The Tg ratio (ratioTg), calculated by dividing post-RAI Tg (measured 7 days after RAI) by pre-RAI Tg, was used to reflect the magnitude of the radiation-induced Tg release. Patients were stratified by ratioTg (≤1 vs. >1), and associations between LID adherence and therapeutic response were analyzed within each group. Results: Well-adherent patients exhibited significantly higher ratioTg compared to poorly adherent patients (15.7 ± 2.2 vs. 8.9 ± 1.3, p = 0.007). Among patients with ratioTg > 1 (n = 630), LID adherence was independently associated with improved therapeutic response (OR, 2.004; 95% CI, 1.270–3.162; p = 0.003). No such association was observed in patients with ratioTg ≤ 1 (n = 265; p = 0.546). Conclusions: The clinical benefit of LID appears to depend on the presence of a certain magnitude of radiation-induced Tg release. RatioTg may serve as a useful marker for identifying patients likely to benefit from LID. Full article

An analysis is presented for the steady thermophoresis and photophoresis of a homogeneous dispersion of identical aerosol spheres of typical physical properties and surface characteristics. The analysis assumes a moderately small Knudsen number (less than about 0.1), such that the gas motion lies within the slip-flow regime, including thermal creep, temperature jump, thermal stress slip, and frictional slip at the particle surfaces. Under conditions of low Peclet and Reynolds numbers, the coupled momentum and energy equations are analytically solved using a unit cell approach that explicitly incorporates interparticle interactions. Closed-form expressions are derived for the mean particle migration velocities in both thermophoresis driven by a uniform temperature gradient and photophoresis induced by an incident radiation field. The results reveal that the normalized particle velocities, referenced to those of an isolated particle, generally decrease with increasing particle volume fraction, though exceptions occur for thermophoresis. While thermal stress slip and thermal creep exert no influence on the normalized thermophoretic velocity, they markedly affect the normalized photophoretic velocity, which rises with the thermal stress slip to the thermal creep coefficient ratio. For both phenomena, the normalized migration velocities increase monotonically with the particle-to-fluid thermal conductivity ratio. Full article

Purpose: Proton beam therapy (PBT) offers superior dosimetric sparing of organs at risk compared to photon radiotherapy for non-small cell lung cancer (NSCLC); however, comparative clinical evidence regarding survival benefits remains conflicting. This systematic review and meta-analysis aimed to evaluate the clinical outcomes and toxicity profiles of PBT versus photon radiotherapy, with a specific focus on time-dependent survival patterns. Methods: We searched PubMed, EMBASE, and Cochrane CENTRAL databases for comparative studies published up to 10 October 2025. Primary outcomes were overall survival (OS), progression-free survival (PFS), and local progression-free survival (LPFS). Individual patient data (IPD) were reconstructed from Kaplan–Meier curves when hazard ratios (HRs) were not reported. Odds ratios (ORs) were calculated for survival at fixed time points (1, 3, and 5 years) and for toxicity endpoints. Results: Seven studies comprising 244,604 patients were included, encompassing retrospective cohorts, multi-institutional datasets, and one randomized trial. In the overall pooled analysis, PBT showed no statistically significant superiority over photon radiotherapy for OS (HR = 0.91, 95% CI: 0.69–1.19, p = 0.483), PFS (HR = 1.09, 95% CI: 0.81–1.47, p = 0.572), or LPFS (HR = 0.89, 95% CI: 0.47–1.69, p = 0.732). Sensitivity and subgroup analyses restricted to Stage I and Stage I–II NSCLC similarly failed to demonstrate significant differences in survival outcomes. However, exploratory time point analysis utilizing ORs revealed a distinct temporal pattern: PBT was associated with improved odds of all-cause mortality at 1 year (OR = 0.60, 95% CI: 0.49–0.73, p < 0.001). This survival advantage dissipated over time, with no significant differences observed at 3 years or 5 years. Regarding safety, PBT did not significantly reduce the odds of grade ≥ 2 radiation pneumonitis (OR = 0.98, 95% CI: 0.41–2.33, p = 0.967) or grade ≥ 3 events (OR = 1.40, p = 0.540) compared to photons. Conclusions: While long-term oncologic control appears comparable between proton and photon radiotherapy, exploratory analyses suggest that PBT is associated with improved odds of 1-year overall survival. This potential early benefit, observed in retrospective cohorts, likely reflects the mitigation of acute treatment-related mortality. These findings are hypothesis-generating and support the use of PBT for patients at high risk of toxicity and advocate for a model-based approach to patient selection. Full article

