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Keywords = photon production

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24 pages, 4549 KiB  
Review
Research on Tbps and Kilometer-Range Transmission of Terahertz Signals
by Jianjun Yu and Jiali Chen
Micromachines 2025, 16(7), 828; https://doi.org/10.3390/mi16070828 - 20 Jul 2025
Viewed by 358
Abstract
THz communication stands as a pivotal technology for 6G networks, designed to address the critical challenge of data demands surpassing current microwave and millimeter-wave (mmWave) capabilities. However, realizing Tbps and kilometer-range transmission confronts the “dual attenuation dilemma” comprising severe free-space path loss (FSPL) [...] Read more.
THz communication stands as a pivotal technology for 6G networks, designed to address the critical challenge of data demands surpassing current microwave and millimeter-wave (mmWave) capabilities. However, realizing Tbps and kilometer-range transmission confronts the “dual attenuation dilemma” comprising severe free-space path loss (FSPL) (>120 dB/km) and atmospheric absorption. This review comprehensively summarizes our group′s advancements in overcoming fundamental challenges of long-distance THz communication. Through systematic photonic–electronic co-optimization, we report key enabling technologies including photonically assisted THz signal generation, polarization-multiplexed multiple-input multiple-output (MIMO) systems with maximal ratio combining (MRC), high-gain antenna–lens configurations, and InP amplifier systems for complex weather resilience. Critical experimental milestones encompass record-breaking 1.0488 Tbps throughput using probabilistically shaped 64QAM (PS-64QAM) in the 330–500 GHz band; 30.2 km D-band transmission (18 Gbps with 543.6 Gbps·km capacity–distance product); a 3 km fog-penetrating link at 312 GHz; and high-sensitivity SIMO-validated 100 Gbps satellite-terrestrial communication beyond 36,000 km. These findings demonstrate THz communication′s viability for 6G networks requiring extreme-capacity backhaul and ultra-long-haul connectivity. Full article
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15 pages, 1643 KiB  
Article
Mechanical Properties of Fully Recyclable 3D-Printable Materials Used for Application in Patient-Specific Devices in Radiotherapy
by Antonio Jreije, Paulius Griškevičius, Neringa Keršienė, Jurgita Laurikaitienė, Rūta Nedzinskienė and Diana Adlienė
Polymers 2025, 17(14), 1946; https://doi.org/10.3390/polym17141946 - 16 Jul 2025
Viewed by 284
Abstract
The exponential growth of plastic production in the healthcare sector and the limited capacity of conventional recycling systems have created a global environmental challenge. Latest 3D printing technologies have the potential to solve this problem by enabling on-demand, localized manufacturing. This study aimed [...] Read more.
The exponential growth of plastic production in the healthcare sector and the limited capacity of conventional recycling systems have created a global environmental challenge. Latest 3D printing technologies have the potential to solve this problem by enabling on-demand, localized manufacturing. This study aimed to investigate the mechanical properties of 3D-printed ABS composites with Bi2O3 fillers after multiple recycling and irradiation cycles to assess their suitability for creating robust, reusable supporting devices for radiotherapy. Filaments of PLA, ABS, and ABS composites enriched with 5 wt% and 10 wt% Bi2O3 were extruded, repeatedly recycled through shredding and re-extrusion up to ten times and irradiated to 70 Gy using a 6 MeV photon beam to simulate clinical radiotherapy conditions. In contrast to PLA, ABS demonstrated better recyclability; however, after ten recycling cycles, its tensile strength declined from 25.1 MPa to 20.9 MPa, and its Young’s modulus decreased from 2503.5 MPa to 1410.4 MPa. Incorporation of 5 wt% Bi2O3 into ABS significantly improved recyclability and mechanical retention. After ten recycling rounds, an ABS composite containing 5 wt% Bi2O3 retained tensile strength of 22.2 MPa, modulus of 1553.9 MPa, and strain at break of 14.4%. In contrast, the composite enforced with 10 wt% Bi2O3 showed slightly lower performance, likely due to filler agglomeration. Under irradiation, the ABS–5 wt% Bi2O3 composite exhibited minimal additional degradation, maintaining mechanical integrity superior to other materials. These results indicate that ABS–5 wt% Bi2O3 is a promising, recyclable material for durable, patient-specific devices in radiotherapy, supporting sustainability in medical manufacturing. Full article
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38 pages, 5046 KiB  
Review
Photonics on a Budget: Low-Cost Polymer Sensors for a Smarter World
by Muhammad A. Butt
Micromachines 2025, 16(7), 813; https://doi.org/10.3390/mi16070813 - 15 Jul 2025
Viewed by 370
Abstract
Polymer-based photonic sensors are emerging as cost-effective, scalable alternatives to conventional silicon and glass photonic platforms, offering unique advantages in flexibility, functionality, and manufacturability. This review provides a comprehensive assessment of recent advances in polymer photonic sensing technologies, focusing on material systems, fabrication [...] Read more.
