Search Results (666)

The investigations examined a potential reduction in discrepancies between the values of the unperturbed radiofrequency (RF) electromagnetic field (EMF) and values of the EMF measured by wearable equipment (personal exposure meters) impacted by the proximity of the human body. This was done by modelling distributed wearable (multi-location, with up to seven simultaneously locations) measurements. The performed numerical simulations mimicked distributed measurements in 24 environmental exposure scenarios (recognized as virtual measurements) covered: the horizontal or vertical propagation of the EMF and electric field vector polarization corresponding to typical conditions of far-field exposure from wireless communication systems (at a frequency of 100–3600 MHz). Physical tests using three EMF probes for simultaneous measurements have been also performed. Studies showed that the discrepancy in assessing EMF exposure by an on-body equipment and the parameters of the unperturbed EMF in the location under inspection (mimicking the contribution to measurement uncertainty from the human body proximity) may be significantly reduced by the appropriate use of a distributed measurement system. The use of averaged values, from at least three simultaneous measurements at relevant locations on the body, may reduce the uncertainty approximately threefold. Full article

In this article, we employ a Batesonian systems thinking approach to analyze politically polarized and politically polarizing encounters in the contemporary United States. We bring together Bateson’s concepts of schismogenesis, double binds, metacommunication, and transcontextualism with recent work on recognition and resonance in order to show how these encounters create moments of transcontextual double binds that produce mutual dysrecognition. We show how these moments of mutual dysrecognition become both animating forces of political polarization in the moment while also becoming constitutive poetic resonances for making sense of future events. When these moments of dysrecognition are considered alongside the removal of mechanisms that restrain schismogenesis, the United States body politic is becoming increasingly schizophrenic—split in two with both parts incommunicado with the other such that the whole system is veering towards collapse. We close by briefly considering the kind of deutero-learning, to use Bateson’s term, that might help to stave off such a collapse. Full article

Background and Objectives: Magnesium (Mg)-based materials, such as the WE43 alloy, show potential in biomedical applications owing to their advantageous mechanical properties and biodegradability; however, their quick corrosion rate and hydrogen release restrict their general clinical utilization. This study aimed to develop a novel Mg-Zn-Ca alloy system based on WE43 alloy, evaluating the influence of Zn and Ca additions on microstructure, mechanical properties, cytocompatibility, and electrochemical behavior for potential use in biodegradable orthopedic applications. Materials and Methods: The WE43-Zn-Ca alloy system was developed by alloying standard WE43 (Mg–Y–Zr–RE) with 1.5% Zn and Ca concentrations of 0.2% (WE43_0.2Ca alloy) and 0.3% (WE43_0.3Ca alloy). Microstructural analysis was performed utilizing scanning electron microscopy (SEM) in conjunction with energy-dispersive X-ray spectroscopy (EDS), while the chemical composition was validated through optical emission spectroscopy and X-ray diffraction (XRD). Mechanical properties were assessed through tribological tests. Electrochemical corrosion behavior was evaluated using potentiodynamic polarization in a 3.5% NaCl solution. Cytocompatibility was assessed in vitro on MG63 cells using cell viability assays (MTT). Results: Alloys WE43_0.2Ca and WE43_0.3Ca exhibited refined, homogeneous microstructures with grain sizes between 70 and 100 µm, without significant structural defects. Mechanical testing indicated reduced stiffness and an elastic modulus similar to human bone (19.2–20.3 GPa), lowering the risk of stress shielding. Cytocompatibility tests confirmed non-cytotoxic behavior for alloys WE43_0.2Ca and WE43_0.3Ca, with increased cell viability and unaffected cellular morphology. Conclusions: The study validates the potential of Mg-Zn-Ca alloys (especially WE43_0.3Ca) as biodegradable biomaterials for orthopedic implants due to their favorable combination of mechanical properties, corrosion resistance, and cytocompatibility. The optimization of these alloys contributed to obtaining an improved microstructure with a reduced degradation rate and a non-cytotoxic in vitro outcome, which supports efficient bone tissue regeneration and its integration into the body for complex biomedical applications. Full article