Background: Peritumoral brain edema (PTBE) is the most frequent complication for intracranial meningiomas following radiotherapy, yet no clinically validated biologically effective dose (BED) threshold capable of reliably predicting PTBE has currently been established. Although conventional radiobiological models typically assume an α/β ratio of 2–4 for benign meningiomas, whether these values accurately reflect the dose–response characteristics underlying radiation-induced PTBE remains unclear. Methods: We analyzed 67 intact meningiomas in the convexity, parasagittal, or falcine regions treated with primary linear accelerator (LINAC)-based radiotherapy. The BED values were recalculated using α/β ratios ranging from 2 to 20, and receiver operating characteristic (ROC) analyses were performed to identify the optimal BED thresholds for predicting PTBE. The most informative α/β ratio was defined as the value yielding the highest Youden’s J statistic. Results: The ROC analyses showed that an assumed α/β ratio of 14 provided the highest discriminative accuracy for predicting PTBE in the overall cohort and markedly superior performance in patients younger than 70 years (area under the curve (AUC) 0.945; Youden’s J = 0.871). The optimal BED threshold for predicting PTBE was approximately 41 Gy (α/β = 14), corresponding to ~18 Gy in a single fraction and ~5.8 Gy per fraction in a five-fraction regimen. Conclusions: The BED values calculated using α/β ratios near 14 provide the most reliable estimate of PTBE risk following primary LINAC-based radiotherapy for convexity, parasagittal, and falcine meningiomas. Maintaining prescription doses below this threshold may help reduce the likelihood of PTBE in this patient population. Full article

Growing environmental concern over plastic pollution has increased the need to address the persistence of PET-derived monomers, such as bis(2-hydroxyethyl) terephthalate (BHET) and terephthalic acid (TPA). This work examines the use of excimer radiation lamps combined with hydrogen peroxide (H₂O₂) to enhance advanced oxidation processes (AOPs) for their degradation. This approach stands out for its high selectivity, absence of mercury, and lower production of toxic byproducts. Experimental tests assessed how different operational factors affect pollutant degradation, such as the initial pollutant concentration (50–200 mg/L), the reaction volume (125–500 mL), and the H₂O₂:monomer mass ratio (0:1–6:1 for BHET and 0:1–4:1 for TPA). For BHET, the best results occurred with a 5:1 mass ratio, while TPA degraded optimally with a 3:1 ratio, with a 250 mL reaction volume and a 100 mg/L initial concentration for both compounds. Under these conditions, total degradation of the initial monomers was achieved in around 30 and 80 min for BHET and TPA, respectively, and at the end of the reaction, COD decreased by 46% and 32% relative to their initial values. In both cases, hydrogen peroxide was crucial since UV radiation alone led to much lower degradation efficiency. These results emphasize the need to optimize operational conditions for greater efficiency and establish a starting point for future use of excimer technology in the treatment of wastewater contaminated with PET and its derivatives. Additionally, the degradation data closely matched a pseudo-first-order kinetic model (R² ≈ 1), confirming its reliability for predictive analysis, which is of high importance for the simulation and optimization of the process. Full article