Polymer-based photonic sensors are emerging as cost-effective, scalable alternatives to conventional silicon and glass photonic platforms, offering unique advantages in flexibility, functionality, and manufacturability. This review provides a comprehensive assessment of recent advances in polymer photonic sensing technologies, focusing on material systems, fabrication techniques, device architectures, and application domains. Key polymer materials, including PMMA, SU-8, polyimides, COC, and PDMS, are evaluated for their optical properties, processability, and suitability for integration into sensing platforms. High-throughput fabrication methods such as nanoimprint lithography, soft lithography, roll-to-roll processing, and additive manufacturing are examined for their role in enabling large-area, low-cost device production. Various photonic structures, including planar waveguides, Bragg gratings, photonic crystal slabs, microresonators, and interferometric configurations, are discussed concerning their sensing mechanisms and performance metrics. Practical applications are highlighted in environmental monitoring, biomedical diagnostics, and structural health monitoring. Challenges such as environmental stability, integration with electronic systems, and reproducibility in mass production are critically analyzed. This review also explores future opportunities in hybrid material systems, printable photonics, and wearable sensor arrays. Collectively, these developments position polymer photonic sensors as promising platforms for widespread deployment in smart, connected sensing environments. Full article
(This article belongs to the Section A:Physics)
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12 pages, 872 KiB  
Article
Assessment of Radiation Attenuation Properties in Dental Implants Using Monte Carlo Method
by Ali Rasat, Selmi Tunc, Yigit Ali Uncu and Hasan Ozdogan
Bioengineering 2025, 12(7), 762; https://doi.org/10.3390/bioengineering12070762 - 14 Jul 2025
Viewed by 232
Abstract
This study investigated the radiation attenuation characteristics of commonly used dental implant materials across an energy spectrum relevant to dental radiology. Two titanium implants were examined, with densities of 4.428 g/cm3 and 4.51 g/cm3, respectively. The first consisted of 90.39% [...] Read more.
This study investigated the radiation attenuation characteristics of commonly used dental implant materials across an energy spectrum relevant to dental radiology. Two titanium implants were examined, with densities of 4.428 g/cm3 and 4.51 g/cm3, respectively. The first consisted of 90.39% titanium, 5.40% aluminum, and 4.21% vanadium, while the second comprised 58% titanium, 33% oxygen, 7% iron, 1% carbon, and 1% nitrogen. The third material was a zirconia implant (5Y form) composed of 94.75% zirconium dioxide, 5.00% yttrium oxide, and 0.25% aluminum oxide, exhibiting a higher density of 6.05 g/cm3. Monte Carlo simulations (MCNP6) and XCOM data were utilized to estimate photon source parameters, geometric configuration, and interactions with biological materials to calculate the half-value layer, mean free path, and tenth-value layer at varying photon energies. The results indicated that titanium alloys are well suited for low-energy imaging modalities such as CBCT and panoramic radiography due to their reduced artifact production. While zirconia implants demonstrated superior attenuation at higher energies (e.g., CT), their higher density may induce beam-hardening artifacts in low-energy systems. Future research should validate these simulation results through in vitro and clinical imaging and further explore the correlation between material-specific attenuation and CBCT image artifacts. Full article
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14 pages, 26034 KiB  
Article
High-Performance Self-Powered Broadband Photodetectors Based on a Bi2Se3 Topological Insulator/ReSe2 Heterojunction for Signal Transmission
by Yun Wei, Peng Wan, Lijian Li, Tao He, Wanyu Ma, Tong Xu, Bingwang Yang, Shulin Sha, Caixia Kan and Mingming Jiang
Photonics 2025, 12(7), 709; https://doi.org/10.3390/photonics12070709 - 14 Jul 2025
Viewed by 152
Abstract
Topological insulators (TIs) hold considerable promise for the advancement of optoelectronic technologies, including spectroscopy, imaging, and communication, owing to their remarkable optical and electrical characteristics. This study proposes a novel combination of Bi2Se3 TIs and ReSe2 [...] Read more.