Oncological hyperthermia (HT) is a medical technique aimed at heating a specific region of the human body containing a tumour. The heat makes the tumour cells more sensitive to the cytotoxic effects of radiotherapy and chemotherapy. Electromagnetic (EM) HT devices radiate a single-frequency EM field that induces a temperature increase in the treated region of the body. The typical radiative HT frequencies are between 60 and 150 MHz for deep HT applications, while 434 MHz and 915 MHz are used for superficial HT. The input EM power can reach up to 2000 W in deep HT and 250 W in superficial applications, and the E-field should be linearly polarized. This study proposes the development and use of E-field sensors to measure the distribution and evaluate the polarization of the E-field radiated by HT devices inside equivalent phantoms. This information is fundamental for the validation and assessment of HT systems. The sensor is constituted by three mutually orthogonal probes. Each probe is composed of a dipole, a diode, and a high-impedance transmission line. The fundamental difference in the operability of this sensor with respect to the standard E-field square-law detectors lies in the high-power values of the considered EM sources. Numerical analyses were performed to optimize the design of the E-field sensor in the whole radiative HT frequency range and to characterize the sensor behaviour at the power levels of HT. Then the sensor was realized, and measurements were carried out to evaluate the E-field radiated by commercial HT systems. The results show the suitability of the developed sensor to measure the E-field radiated by HT applicators. Additionally, in the measured devices, the linear polarization is evidenced. Accordingly, the work shows that in these devices, a single probe can be used to completely characterize the field distribution. Full article

Mitochondria are currently of great interest to scientists. The role of mitochondrial DNA (mtDNA) mutations has been proven in the genesis of more than 200 pathologies, which are called mitochondrial disorders. Therefore, the study of mitochondria and mitochondrial DNA is of great interest not only for understanding cell biology but also for the treatment and prevention of many mitochondria-related pathologies. There are two main trends of mitochondrial therapy: mitochondrial replacement therapy (MRT) and mitochondrial transplantation therapy (MTT). Also, there are two main categories of MRT based on the source of mitochondria. The heterologous approach includes the following methods: pronuclear transfer technique (PNT), maternal spindle transfer (MST), Polar body genome transfer (PBT) and germinal vesicle transfer (GVT). An alternative approach is the autologous method. One promising autologous technique was the autologous germline mitochondrial energy transfer (AUGMENT), which involved isolating oogonial precursor cells from the patient, extracting their mitochondria, and then injecting them during ICSI. Transmission of defective mtDNA to the next generation can also be prevented by using these approaches. The development of a healthy child, free from genetic disorders, and the prevention of the occurrence of lethal mitochondrial disorders are the main tasks of this method. However, a number of moral, social, and cultural objections have restricted its exploration, since humanity first encountered the appearance of a three-parent baby. Therefore, this review summarizes the causes of mitochondrial diseases, the various methods involved in MRT and the results of their application. In addition, a new technology, mitochondrial transplantation therapy (MTT), is currently being actively studied. MTT is an innovative approach that involves the introduction of healthy mitochondria into damaged tissues, leading to the replacement of defective mitochondria and the restoration of their function. This technology is being actively studied in animals, but there are also reports of its use in humans. A bibliographic review in PubMed and Web of Science databases and a search for relevant clinical trials and news articles were performed. A total of 81 publications were selected for analysis. Methods of MRT procedures were reviewed, their risks described, and the results of their use presented. Results of animal studies of the MTT procedure and attempts to apply this therapy in humans were reviewed. MRT is an effective way to minimize the risk of transmission of mtDNA-related diseases, but it does not eliminate it completely. There is a need for global legal regulation of MRT. MTT is a new and promising method of treating damaged tissues by injecting the body’s own mitochondria. The considered methods are extremely good in theory, but their clinical application in humans and the success of such therapy remain a question for further study. Full article