This paper presents a novel broadband circularly polarized optically transparent monopole antenna using indium tin oxide (ITO) and PMMA. The proposed design successfully integrates ultra-wideband circular polarization characteristics with exceptional optical transparency. The antenna, constructed with a three-layer configuration utilizing ITO films as both the radiating patch and ground plane, along with transparent PMMA serving as the substrate, features compact dimensions of 40 × 40 × 1 mm³. By leveraging a co-optimized design incorporating a slotted hexagonal-ring radiating patch, triangular perturbation ground plane, and stepped-impedance feeding structure, the antenna achieves a circularly polarized operating bandwidth of 2.8–6.6 GHz (fractional bandwidth of 77.9%), with an axial ratio < 3 dB and return loss < −15 dB. The experimental findings exhibit strong consistency with the simulations, illustrating a high level of visible-light transmittance and radiation patterns characterized by right-hand circular polarization in the positive z-axis direction (+z) and left-hand circular polarization in the negative z-axis direction (−z). This innovative antenna shows great potential for applications in smart windows, display integration, and 5G communication systems. Full article

Young adults often underuse ultraviolet radiation (UVR) protective strategies and engage in indoor tanning, heightening lifetime skin cancer risk. The national Skin Smart Campus (SSC) initiative encourages universities to adopt policies that reduce UVR exposure. We evaluated a 6-month SSC university campaign using an independent-samples pre-post design with surveys before (N = 230) and after (N = 267) implementation. The campaign included SSC designation, an educational webpage, targeted Instagram content, small media, and sunscreen dispensers. Following campaign launch, knowledge increased over time (t = 5.02, df = 493, p < 0.001), as did dispenser use (21.9% to 57.7%; χ² = 64.4, p < 0.001). The sun safety behavior composite showed an upward trend (13.5 to 14.2, t = 1.71, df = 490, p = 0.09). Variance models indicated a significant time effect (F [1, 482] = 4.55, p = 0.03, η²p = 0.01; small effect), with higher sun safety associated with greater knowledge (F = 8.29, p = 0.004, η²p = 0.02; small effect) and SSC campaign awareness (F = 56.88, p < 0.001, η²p = 0.10; large effect). In multivariable regression, campaign engagement predicted higher odds of dispenser use (Odds Ratio = 3.01, 95% CI: 1.82–4.98, p < 0.001). Implementing SSC with environmental supports and tailored education increased knowledge, sun safety, and dispenser use, highlighting the strong influence of SSC visibility and multimodal campus-wide prevention strategies. Full article

Plastic pyrolysis can not only effectively solve the environmental pollution caused by the large use of plastics products but also can produce valuable chemical products to alleviate the energy shortage problem. Firstly, this study designs a microwave pyrolysis device for polypropylene plastic based on a symmetrical circular waveguide slot radiation structure. The microwave energy is fed in through the bottom symmetrical circular waveguide port, transmitted to the slot array unit after passing through the horn amplification structure, and then uniformly radiated into the polypropylene plastic. Secondly, the finite element method is employed to conduct multi-physics field coupling calculations for the electromagnetic field, temperature field, chemical reaction field, mass transfer field of concentrated substances, and fluid field involved in the microwave pyrolysis process. Finally, to improve the efficiency of microwave pyrolysis, the wave-absorbing material SiC is introduced to investigate the effects of different doping methods and doping mass ratios m_SiC:m_PP on pyrolysis temperature distribution uniformity, pyrolysis gas yield (Y_G), energy consumption (Q), gas composition, and higher heating value (HHV). The results indicate that optimal pyrolysis performance is achieved when the microwave power is 1000 W, the pyrolysis time is 9.2 min, SiC is uniformly doped and the mass ratio is m_SiC:m_PP = 3:1. The COV of temperature is a mere 0.0004, the Y_G reaches 75.15 wt.%, and Q is 0.15 kWh, the HHV is up to 85.32 MJ/Nm³, and the percentages of C₃H₆ and CH₄ are relatively high at 72% and 11.4%. These findings confirm the designed microwave pyrolysis device can achieve uniform and high-efficiency pyrolysis capability for polypropylene plastic. Full article