Topological insulators (TIs) hold considerable promise for the advancement of optoelectronic technologies, including spectroscopy, imaging, and communication, owing to their remarkable optical and electrical characteristics. This study proposes a novel combination of Bi2Se3 TIs and ReSe2 for self-powered broadband photodetectors with high sensitivity and fast response time. The Bi2Se3/ReSe2 heterojunction photodetector achieves broadband response spectra ranging for 375 nm to 1 μm. It demonstrates a significant responsivity of 64 mA/W at a wavelength of 600 nm (1 mW/cm2), exhibits a rapid response speed of 345 μs rise/336 μs fall time, and has a 3 dB bandwidth of 1.4 kHz under zero-bias conditions. The high performance can be attributed to the suitable energy band structure of Bi2Se3/ReSe2 and high carrier mobility in surface states of Bi2Se3. Excitingly, self-powered TIs photodetectors allow for high-quality signal transmission. The TIs employed in photodetectors can stimulate the production of new optoelectronic features, but they could also be used for highly integrated photonic circuits in the future. Full article
(This article belongs to the Special Issue New Perspectives in Photodetectors)
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20 pages, 5319 KiB  
Article
Multiscale 2PP and LCD 3D Printing for High-Resolution Membrane-Integrated Microfluidic Chips
by Julia K. Hoskins, Patrick M. Pysz, Julie A. Stenken and Min Zou
Nanomanufacturing 2025, 5(3), 11; https://doi.org/10.3390/nanomanufacturing5030011 - 12 Jul 2025
Viewed by 218
Abstract
This study presents a microfluidic chip platform designed using a multiscale 3D printing strategy for fabricating microfluidic chips with integrated, high-resolution, and customizable membrane structures. By combining two-photon polymerization (2PP) for submicron membrane fabrication with liquid crystal display printing for rapid production of [...] Read more.
This study presents a microfluidic chip platform designed using a multiscale 3D printing strategy for fabricating microfluidic chips with integrated, high-resolution, and customizable membrane structures. By combining two-photon polymerization (2PP) for submicron membrane fabrication with liquid crystal display printing for rapid production of larger components, this approach addresses key challenges in membrane integration, including sealing reliability and the use of transparent materials. Compared to fully 2PP-based fabrication, the multiscale method achieved a 56-fold reduction in production time, reducing total fabrication time to approximately 7.2 h per chip and offering a highly efficient solution for integrating complex structures into fluidic chips. The fabricated chips demonstrated excellent mechanical integrity. Burst pressure testing showed that all samples withstood internal pressures averaging 1.27 ± 0.099 MPa, with some reaching up to 1.4 MPa. Flow testing from ~35 μL/min to ~345 μL/min confirmed stable operation in 75 μm square channels, with no leakage and minimal flow resistance up to ~175 μL/min without deviation from the predicted behavior in the 75 μm. Membrane-integrated chips exhibited outlet flow asymmetries greater than 10%, indicating active fluid transfer across the membrane and highlighting flow-dependent permeability. Overall, this multiscale 3D printing approach offers a scalable and versatile solution for microfluidic device manufacturing. The method’s ability to integrate precise membrane structures enable advanced functionalities such as diffusion-driven particle sorting and molecular filtration, supporting a wide range of biomedical, environmental, and industrial lab-on-a-chip applications. Full article
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16 pages, 3084 KiB  
Article
Generating Large Time–Bandwidth Product RF-Chirped Waveforms Using Vernier Dual-Optical Frequency Combs
by Mohammed S. Alshaykh
Photonics 2025, 12(7), 700; https://doi.org/10.3390/photonics12070700 - 11 Jul 2025
Viewed by 203
Abstract
Chirped radio-frequency signals are essential waveforms in radar systems. To enhance resolution and improve the signal-to-noise ratio through higher energy transmission, chirps with high time–bandwidth products are highly desirable. Photonic technologies, with their ability to handle broad electrical bandwidths, have been widely employed [...] Read more.