This paper presents an enhanced circularly polarized (CP) all-textile antenna using a metasurface (MS) and slot-patterned ground (SPG) for 5.8 GHz industry, scientific, and medical (ISM)-band applications in off-body communications. The 3 × 3 MS, capable of converting the incident wave into an orthogonal direction with equal magnitude and a 90° phase difference, converts the linearly polarized (LP) wave, radiated from the fundamental radiator with a corner-truncated slot square-patch configuration, into being CP. The SPG, consisting of periodic slots with two different sizes of corner-truncated slots, redistributes the surface current on the ground plane, enhancing the axial ratio bandwidth (ARBW) of the proposed antenna. The novel combination of MS and SPG not only enables the generation and enhancement of CP characteristics but also significantly improves the impedance bandwidth (IBW), gain, and radiation efficiency by introducing additional surface wave resonances. The proposed antenna is composed of a conductive textile and a felt substrate, offering comfort and flexibility for applications where the antenna is placed in close proximity to the human body. The proposed antenna is simulated under bending in various directions, showing exceptionally similar characteristics to a flat condition. The proposed antenna is fabricated and is then verified by measurements in both free space and a human body environment. The measured IBW is 36.3%, while the ARBW is 18%. The measured gain and radiation efficiency are 6.39 dBic and 64.7%, respectively. The specific absorption rate (SAR) is simulated, and the results satisfy both US and EU safety standards. Full article

In response to the increasing politicization and polarization of discourses around gender, sexuality, and the body, feminist theorists like Judith Butler call for feminism to strive toward flexibility and responsivity. This essay lays out some of the theoretical considerations that inform studies of graphic embodiment—or studies of embodiment in graphic narratives—both generally and within feminist studies, then examines several graphic texts by Tillie Walden and Élodie Durand that exemplify feminist theories of embodiment, with particular attention to the creative co-construction of embodied narratives. Full article

Background: Diabetic lung disease, characterized by inflammation and fibrosis, is an emerging chronic complication of type 2 diabetes mellitus (T2DM). However, systematic studies on the effects of exercise interventions remain limited. This study aimed to investigate the impact of different exercise types (swimming, resistance training, and high-intensity interval training [HIIT]) on pulmonary inflammation and fibrosis in T2DM mice, and to explore underlying molecular mechanisms. Methods: A T2DM mouse model was established by a high-fat diet (HFD) combined with streptozotocin (STZ) induction. Mice were randomly divided into sedentary control, swimming, resistance training, and HIIT groups, and underwent 8 weeks of exercise intervention. After the intervention, body composition was assessed. Lung histopathological changes were evaluated by hematoxylin&eosin (HE) and Masson staining. Inflammatory cytokines, fibrosis markers, and the expression of the TGF-β1/Smad signaling pathway were detected. Macrophage infiltration and polarization were also analyzed. Results: Exercise intervention improved body composition and reduced oxidative stress in T2DM mice. All three exercise modalities downregulated inflammatory cytokine expression, inhibited macrophage activation and M1 polarization, and promoted M2 polarization. Additionally, exercise improved lung tissue structure, reduced collagen deposition, and decreased the expression of fibrosis-related markers. Furthermore, anti-fibrotic effects were mediated by suppression of the TGF-β1/Smad signaling pathway and inhibition of epithelial-mesenchymal transition (EMT). Among the interventions, HIIT demonstrated the strongest inhibitory effect on the TGF-β1/Smad pathway, while swimming showed the most significant anti-inflammatory benefits. Conclusions: Different types of exercise effectively alleviate pulmonary inflammation and fibrosis in T2DM mice. These effects are closely related to the inhibition of oxidative stress, regulation of macrophage polarization, and suppression of TGF-β1/Smad signaling activation, with swimming and HIIT demonstrating superior protective benefits. Full article

The contribution of the environment to protein folding seems obvious. The aqueous environment directs protein folding towards generating a centric hydrophobic core with a polar shell. The cell membrane environment—in which numerous proteins are anchored—to stabilise the arrangement, expects the exposure of hydrophobic residues and the concentration of polar residues in the central part—a channel for the transport of numerous molecules. The influence of these environments seems evident due to the persistent residence of proteins in their surroundings providing an external force field for structure stabilisation. Structural forms are also obtained with the participation of supporting proteins—such as proteins from the heat shock protein group—which accompany the folding process and temporarily provide an appropriate external force field in which the protein, having obtained the correct structure for its activity, is released from interaction with the supporting protein. This paper discusses an example of the contribution of Hsp104 to casein folding and the effect of disaggregase preventing inappropriate aggregation. For this purpose, a model called the fuzzy oil drop (FOD-M) was used, which takes hydrophobic interactions into account in the assessment of protein structure status. Their distribution in the protein body highlights the contribution and influence of the external force field—originating from Hsp104 and the disaggregase in this case. Full article

