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Biomedicines
Special Issues
Latest Advancements in Radiotherapy
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Latest Advancements in Radiotherapy

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 562

Special Issue Editor

Dr. Moshi Geso

E-Mail Website
Guest Editor
Discipline of Medical Radiations, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, Australia
Interests: nanoparticles; radiation; radiotherapy; radiology; dose; radio-sensitization; ionizing radiations; theranostic; radiobiology; non-ionizing radiation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Radiotherapy is normally a treatment method for more than 60% of cancer patients, alongside either surgery or chemotherapy or in combination. This common cancer treatment procedure is based on technological and radiobiological advancements.

This Special Issue will comprise research outputs of both the latest technological developments and/or physics-based studies of radiotherapy, such as dosimetry. Additionally, it will include research studies based on radiobiological advancements.

Another aspect of this Special Issue will be its inclusion of studies employing nanotechnology to improve the quality and efficiency of radiotherapy. This could involve the application of nanoparticles to enhance radiotherapy doses delivered to tumors. Moreover, this Special Issue will also accept research works investigating the latest radiotherapy advancements, such as FLASH beams and studies investigating various beams employed in radiotherapy.

Dr. Moshi Geso
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • radiobiology
  • dosimetry
  • nanoparticles
  • FLASH
  • radiation

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

21 pages, 4150 KiB  
Article
Novel Cerium- and Terbium-Doped Gadolinium Fluoride Nanoparticles as Radiosensitizers with Pronounced Radiocatalytic Activity
by Nikita A. Pivovarov, Danil D. Kolmanovich, Nikita N. Chukavin, Irina V. Savintseva, Nelli R. Popova, Alexander E. Shemyakov, Arina D. Filippova, Maria A. Teplonogova, Alexandra V. Yurkovskaya, Ivan. V. Zhukov, Azamat Y. Akkizov and Anton L. Popov
Biomedicines 2025, 13(7), 1537; https://doi.org/10.3390/biomedicines13071537 - 24 Jun 2025
Viewed by 449
Abstract
Background: The use of nanoradiosensitizers is a promising strategy for the precision enhancement of tumor tissue damage during radiotherapy. Methods: Here, we propose a novel biocompatible theranostic agent based on gadolinium fluoride doped with cerium and terbium (Gd0.7Ce0.2Tb0.1 [...] Read more.
Background: The use of nanoradiosensitizers is a promising strategy for the precision enhancement of tumor tissue damage during radiotherapy. Methods: Here, we propose a novel biocompatible theranostic agent based on gadolinium fluoride doped with cerium and terbium (Gd0.7Ce0.2Tb0.1F3 NPs), which showed pronounced radiocatalytic activity when exposed to photon or proton beam irradiation, as well as remarkable MRI contrast ability. A scheme for the production of biocompatible colloidally stable Gd0.7Ce0.2Tb0.1F3 NPs was developed. Comprehensive physicochemical characterization of these NPs was carried out, including TEM, SEM, XRD, DLS, and EDX analyses, as well as UV–vis spectroscopy and MRI relaxation assays. Results: Cytotoxicity analysis of Gd0.7Ce0.2Tb0.1F3 NPs in vitro and in vivo revealed a high level of biocompatibility. It was shown that Gd0.7Ce0.2Tb0.1F3 NPs effectively accumulate in MCF-7 tumor cells. A study of their radiosensitizing activity demonstrated that the combined effect of Gd0.7Ce0.2Tb0.1F3 NPs and X-ray irradiation leads to a dose-dependent decrease in mitochondrial membrane potential, a sharp increase in the level of intracellular ROS, and the subsequent development of radiation-induced apoptosis. Conclusions: This outstanding radiosensitizing effect is explained by the radiocatalytic generation of reactive oxygen species by the nanoparticles, which goes beyond direct physical dose enhancement. It emphasizes the importance of evaluating the molecular mechanisms underlying the sensitizing effectiveness of potential nanoradiosensitizers before choosing conditions for their testing in in vivo models. Full article
(This article belongs to the Special Issue Latest Advancements in Radiotherapy)
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