Chirped radio-frequency signals are essential waveforms in radar systems. To enhance resolution and improve the signal-to-noise ratio through higher energy transmission, chirps with high time–bandwidth products are highly desirable. Photonic technologies, with their ability to handle broad electrical bandwidths, have been widely employed in the generation, filtering, processing, and detection of broadband electrical waveforms. In this work, we propose a photonics-based large-TBWP RF chirp generator utilizing dual optical frequency combs with a small difference in the repetition rate. By employing dispersion modules for frequency-to-time mapping, we convert the spectral interferometric patterns into a temporal RF sinusoidal carrier signal whose frequency is swept through the optical shot-to-shot delay. We derive analytical expressions to quantify the system’s performance under various design parameters, including the comb repetition rate and its offset, the second-order dispersion, the transform-limited optical pulse width, and the photodetector’s bandwidth limitations. We benchmark the expected system performance in terms of RF bandwidth, chirp duration, chirp rate, frequency step size, and TBWP. Using realistic dual-comb source parameters, we demonstrate the feasibility of generating RF chirps with a duration of 284.44 μs and a bandwidth of 234.05 GHz, corresponding to a TBWP of 3.3×107. Full article
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22 pages, 2719 KiB  
Article
Itararé Group Sandstone as a Sustainable Alternative Material for Photon Radiation Shielding
by Gabrielli W. Pietralla, Isonel S. Meneguzzo and Luiz F. Pires
Appl. Sci. 2025, 15(13), 7559; https://doi.org/10.3390/app15137559 - 5 Jul 2025
Viewed by 276
Abstract
The materials typically used for radiation shielding include lead, concrete, and polymers. However, some of these materials can be toxic or very expensive to produce. This raises interest in using more readily available natural materials, such as rocks, as an alternative. In this [...] Read more.
The materials typically used for radiation shielding include lead, concrete, and polymers. However, some of these materials can be toxic or very expensive to produce. This raises interest in using more readily available natural materials, such as rocks, as an alternative. In this study, we analyzed the radiation shielding efficiency of sandstones. We evaluated different layers of rock and obtained shielding parameters based on the composition of various oxides. The analysis revealed that these layers showed a predominance of silicon and aluminum oxides. Notably, the lowest photon energies (0.015 MeV and 0.1 MeV) displayed significant differences in photon attenuation, as indicated by linear and mass attenuation coefficients. This suggests that the chemical composition of the samples had a considerable impact on their shielding performance. Samples containing higher amounts of heavier elements proved to be more effective at attenuating radiation, efficiently reducing 50% (half-value layer) and 90% (tenth-value layer) of the photons. Additionally, the presence of these heavier elements decreased the production of secondary photons (buildup factor), further enhancing the samples’ efficiency in shielding against radiation. Our results indicate that sandstones hold potential for radiation shielding, particularly when they contain higher quantities of heavier elements. Full article
(This article belongs to the Special Issue Electromagnetic Radiation and Human Environment)
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15 pages, 1019 KiB  
Article
Genotypic Variability in Growth and Leaf-Level Physiological Performance of Highly Improved Genotypes of Pinus radiata D. Don Across Different Sites in Central Chile
by Sergio Espinoza, Marco Yáñez, Carlos Magni, Eduardo Martínez-Herrera, Karen Peña-Rojas, Sergio Donoso, Marcos Carrasco-Benavides and Samuel Ortega-Farias
Forests 2025, 16(7), 1108; https://doi.org/10.3390/f16071108 - 4 Jul 2025
Viewed by 211
Abstract
Pinus radiata D. Don is planted in South Central Chile on a wide range of sites using genetically improved genotypes for timber production. As drought events are expected to increase with ongoing climatic change, the variability in gas exchange, which could impact growth [...] Read more.