Macrophages are multifunctional immune cells distributed throughout the whole body, and they have functions in antigen presentation, phagocytosis, killing, and immune regulation. As the most widely studied molecule in the netrin family, netrin-1 plays a key role in neuronal navigation, angiogenesis, and cell survival. Macrophage-derived netrin-1 not only regulates neurovascular regeneration through ligand–receptor binding but also influences macrophage phenotypes by modulating polarization, thereby achieving the purpose of promoting or repairing disease damage. In this review, we will summarize the recent research advances on the role of macrophage-derived netrin-1 and its receptors in a variety of inflammatory diseases and cancers. Full article

Based on their high mechanical strength, Ti-based high-entropy alloys (HEAs) are of great potential as materials for high-performance reduced-diameter dental implants. Despite previous studies demonstrating their corrosion resistance in various simulated body fluids, their resistance in simulated buccal conditions has yet to be confirmed. In this work, the corrosion behavior of two Ti-based HEAs, TiZrHfNb, and TiZrHfNbTa was evaluated in comparison to CP-Ti and Ti-6Al-4V in artificial saliva (AS) solution and in AS with fluoride ion content (ASF). A set of electrochemical tests (electrochemical impedance spectroscopy, cyclic polarization, and Mott–Schottky) was employed and complemented with surface characterization analyses (scanning electron microscopy and atomic force microscopy) to determine dissolution and passivation mechanisms of the alloys. In general, the HEAs exhibited a far superior corrosion resistance compared to CP-Ti and Ti-6Al-4V alloys in both solutions. In the AS solution, the TiZrHfNb exhibited the highest polarization resistance and pitting potential, indicating a high corrosion resistance due to the formation of a robust passive layer. Whilst in the ASF solution, the TiZrHfNbTa showed a greater corrosion resistance due to the synergistic effect of Nb and Ta oxides that enhanced passive film stability. This finding emphasizes the role of Ta in elevating the corrosion resistance of Ti-based HEAs in the presence of fluoride ions and confirms the importance of chemical composition optimization in the development of next-generation dental alloys. Based on its electrochemical corrosion behavior, TiZrHfNbTa HEAs are promising new materials for high-performance reduced-diameter dental implants. Full article

Tumor diseases are characterized by high interindividual and intratumoral heterogeneity (ITH). The development and progression of neoplasms outline complex networks of extracellular and cellular signals that have yet to be fully elucidated. This narrative review provides a comprehensive overview of the literature related to the cellular and molecular mechanisms underlying the heterogeneity of the tumor mass. Furthermore, it examines the possible role of the tumor microenvironment in the development and support of the neoplasm, in order to highlight its potential in the construction of a diagnostic–therapeutic approach to precision medicine. Many authors underline the importance of the tumor microenvironment (TME) as it actively takes part in the growth of the neoplastic mass and in the formation of metastases and in the acquisition of resistance to anticancer drugs. In specific body districts, the ideal conditions occur for the TME establishment, particularly the inflammatory state, the recruitment of cell types, the release of specific cytokines and growth factors, hypoxic conditions. These components actively intervene by enabling tumor progression and construction of physical barriers shaped by the extracellular matrix that contribute to forming peripheral tolerance by intervention of myeloid precursors and the polarization of M2 macrophages. In recent years, ITH and the TME have assumed an important position in cancer research and pharmacology as they enable understanding the dense network of communication existing between the neoplasm and the surrounding environment, and to monitor and deepen the effects of drugs with a view to develop increasingly precise and effective therapies. In the last decade, knowledge of TME has been exploited to produce targeted molecular agents (inhibitory small molecules, monoclonal antibodies, gene therapy). Nonetheless, the bibliography shows the need to study ITH through new prognostic and predictive biomarkers (e.g., ctDNA and CTCs) and to increase its basic biology knowledge. Precision medicine is a new opportunity in the treatment of oncological diseases that is transforming the development of new drug approaches and their clinical use. Biology and biotechnologies are providing the bases for this revolution. Full article

