5 Results Found

Advanced Search

Select all

Results per page

Select all

Article

13 Citations

4,990 Views

19 Pages

The Abuse Potential of Novel Synthetic Phencyclidine Derivative 1-(1-(4-Fluorophenyl)Cyclohexyl)Piperidine (4′-F-PCP) in Rodents

In Soo Ryu,
Oc-Hee Kim,
Young Eun Lee,
Ji Sun Kim,
Zhan-Hui Li,
Tae Wan Kim,
Ri-Na Lim,
Young Ju Lee,
Jae Hoon Cheong and
Eun Young Jang
+ 5 authors

Int. J. Mol. Sci.2020, 21(13), 4631;https://doi.org/10.3390/ijms21134631

29 June 2020

The dissociative anesthetic phencyclidine (PCP) and PCP derivatives, including 4′-F-PCP, are illegally sold and abused worldwide for recreational and non-medical uses. The psychopharmacological properties and abuse potential of 4′-F-PCP h...

Full Article

Article

1,157 Views

37 Pages

Synthesis and Structure-Affinity Relationships of Receptor Ligands with 1,3-Dioxane Structure

Elisabeth Quick,
Dirk Schepmann and
Bernhard Wünsch

Pharmaceuticals2025, 18(9), 1300;https://doi.org/10.3390/ph18091300

29 August 2025

Background/Objectives: Ligands blocking σ₁ receptors or NMDA receptors show promising pharmacological properties, such as analgesia or neuroprotection. It had been shown that depending on the stereochemistry and substitution pattern, 1,3-dioxna...

Full Article

Review

1 Citations

4,805 Views

40 Pages

The Blurred Lines Between New Psychoactive Substances and Potential Chemical Weapons

Loreto N. Valenzuela-Tapia,
Cristóbal A. Quintul,
Nataly D. Rubio-Concha,
Luis Toledo-Ríos,
Catalina Salas-Kuscevic,
Andrea V. Leisewitz,
Pamela Cámpora-Oñate and
Javier Campanini-Salinas

Toxics2025, 13(8), 659;https://doi.org/10.3390/toxics13080659

1 August 2025

The historical use of toxic chemicals to cause intentional harm has evolved from blister agents in World War I to highly lethal organophosphates and emerging families of chemicals, such as Novichok. In turn, medical or recreational substances like fe...

Full Article

Review

2 Citations

9,174 Views

29 Pages

Methods for GC/MS Analysis of the Most Commonly Seized Drugs of Abuse and Their Metabolites in Biological Samples

Ivan Kojić,
Violeta M. Đurović,
Yulia A. Smyatskaya,
Nemanja Brkljača,
Angi E. Skhvediani,
Andrey V. Vasin,
Ksenija Stojanović and
Saša D. Đurović

Chemosensors2025, 13(8), 286;https://doi.org/10.3390/chemosensors13080286

4 August 2025

Gas chromatography with mass spectrometry (GC-MS) is a common analytical technique used for identifying and quantifying drugs of abuse, as well as their metabolites, extracted from biological samples. Depending on the properties of the analyzed compo...

Full Article

Article

5 Citations

8,557 Views

10 Pages

Toxicity Studies on Novel N-Substituted Bicyclo-Heptan-2-Amines at NMDA Receptors

Natalia Coleman,
Zeynep Ates-Alagoz,
Boyenoh Gaye,
Michelle Farbaniec,
Shengguo Sun and
Adeboye Adejare

Pharmaceuticals2013, 6(4), 536-545;https://doi.org/10.3390/ph6040536

12 April 2013

Several novel norcamphor derivatives were designed and synthesized as uncompetitive NMDA receptor antagonists at the phencyclidine (PCP) binding site. Such compounds have potential as ligands for understanding and possibly the treatment of several n...

Full Article