Pinus radiata D. Don is planted in South Central Chile on a wide range of sites using genetically improved genotypes for timber production. As drought events are expected to increase with ongoing climatic change, the variability in gas exchange, which could impact growth and water use, needs to be evaluated. In this study, we assessed the genotypic variability of leaf-level light-saturated photosynthesis (Asat), stomatal conductance (gs), transpiration (E), intrinsic water use efficiency (iWUE), and Chlorophyll a fluorescence (OJIP-test parameters) among 30 P. radiata genotypes (i.e., full-sib families) from third-cycle parents at age 6 years on three sites in Central Chile. We also evaluated tree height (HT), diameter at breast height (DBH), and stem index volume (VOL). Families were ranked for HT as top-15 and bottom-15. In the OJIP-test parameters we observed differences at the family level for the maximum quantum yield of primary PSII photochemistry (Fv/Fm), the probability that a photon trapped by the PSII reaction center enters the electron transport chain (ψEo), and the potential for energy conservation from photons captured by PSII to the reduction in intersystem electron acceptors (PIABS). Fv/Fm, PIABS, and ψEo ranged from 0.82 to 0.87, 45 to 95, and 0.57 to 0.64, respectively. Differences among families for growth and not for leaf-level physiology were detected. DBT, H, and VOL were higher in the top-15 families (12.6 cm, 8.4 m, and 0.10 m3, respectively) whereas Asat, gs, E, and iWUE were similar in both the top-15 and bottom-15 families (4.0 μmol m−2 s−1, 0.023 mol m−2 s−1, 0.36 mmol m−2 s−1, and 185 μmol mol m−2 s−1, respectively). However, no family by site interaction was detected for growth and leaf-level physiology. The results of this study suggest that highly improved genotypes of P. radiata have uniformity in leaf-level physiological rates, which could imply uniform water use at the stand-level. The family variation found in PIABS suggests that this parameter could be incorporated to select genotypes tolerant to environmentally stressful conditions. Full article
(This article belongs to the Special Issue Water Use Efficiency of Forest Trees)
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23 pages, 2820 KiB  
Article
Optimized Spectral and Spatial Design of High-Uniformity and Energy-Efficient LED Lighting for Italian Lettuce Cultivation in Miniature Plant Factories
by Zihan Wang, Haitong Huang, Mingming Shi, Yuheng Xiong, Jiang Wang, Yilin Wang and Jun Zou
Horticulturae 2025, 11(7), 779; https://doi.org/10.3390/horticulturae11070779 - 3 Jul 2025
Viewed by 323
Abstract
Optimizing artificial lighting in controlled-environment agriculture is crucial for enhancing crop productivity and resource efficiency. This study presents a spectral–spatial co-optimization strategy for LED lighting tailored to the physiological needs of Italian lettuce (Lactuca sativa L. var. italica). A miniature plant factory [...] Read more.