Bionic airfoils are an effective method to improve aerodynamic performance and reduce the noise of wind turbine blades. To explore the impact of the lower surface of bird wing airfoils on the aerodynamic performance and noise of blades, this study combines the upper surface of the NACA0018 airfoil with the lower surfaces of the teal, long-eared owl, and sparrowhawk (CBA-T, CBA-O, CBA-S) to create three new composite bionic airfoils (CBAs). The aerodynamic performance of these airfoils is evaluated, and the CBA-O airfoil is identified as having the best aerodynamic characteristics. A comparison of the noise and vortex structures of the CBA-O, owl wing airfoil, and NACA0018 is conducted, and the mechanisms behind the CBA-O airfoil performance improvement and noise reduction are explored. The results indicate that the CBAs enhance the aerodynamic performance of the airfoils. Before stall, the aerodynamic performance of the CBA-O improves the lift-to-drag ratio by 12.7% and 119.7% compared to the owl and NACA0018 airfoils, with its average SPL significantly lower than that of the NACA0018. The CBA-O has smaller vortex sizes at the trailing-edge, and the wake vortex develops more stably, effectively reducing both surface radiation noise and wake noise. Full article

Bark is a multifunctional organ critical for tree survival, yet its functional plasticity in response to micro-environmental heterogeneity at alpine timberlines remains poorly understood. Here, we investigated the variations in bark physical traits (thickness, density), allometric scaling, and stoichiometric characteristics (C, N, P) of Abies georgei var. smithii (Viguie & Gaussen) W. C. Cheng & L. K. Fu on contrasting sunny and shady slopes in the Sygera Mountains, southeastern Tibetan Plateau. Despite the relative homogeneity of soil physicochemical properties between slope aspects, bark traits exhibited remarkable phenotypic plasticity. Trees on the shady slope possessed significantly thicker bark with higher nitrogen concentrations, adopting a “resource-acquisitive strategy”. Standardized Major Axis (SMA) regression indicated isometric scaling ($b\approx 1.03$) for trees on the shady slope, reflecting a sustained investment in bark thickness to provide thermal insulation against cold stress. Conversely, trees on the sunny slope exhibited negative allometry ($b \approx 0.87$), characterized by denser tissues and elevated C/N ratios. This shift represents a conservative strategy geared toward hydraulic safety and resistance to high radiation and evaporative loss. Crucially, our results show that bark traits are largely decoupled from soil nutrient gradients, being shaped instead by microclimate. The distinct trade-off—prioritizing insulation on shady slopes versus conservation on sunny slopes—underscores the importance of phenotypic plasticity for the persistence of timberline species in a changing climate. Full article

This paper presents a dual four-port circularly polarized (CP) MIMO antenna based on substrate integrated waveguide (SIW) technology for sub-6 GHz applications. The design consists of two identical four-port SIW-based CP-MIMO antennas arranged in a mirror-symmetric configuration with an air gap of 15 mm. Each antenna employs four symmetrically arranged cross-shaped SIW patches excited by coaxial probes. Bidirectional radiation is achieved by applying a 180° phase difference between corresponding ports of the mirror symmetric configuration, referred to as the Backward-Radiating Unit (BRU) and the Forward-Radiating Unit (FRU). The bidirectional radiation mechanism is supported by array-factor-based theoretical modelling, which explains the constructive and destructive interference under phase-controlled excitation. To ensure high isolation and stable polarization performance, the antenna design incorporates defected ground structures, inter-element decoupling strips, and vertical metallic vias. Simulations indicate an operating band from 5.1 to 5.4 GHz. Measurements show a −10 dB bandwidth from 5.25 to 5.55 GHz, with the frequency shift attributed to fabrication tolerances and measurement uncertainties. The antenna achieves inter-port isolation better than −15 dB. A 3 dB axial-ratio bandwidth is maintained across the operating band. Measured axial-ratio values remain below 3 dB from 5.25 to 5.55 GHz, while simulations predict a corresponding range from 5.1 to 5.4 GHz. The proposed configuration achieves a peak gain exceeding 4 dBi and maintains an envelope correlation coefficient below 0.05. These results confirm its suitability for CP-MIMO systems with controlled spatial coverage. With a physical size of 0.733λ₀ × 0.733λ₀ per array, the proposed antenna is well-suited for vehicular and space-constrained wireless systems requiring bidirectional CP-MIMO coverage. Full article