Polarized Small-Angle Neutron Scattering is a versatile low-energy neutron scattering technique that allows for the access of magnetic information on nanosize objects of size 2–100 nm, from individual properties like the magnetization distribution inside the object to the collective behaviors, e.g., spin-glass effects or long-range magnetic ordering. The multi-scale possibilities of this technique is particularly relevant to encompass simultaneously the individual and collective many-body phenomena. In this article, we report the direct measurement of the magnetic form factor of “Prussian Blue Analog” molecular-based Ferromagnetic nanoparticles ${\mathrm{Cs}}_{\mathrm{x}}^{\mathrm{I}}{\mathrm{Ni}}^{\mathrm{II}}\left[{\mathrm{Cr}}^{\mathrm{III}}{\left(\mathrm{CN}\right)}_6\right]$ embedded in a polymer matrix with use of Polarized Small-Angle Neutron Scattering. We show that PSANS is particularly adapted to evaluate the internal magnetization distribution in nanoparticles and determine their magnetic morphology. Full article

A novel dual-band multi-linear polarization reconfigurable (MLPR) antenna for body-centric wireless communication systems (BWCS) is presented in this paper. The design comprises five symmetrically arranged multi-branch radiating units, each integrating an elliptical patch and curved spring branch for the Medical Implant Communication Service (MICS) band (403–405 MHz), and a pair of orthogonal strip patches for the Industrial, Scientific and Medical (ISM) $2.45$ GHz band (2.40–2.48 GHz). By selectively biasing PIN diodes between each unit and a central pentagonal feed, five distinct LP states with polarization directions of $0^{\circ }$, ${72}^{\circ }$, ${144}^{\circ }$, ${216}^{\circ }$, and ${288}^{\circ }$ are achieved. A dual-line isolation structure is introduced to suppress mutual coupling between radiating units, ensuring cross-polarization levels (XPLs) better than $-15.0$ dB across the operation bands. Prototypes fabricated on a $160\times 160\times 1.5$ mm³ substrate demonstrate measured $|S_{11}|<-10$ dB across 401–409 MHz and 2.34–2.53 GHz and stable omnidirectional patterns despite biasing circuitry perturbations. The compact form and robust dual-band, multi-polarization performance make the proposed antenna a promising candidate for implantable device wake-up signals and on-body data links in dense indoor environments. Full article

High-precision hyperspectral remote sensing reflectance measurement of water bodies serves as the fundamental technical basis for accurately retrieving spatiotemporal distribution characteristics of water quality parameters, providing critical data support for dynamic monitoring of aquatic ecosystems and pollution source tracing. To address the critical issue of water surface glint interference significantly affecting measurement accuracy in aquatic remote sensing, this study innovatively developed a novel sensor system based on multi-field-of-view Kohler-polarization technology. The system incorporates three Kohler illumination lenses with exceptional surface uniformity exceeding 98.2%, effectively eliminating measurement errors caused by water surface brightness inhomogeneity. By integrating three core technologies—multi-field polarization measurement, skylight blocking, and high-precision radiometric calibration—into a single spectral measurement unit, the system achieves radiation measurement accuracy better than 3%, overcoming the limitations of traditional single-method glint suppression approaches. A glint removal efficiency (GRE) calculation model was established based on a skylight-blocked approach (SBA) and dual-band power function fitting to systematically evaluate glint suppression performance. Experimental results show that the system achieves GRE values of 93.1%, 84.9%, and 78.1% at ±3°, ±7°, and ±12° field-of-view angles, respectively, demonstrating that the ±3° configuration provides a 9.2% performance improvement over the ±7° configuration. Comparative analysis with dual-band power-law fitting reveals a GRE difference of 2.1% (93.1% vs. 95.2%) at ±3° field-of-view, while maintaining excellent consistency (ΔGRE < 3.2%) and goodness-of-fit (R² > 0.96) across all configurations. Shipborne experiments verified the system’s advantages in glint suppression (9.2%~15% improvement) and data reliability. This research provides crucial technical support for developing an integrated water remote sensing reflectance monitoring system combining in situ measurements, UAV platforms, and satellite observations, significantly enhancing the accuracy and reliability of ocean color remote sensing data. Full article