Optimizing artificial lighting in controlled-environment agriculture is crucial for enhancing crop productivity and resource efficiency. This study presents a spectral–spatial co-optimization strategy for LED lighting tailored to the physiological needs of Italian lettuce (Lactuca sativa L. var. italica). A miniature plant factory system was developed with dimensions of 400 mm × 400 mm × 500 mm (L × W × H). Seven customized spectral treatments were created using 2835-packaged LEDs, incorporating various combinations of blue and violet LED chips with precisely controlled concentrations of red phosphor. The spectral configurations were aligned with the measured absorption peaks of Italian lettuce (450–470 nm and 640–670 nm), achieving a spectral mixing uniformity exceeding 99%, while the spatial light intensity uniformity surpassed 90%. To address spatial light heterogeneity, a particle swarm optimization (PSO) algorithm was employed to determine the optimal LED arrangement, which increased the photosynthetic photon flux density (PPFD) uniformity from 83% to 93%. The system operates with a fixture-level power consumption of only 75 W. Experimental evaluations across seven treatment groups demonstrated that the E-spectrum group—comprising two violet chips, one blue chip, and 0.21 g of red phosphor—achieved the highest agronomic performance. Compared to the A-spectrum group (three blue chips and 0.19 g of red phosphor), the E-spectrum group resulted in a 25% increase in fresh weight (90.0 g vs. 72.0 g), a 30% reduction in SPAD value (indicative of improved light-use efficiency), and compared with Group A, Group E exhibited significant improvements in plant morphological parameters, including a 7.05% increase in plant height (15.63 cm vs. 14.60 cm), a 25.64% increase in leaf width (6.37 cm vs. 5.07 cm), and a 6.35% increase in leaf length (10.22 cm vs. 9.61 cm). Furthermore, energy consumption was reduced from 9.2 kWh (Group A) to 7.3 kWh (Group E). These results demonstrate that integrating spectral customization with algorithmically optimized spatial distribution is an effective and scalable approach for enhancing both crop yield and energy efficiency in vertical farming systems. Full article
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16 pages, 5292 KiB  
Article
A Large-Bandwidth Electro-Optic Modulator with U-T Double-Layer Traveling-Wave Electrode Structure Based on Thin-Film Lithium Niobate
by Yuxiang Hao, Haiou Li, Yue Li, Haisheng Li, Yingbo Liu, Jiayu Yang and Liangpeng Qin
Photonics 2025, 12(7), 648; https://doi.org/10.3390/photonics12070648 - 26 Jun 2025
Viewed by 369
Abstract
Thin-film lithium niobate (TFLN) electro-optic modulators serve as critical components in microwave photonic systems. To improve device performance, we developed a U-T double-layer traveling-wave electrode configuration. Using finite element analysis, we systematically simulated and optimized both modulation efficiency and radiofrequency characteristics, ultimately realizing [...] Read more.
Thin-film lithium niobate (TFLN) electro-optic modulators serve as critical components in microwave photonic systems. To improve device performance, we developed a U-T double-layer traveling-wave electrode configuration. Using finite element analysis, we systematically simulated and optimized both modulation efficiency and radiofrequency characteristics, ultimately realizing a low half-wave voltage-length product of 1.77 V·cm, a minimal optical loss of 0.022 dB/cm, and an ultra-wide modulation bandwidth surpassing 100 GHz. Full article
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21 pages, 4150 KiB  
Article
Novel Cerium- and Terbium-Doped Gadolinium Fluoride Nanoparticles as Radiosensitizers with Pronounced Radiocatalytic Activity
by Nikita A. Pivovarov, Danil D. Kolmanovich, Nikita N. Chukavin, Irina V. Savintseva, Nelli R. Popova, Alexander E. Shemyakov, Arina D. Filippova, Maria A. Teplonogova, Alexandra V. Yurkovskaya, Ivan. V. Zhukov, Azamat Y. Akkizov and Anton L. Popov
Biomedicines 2025, 13(7), 1537; https://doi.org/10.3390/biomedicines13071537 - 24 Jun 2025
Viewed by 477
Abstract
Background: The use of nanoradiosensitizers is a promising strategy for the precision enhancement of tumor tissue damage during radiotherapy. Methods: Here, we propose a novel biocompatible theranostic agent based on gadolinium fluoride doped with cerium and terbium (Gd0.7Ce0.2Tb0.1 [...] Read more.
Background: The use of nanoradiosensitizers is a promising strategy for the precision enhancement of tumor tissue damage during radiotherapy. Methods: Here, we propose a novel biocompatible theranostic agent based on gadolinium fluoride doped with cerium and terbium (Gd0.7Ce0.2Tb0.1F3 NPs), which showed pronounced radiocatalytic activity when exposed to photon or proton beam irradiation, as well as remarkable MRI contrast ability. A scheme for the production of biocompatible colloidally stable Gd0.7Ce0.2Tb0.1F3 NPs was developed. Comprehensive physicochemical characterization of these NPs was carried out, including TEM, SEM, XRD, DLS, and EDX analyses, as well as UV–vis spectroscopy and MRI relaxation assays. Results: Cytotoxicity analysis of Gd0.7Ce0.2Tb0.1F3 NPs in vitro and in vivo revealed a high level of biocompatibility. It was shown that Gd0.7Ce0.2Tb0.1F3 NPs effectively accumulate in MCF-7 tumor cells. A study of their radiosensitizing activity demonstrated that the combined effect of Gd0.7Ce0.2Tb0.1F3 NPs and X-ray irradiation leads to a dose-dependent decrease in mitochondrial membrane potential, a sharp increase in the level of intracellular ROS, and the subsequent development of radiation-induced apoptosis. Conclusions: This outstanding radiosensitizing effect is explained by the radiocatalytic generation of reactive oxygen species by the nanoparticles, which goes beyond direct physical dose enhancement. It emphasizes the importance of evaluating the molecular mechanisms underlying the sensitizing effectiveness of potential nanoradiosensitizers before choosing conditions for their testing in in vivo models. Full article
(This article belongs to the Special Issue Latest Advancements in Radiotherapy)
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13 pages, 1321 KiB  
Article
Nonlinear Responses and Population-Level Coupling of Growth and MC-LR Production in Microcystis aeruginosa Under Multifactorial Conditions
by Melina Celeste Crettaz-Minaglia, Sandro Goñi and Leda Giannuzzi
Phycology 2025, 5(2), 26; https://doi.org/10.3390/phycology5020026 - 18 Jun 2025
Viewed by 323
Abstract
Microcystis aeruginosa is a cyanobacterium frequently associated with toxic blooms in eutrophic freshwater systems. Certain strains produce microcystins (MCs), a group of hepatotoxins with significant ecological and public health implications. In this study, we examined the quantitative response of a temperate native M. [...] Read more.
Microcystis aeruginosa is a cyanobacterium frequently associated with toxic blooms in eutrophic freshwater systems. Certain strains produce microcystins (MCs), a group of hepatotoxins with significant ecological and public health implications. In this study, we examined the quantitative response of a temperate native M. aeruginosa strain to combinations of temperature (26, 30, and 36 °C), light intensity (30, 50, and 70 µmol photons·m−2·s−1), and N:P ratio (10, 100, 150), using a full-factorial experimental design. Growth parameters (µ, lag phase duration, and maximum cell density), chlorophyll-a production, and MC-LR synthesis were modeled using Gompertz, linear, and dynamic approaches. High temperature and irradiance increased the specific growth rate but decreased final biomass, while elevated N:P ratios shortened the lag phase. MC-LR production peaked under low temperature, low irradiance, and low N:P ratio. Although MC-LR synthesis did not correlate positively with growth rate, and the environmental conditions maximizing growth differed from those enhancing toxin production, a population-level coupling between both processes was observed using the Long model. These findings suggest that MC-LR synthesis in M. aeruginosa is not merely a metabolic by-product of growth, but a context-dependent trait with potential adaptive significance. Full article
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27 pages, 1540 KiB  
Review
Cyanobacterial UV Pigments Evolved to Optimize Photon Dissipation Rather than Photoprotection
by Aleksandar Simeonov and Karo Michaelian
Biophysica 2025, 5(2), 23; https://doi.org/10.3390/biophysica5020023 - 18 Jun 2025
Viewed by 497
Abstract
An ancient repertoire of ultraviolet (UV)-absorbing pigments which survive today in the phylogenetically oldest extant photosynthetic organisms, the cyanobacteria, point to a direction in evolutionary adaptation of the pigments and their associated biota; from largely UV-C absorbing pigments in the Archean to pigments [...] Read more.
An ancient repertoire of ultraviolet (UV)-absorbing pigments which survive today in the phylogenetically oldest extant photosynthetic organisms, the cyanobacteria, point to a direction in evolutionary adaptation of the pigments and their associated biota; from largely UV-C absorbing pigments in the Archean to pigments covering ever more of the longer wavelength UV and visible regions in the Phanerozoic. Since photoprotection is not dependent on absorption, such a scenario could imply selection of photon dissipation rather than photoprotection over the evolutionary history of life, consistent with the thermodynamic dissipation theory of the origin and evolution of life which suggests that the most important hallmark of biological evolution has been the covering of Earth’s surface with organic pigment molecules and water to absorb and dissipate ever more completely the prevailing surface solar spectrum. In this article we compare a set of photophysical, photochemical, biosynthetic, and other inherent properties of the two dominant classes of cyanobacterial UV-absorbing pigments, the mycosporine-like amino acids (MAAs) and scytonemins. We show that the many anomalies and paradoxes related to these biological pigments, for example, their exudation into the environment, spectral coverage of the entire high-energy part of surface solar spectrum, their little or null photoprotective effect, their origination at UV-C wavelengths and then spreading to cover the prevailing Earth surface solar spectrum, can be better understood once photodissipation, and not photosynthesis or photoprotection, is considered as being the important variable optimized by nature. Full article
(This article belongs to the Special Issue Molecular Structure and Simulation in Biological System 3.0)
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21 pages, 7182 KiB  
Article
Nanovesicles and Human Skin Interaction: A Comparative Ex-Vivo Study
by Elisabetta Esposito, Valentyn Dzyhovski, Federico Santamaria, Catia Contado, Cinzia Brenna, Luca Maria Neri, Paola Secchiero, Francesco Spinozzi, Alessia Pepe, Michał Rawski, Maria Grazia Ortore, Paolo Mariani, Andrea Galvan, Laura Calderan and Manuela Malatesta
Nanomaterials 2025, 15(12), 937; https://doi.org/10.3390/nano15120937 - 16 Jun 2025
Viewed by 364
Abstract
The topical administration of drugs on the skin by nanovesicular systems can represent a tool to treat skin pathologies. The study of nanovesicle biodistribution after skin administration is crucial to understanding their transdermal potential. A formative study enabled us to investigate the influence [...] Read more.
The topical administration of drugs on the skin by nanovesicular systems can represent a tool to treat skin pathologies. The study of nanovesicle biodistribution after skin administration is crucial to understanding their transdermal potential. A formative study enabled us to investigate the influence of some methods in the production of nanovesicles based on phosphatidylcholine, differing in their ethanol amount. Particularly, both liposomes and ethosomes produced by different methods, i.e., microfluidics and solvent injection, were considered. The evaluation of size distribution, shape and internal morphology was performed using photon correlation spectroscopy, cryogenic electron microscopy, hyperspectral dark-field microscopy and small-angle X-ray scattering. Transmission electron microscopy was then used to observe and compare the transdermal passage of selected liposomes and ethosomes applied to human skin explants in a bioreactor. The mean diameters of nanovesicles prepared by the ethanol injection method were smaller with respect to those obtained by microfluidics, measuring roughly 140 and 230 nm, respectively. The uni- or multilamellar ultrastructure of the vesicles was influenced by the solvent injection procedure. Ultrastructural analysis of skin penetration revealed (i) the ability of intact vesicles to cross the different skin layers, with ethosomes produced by the water injection method showing greater transdermal potential and (ii) the role of ethanol as a penetration enhancer. Full article
(This article belongs to the Special Issue Green Nanoparticles for Topical Administration of Drugs)
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